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Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder.

Abstract

A number of research studies have reported abnormal plasma fatty acid profiles in children with ADHD along with some benefit of n-3 to symptoms of ADHD. However, it is currently unclear whether (lower) long chain-polyunsaturated fatty acids (LC-PUFAs) are related to ADHD pathology or to associated behaviours. The aim of this study was to test whether (1) ADHD children have abnormal plasma LC-PUFA levels and (2) ADHD symptoms and associated behaviours are correlated with LC-PUFA levels. Seventy-two, male children with (n=29) and without a clinical diagnosis of ADHD (n=43) were compared in their plasma levels of LC-PUFA. Plasma DHA was higher in the control group prior to statistical correction. Callous-unemotional (CU) traits were found to be significantly negatively related to both eicosapentaenoic acid (EPA), and total omega-3 in the ADHD group. The findings unveil for the first time that CU and anti-social traits in ADHD are associated with lower omega-3 levels.

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  • Authors+Show Affiliations

    ,

    King's College London, Institute of Psychiatry, UK. Rachel.gow@nih.gov

    , , , , , , ,

    Source

    MeSH

    Adolescent
    Attention Deficit Disorder with Hyperactivity
    Case-Control Studies
    Child
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Humans
    Male
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23664595

    Citation

    Gow, Rachel V., et al. "Omega-3 Fatty Acids Are Inversely Related to Callous and Unemotional Traits in Adolescent Boys With Attention Deficit Hyperactivity Disorder." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 88, no. 6, 2013, pp. 411-8.
    Gow RV, Vallee-Tourangeau F, Crawford MA, et al. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 2013;88(6):411-8.
    Gow, R. V., Vallee-Tourangeau, F., Crawford, M. A., Taylor, E., Ghebremeskel, K., Bueno, A. A., ... Rubia, K. (2013). Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(6), pp. 411-8. doi:10.1016/j.plefa.2013.03.009.
    Gow RV, et al. Omega-3 Fatty Acids Are Inversely Related to Callous and Unemotional Traits in Adolescent Boys With Attention Deficit Hyperactivity Disorder. Prostaglandins Leukot Essent Fatty Acids. 2013;88(6):411-8. PubMed PMID: 23664595.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. AU - Gow,Rachel V, AU - Vallee-Tourangeau,Frederic, AU - Crawford,Michael Angus, AU - Taylor,Eric, AU - Ghebremeskel,Kebreab, AU - Bueno,Allain A, AU - Hibbeln,Joseph R, AU - Sumich,Alexander, AU - Rubia,Katya, Y1 - 2013/05/07/ PY - 2012/12/22/received PY - 2013/03/21/revised PY - 2013/03/23/accepted PY - 2013/5/14/entrez PY - 2013/5/15/pubmed PY - 2013/12/16/medline SP - 411 EP - 8 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 88 IS - 6 N2 - A number of research studies have reported abnormal plasma fatty acid profiles in children with ADHD along with some benefit of n-3 to symptoms of ADHD. However, it is currently unclear whether (lower) long chain-polyunsaturated fatty acids (LC-PUFAs) are related to ADHD pathology or to associated behaviours. The aim of this study was to test whether (1) ADHD children have abnormal plasma LC-PUFA levels and (2) ADHD symptoms and associated behaviours are correlated with LC-PUFA levels. Seventy-two, male children with (n=29) and without a clinical diagnosis of ADHD (n=43) were compared in their plasma levels of LC-PUFA. Plasma DHA was higher in the control group prior to statistical correction. Callous-unemotional (CU) traits were found to be significantly negatively related to both eicosapentaenoic acid (EPA), and total omega-3 in the ADHD group. The findings unveil for the first time that CU and anti-social traits in ADHD are associated with lower omega-3 levels. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/23664595/Omega_3_fatty_acids_are_inversely_related_to_callous_and_unemotional_traits_in_adolescent_boys_with_attention_deficit_hyperactivity_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(13)00070-7 DB - PRIME DP - Unbound Medicine ER -