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Growth hormone therapy with norditropin (somatropin) in growth hormone deficiency.
Expert Opin Biol Ther 2013; 13(6):927-32EO

Abstract

INTRODUCTION

Growth hormone (GH) is indicated for therapy of growth hormone deficiency (GHD) in pediatric and adult patients. Introduction of recombinant human GH (rhGH) improved access to GH therapy. Norditropin [ somatropin (rDNA origin) injection] is rhGH, used for the replacement of endogenous GH in children and adults with GHD.

AREAS COVERED

The article reviews rhGH therapy in GHD indication with focus on Norditropin Nordiflex delivery system. The goals of therapy in children are to promote linear growth and restore normal body composition. In adults with GHD rhGH restores normal body composition, improves cardiac function and normalizes cardiovascular risk factors such as low-density lipoprotein cholesterol and C-reactive protein.

EXPERT OPINION

Adverse reactions of rhGH therapy include intracranial hypertension, fluid retention, glucose intolerance, and children may experience worsening of scoliosis and slipped capital femoral epiphysis. Increased risk for intracranial tumors has also been reported in teenagers and young adults treated with radiation to the head as children for a first neoplasm. RhGH therapy requires daily injections, therefore improved ease of use of delivery devices may improve treatment outcomes. Several rhGH devices have been developed, and the Norditropin FlexPro prefilled pen is the newest delivery system which has small dose increments, does not require reconstitution and has flexible storage features.

Authors+Show Affiliations

UCLA, Pediatric Endocrinology, 10833 Le Conte Ave, Los Angeles, CA 90095-1701 , USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23662811

Citation

Pawlikowska-Haddal, Anna. "Growth Hormone Therapy With Norditropin (somatropin) in Growth Hormone Deficiency." Expert Opinion On Biological Therapy, vol. 13, no. 6, 2013, pp. 927-32.
Pawlikowska-Haddal A. Growth hormone therapy with norditropin (somatropin) in growth hormone deficiency. Expert Opin Biol Ther. 2013;13(6):927-32.
Pawlikowska-Haddal, A. (2013). Growth hormone therapy with norditropin (somatropin) in growth hormone deficiency. Expert Opinion On Biological Therapy, 13(6), pp. 927-32. doi:10.1517/14712598.2013.795941.
Pawlikowska-Haddal A. Growth Hormone Therapy With Norditropin (somatropin) in Growth Hormone Deficiency. Expert Opin Biol Ther. 2013;13(6):927-32. PubMed PMID: 23662811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growth hormone therapy with norditropin (somatropin) in growth hormone deficiency. A1 - Pawlikowska-Haddal,Anna, PY - 2013/5/14/entrez PY - 2013/5/15/pubmed PY - 2013/12/18/medline SP - 927 EP - 32 JF - Expert opinion on biological therapy JO - Expert Opin Biol Ther VL - 13 IS - 6 N2 - INTRODUCTION: Growth hormone (GH) is indicated for therapy of growth hormone deficiency (GHD) in pediatric and adult patients. Introduction of recombinant human GH (rhGH) improved access to GH therapy. Norditropin [ somatropin (rDNA origin) injection] is rhGH, used for the replacement of endogenous GH in children and adults with GHD. AREAS COVERED: The article reviews rhGH therapy in GHD indication with focus on Norditropin Nordiflex delivery system. The goals of therapy in children are to promote linear growth and restore normal body composition. In adults with GHD rhGH restores normal body composition, improves cardiac function and normalizes cardiovascular risk factors such as low-density lipoprotein cholesterol and C-reactive protein. EXPERT OPINION: Adverse reactions of rhGH therapy include intracranial hypertension, fluid retention, glucose intolerance, and children may experience worsening of scoliosis and slipped capital femoral epiphysis. Increased risk for intracranial tumors has also been reported in teenagers and young adults treated with radiation to the head as children for a first neoplasm. RhGH therapy requires daily injections, therefore improved ease of use of delivery devices may improve treatment outcomes. Several rhGH devices have been developed, and the Norditropin FlexPro prefilled pen is the newest delivery system which has small dose increments, does not require reconstitution and has flexible storage features. SN - 1744-7682 UR - https://www.unboundmedicine.com/medline/citation/23662811/Growth_hormone_therapy_with_norditropin_(somatropin)_in_growth_hormone_deficiency L2 - http://www.tandfonline.com/doi/full/10.1517/14712598.2013.795941 DB - PRIME DP - Unbound Medicine ER -