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Follicular mucinosis and follicular mycosis fungoides: clinicopathological evaluation of seven cases.
Turk Patoloji Derg. 2013; 29(2):108-16.TP

Abstract

OBJECTIVE

Follicular mucinosis is a disease characterized by follicular degeneration and mucin accumulation. It can be seen in mycosis fungoides, although idiopathic or forms associated with other diseases are also known. Follicular mycosis fungoides is a type of mycosis fungoides with different clinicopathological and prognostic features.

MATERIAL AND METHOD

Seven cases with follicular centered lesions and multiple biopsies (2-6) were included. Cases were evaluated according to their clinical, histological and immunophenotypical features and follow-up data.

RESULTS

All cases were male, and the mean age was 40.3 (range 18-61). Clinical complaints were follicular prominence, erythema and alopecia at head and neck, trunk, and lower limbs. Follicular mucinosis (6/7), and dermal lymphoid infiltration showing minimal-intensive folliculotropism accompanied by eosinophils was seen. Lymphoid infiltration was composed of small-medium sized cells, with scattered hyperchromatic nuclei in six cases. In one case there was only minimal cytological atypia. Intense folliculotropism of atypical lymphocytes and dense dermal infiltration without follicular mucinosis was seen in one case. Local and/or systemic treatments were applied and partial remission was achieved histologically. In three cases new and increasing lesions were seen. Density of infiltration and atypia were increased.

CONCLUSION

The findings supported the opinion that follicular mucinosis is an important finding seen in mycosis fungoides. There can be important differences concerning the amount of infiltration and degree of atypia. In cases where the density of infiltration associated with follicular mucinosis is not diagnostic for MF, there can be progression over time. Long-term follow up is necessary in such cases where the differential diagnosis is difficult.

Authors+Show Affiliations

Department of Pathology, Ege University, Faculty of Medicine, İzmir, Turkey. drbanuyaman@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23661347

Citation

Yaman, Banu, et al. "Follicular Mucinosis and Follicular Mycosis Fungoides: Clinicopathological Evaluation of Seven Cases." Turk Patoloji Dergisi, vol. 29, no. 2, 2013, pp. 108-16.
Yaman B, Gerçeker Türk B, Öztürk G, et al. Follicular mucinosis and follicular mycosis fungoides: clinicopathological evaluation of seven cases. Turk Patoloji Derg. 2013;29(2):108-16.
Yaman, B., Gerçeker Türk, B., Öztürk, G., Ertam, I., Kandıloğlu, G., & Akalin, T. (2013). Follicular mucinosis and follicular mycosis fungoides: clinicopathological evaluation of seven cases. Turk Patoloji Dergisi, 29(2), 108-16. https://doi.org/10.5146/tjpath.2013.01160
Yaman B, et al. Follicular Mucinosis and Follicular Mycosis Fungoides: Clinicopathological Evaluation of Seven Cases. Turk Patoloji Derg. 2013;29(2):108-16. PubMed PMID: 23661347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follicular mucinosis and follicular mycosis fungoides: clinicopathological evaluation of seven cases. AU - Yaman,Banu, AU - Gerçeker Türk,Bengü, AU - Öztürk,Günseli, AU - Ertam,Ilgen, AU - Kandıloğlu,Gülşen, AU - Akalin,Taner, PY - 2013/5/11/entrez PY - 2013/5/11/pubmed PY - 2013/12/16/medline SP - 108 EP - 16 JF - Turk patoloji dergisi JO - Turk Patoloji Derg VL - 29 IS - 2 N2 - OBJECTIVE: Follicular mucinosis is a disease characterized by follicular degeneration and mucin accumulation. It can be seen in mycosis fungoides, although idiopathic or forms associated with other diseases are also known. Follicular mycosis fungoides is a type of mycosis fungoides with different clinicopathological and prognostic features. MATERIAL AND METHOD: Seven cases with follicular centered lesions and multiple biopsies (2-6) were included. Cases were evaluated according to their clinical, histological and immunophenotypical features and follow-up data. RESULTS: All cases were male, and the mean age was 40.3 (range 18-61). Clinical complaints were follicular prominence, erythema and alopecia at head and neck, trunk, and lower limbs. Follicular mucinosis (6/7), and dermal lymphoid infiltration showing minimal-intensive folliculotropism accompanied by eosinophils was seen. Lymphoid infiltration was composed of small-medium sized cells, with scattered hyperchromatic nuclei in six cases. In one case there was only minimal cytological atypia. Intense folliculotropism of atypical lymphocytes and dense dermal infiltration without follicular mucinosis was seen in one case. Local and/or systemic treatments were applied and partial remission was achieved histologically. In three cases new and increasing lesions were seen. Density of infiltration and atypia were increased. CONCLUSION: The findings supported the opinion that follicular mucinosis is an important finding seen in mycosis fungoides. There can be important differences concerning the amount of infiltration and degree of atypia. In cases where the density of infiltration associated with follicular mucinosis is not diagnostic for MF, there can be progression over time. Long-term follow up is necessary in such cases where the differential diagnosis is difficult. SN - 1309-5730 UR - https://www.unboundmedicine.com/medline/citation/23661347/Follicular_mucinosis_and_follicular_mycosis_fungoides:_clinicopathological_evaluation_of_seven_cases_ L2 - http://dx.doi.org/10.5146/tjpath.2013.01160 DB - PRIME DP - Unbound Medicine ER -