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Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease.
Clin Neurol Neurosurg 2013; 115(9):1693-6CN

Abstract

BACKGROUND

Genetic risk factors play an important role in the pathogenesis of Alzheimer's disease (AD). In this case-control study, we examined the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and their correlation with this pathology.

OBJECTIVE

To verify the association between MTHFR C677T and A1298C polymorphisms and Alzheimer's disease.

METHOD

This work was conducted as a case-control study. Cases consisted of thirty-eight patients and 100 individuals without dementia constituted the control group. Genotyping of MTHFR polymorphisms was performed on patients and controls.

RESULT

Genetic analyses did not indicate a significant association between the MTHFR C677T mutation and AD (C/T: 63.15% versus 39%, p=0.087). However, the genotype prevalence of the missense variant MTHFR A1298C was significantly different between patients and controls (A/C: 55% versus 7%, p<10(-3)). Our data suggest an association between the MTHFR A1298C mutation and AD; however, the MTHFR C677T mutation did not contribute to susceptibility for AD.

CONCLUSION

The MTHFR A1298C polymorphism is a possible risk factor for Alzheimer's disease.

Authors+Show Affiliations

Laboratory of Molecular Biology, Department of Hematology, Military Hospital, Tunis, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23659764

Citation

Mansouri, Leila, et al. "Association of Methylenetetrahydrofolate Reductase Polymorphisms With Susceptibility to Alzheimer's Disease." Clinical Neurology and Neurosurgery, vol. 115, no. 9, 2013, pp. 1693-6.
Mansouri L, Fekih-Mrissa N, Klai S, et al. Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease. Clin Neurol Neurosurg. 2013;115(9):1693-6.
Mansouri, L., Fekih-Mrissa, N., Klai, S., Mansour, M., Gritli, N., & Mrissa, R. (2013). Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease. Clinical Neurology and Neurosurgery, 115(9), pp. 1693-6. doi:10.1016/j.clineuro.2013.03.015.
Mansouri L, et al. Association of Methylenetetrahydrofolate Reductase Polymorphisms With Susceptibility to Alzheimer's Disease. Clin Neurol Neurosurg. 2013;115(9):1693-6. PubMed PMID: 23659764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease. AU - Mansouri,Leila, AU - Fekih-Mrissa,Najiba, AU - Klai,Sarra, AU - Mansour,Malek, AU - Gritli,Nasreddine, AU - Mrissa,Ridha, Y1 - 2013/05/06/ PY - 2012/07/03/received PY - 2013/03/15/revised PY - 2013/03/25/accepted PY - 2013/5/11/entrez PY - 2013/5/11/pubmed PY - 2014/4/3/medline KW - Alzheimer's disease KW - Human KW - MTHFR protein KW - Risk factor SP - 1693 EP - 6 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 115 IS - 9 N2 - BACKGROUND: Genetic risk factors play an important role in the pathogenesis of Alzheimer's disease (AD). In this case-control study, we examined the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and their correlation with this pathology. OBJECTIVE: To verify the association between MTHFR C677T and A1298C polymorphisms and Alzheimer's disease. METHOD: This work was conducted as a case-control study. Cases consisted of thirty-eight patients and 100 individuals without dementia constituted the control group. Genotyping of MTHFR polymorphisms was performed on patients and controls. RESULT: Genetic analyses did not indicate a significant association between the MTHFR C677T mutation and AD (C/T: 63.15% versus 39%, p=0.087). However, the genotype prevalence of the missense variant MTHFR A1298C was significantly different between patients and controls (A/C: 55% versus 7%, p<10(-3)). Our data suggest an association between the MTHFR A1298C mutation and AD; however, the MTHFR C677T mutation did not contribute to susceptibility for AD. CONCLUSION: The MTHFR A1298C polymorphism is a possible risk factor for Alzheimer's disease. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/23659764/Association_of_methylenetetrahydrofolate_reductase_polymorphisms_with_susceptibility_to_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(13)00121-2 DB - PRIME DP - Unbound Medicine ER -