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Association of sodium and potassium intake with ventricular arrhythmic burden in patients with essential hypertension.
J Am Soc Hypertens. 2013 Jul-Aug; 7(4):276-82.JA

Abstract

BACKGROUND

Hypertensive populations suffer from an increased susceptibility to ventricular arrhythmias and sudden cardiac death. A high-salt diet appears to be a major factor involved in cardiovascular complications in hypertension. We examined the relationship between dietary salt and potassium, as indicated by urinary sodium (UNa), urinary potassium (UK), and urinary sodium/potassium ratio (UNa/K), and the arrhythmic burden in patients with essential hypertension.

METHODS

We included 255 consecutive adult patients with well-controlled hypertension who were being followed in the hypertension outpatient clinic of a university tertiary hospital and complained of episodes of atypical chest pain and/or palpitations. All underwent 24-hour ambulatory electrocardiograph monitoring and their UNa, UK, and UNa/K ratio from 24-hour urinary excretion specimens were evaluated.

RESULTS

No significant correlation was found between premature supraventricular contractions and the parameters that were examined. However, the percentage of premature ventricular contractions (PVC%) showed a weak positive association with UNa (r = 0.2; P = .001) and a moderate negative association with UK (r = -0.396; P < .001). The partial correlation coefficient of PVC% with the UNa/UK ratio remained significant even after controlling for left ventricular mass index (r = 0.437; P < .001).

CONCLUSIONS

A higher UNa/UK excretion ratio is significantly associated with PVCs, indicating an increased susceptibility to ventricular arrhythmias even among hypertensives with well-controlled blood pressure. Our findings reinforce recommendations for dietary interventions in those populations.

Authors+Show Affiliations

Department of Cardiology, University Hospital of Heraklion, Crete, Greece. maryemarke@yahoo.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23659779

Citation

Marketou, Maria E., et al. "Association of Sodium and Potassium Intake With Ventricular Arrhythmic Burden in Patients With Essential Hypertension." Journal of the American Society of Hypertension : JASH, vol. 7, no. 4, 2013, pp. 276-82.
Marketou ME, Zacharis EA, Parthenakis F, et al. Association of sodium and potassium intake with ventricular arrhythmic burden in patients with essential hypertension. J Am Soc Hypertens. 2013;7(4):276-82.
Marketou, M. E., Zacharis, E. A., Parthenakis, F., Kochiadakis, G. E., Maragkoudakis, S., Chlouverakis, G., & Vardas, P. E. (2013). Association of sodium and potassium intake with ventricular arrhythmic burden in patients with essential hypertension. Journal of the American Society of Hypertension : JASH, 7(4), 276-82. https://doi.org/10.1016/j.jash.2013.04.002
Marketou ME, et al. Association of Sodium and Potassium Intake With Ventricular Arrhythmic Burden in Patients With Essential Hypertension. J Am Soc Hypertens. 2013 Jul-Aug;7(4):276-82. PubMed PMID: 23659779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of sodium and potassium intake with ventricular arrhythmic burden in patients with essential hypertension. AU - Marketou,Maria E, AU - Zacharis,Evangelos A, AU - Parthenakis,Fragiskos, AU - Kochiadakis,George E, AU - Maragkoudakis,Spyros, AU - Chlouverakis,Gregory, AU - Vardas,Panos E, Y1 - 2013/05/07/ PY - 2012/12/08/received PY - 2013/04/03/revised PY - 2013/04/03/accepted PY - 2013/5/11/entrez PY - 2013/5/11/pubmed PY - 2014/3/13/medline KW - Essential hypertension KW - urinary potassium KW - urinary sodium KW - ventricular arrhythmias SP - 276 EP - 82 JF - Journal of the American Society of Hypertension : JASH JO - J Am Soc Hypertens VL - 7 IS - 4 N2 - BACKGROUND: Hypertensive populations suffer from an increased susceptibility to ventricular arrhythmias and sudden cardiac death. A high-salt diet appears to be a major factor involved in cardiovascular complications in hypertension. We examined the relationship between dietary salt and potassium, as indicated by urinary sodium (UNa), urinary potassium (UK), and urinary sodium/potassium ratio (UNa/K), and the arrhythmic burden in patients with essential hypertension. METHODS: We included 255 consecutive adult patients with well-controlled hypertension who were being followed in the hypertension outpatient clinic of a university tertiary hospital and complained of episodes of atypical chest pain and/or palpitations. All underwent 24-hour ambulatory electrocardiograph monitoring and their UNa, UK, and UNa/K ratio from 24-hour urinary excretion specimens were evaluated. RESULTS: No significant correlation was found between premature supraventricular contractions and the parameters that were examined. However, the percentage of premature ventricular contractions (PVC%) showed a weak positive association with UNa (r = 0.2; P = .001) and a moderate negative association with UK (r = -0.396; P < .001). The partial correlation coefficient of PVC% with the UNa/UK ratio remained significant even after controlling for left ventricular mass index (r = 0.437; P < .001). CONCLUSIONS: A higher UNa/UK excretion ratio is significantly associated with PVCs, indicating an increased susceptibility to ventricular arrhythmias even among hypertensives with well-controlled blood pressure. Our findings reinforce recommendations for dietary interventions in those populations. SN - 1878-7436 UR - https://www.unboundmedicine.com/medline/citation/23659779/Association_of_sodium_and_potassium_intake_with_ventricular_arrhythmic_burden_in_patients_with_essential_hypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1933-1711(13)00070-3 DB - PRIME DP - Unbound Medicine ER -