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Copper/zinc and copper/selenium ratios, and oxidative stress as biochemical markers in recurrent aphthous stomatitis.
J Trace Elem Med Biol. 2013 Oct; 27(4):312-6.JT

Abstract

PROJECT

Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder characterized by recurrent, painful oral aphthae, and oxidative stress presumably contributes to its pathogenesis. The aim of this study is to scrutinize the relationship between oxidative stress and serum trace elements (copper, Cu; zinc, Zn; selenium, Se), and to evaluate the ratios of Cu/Zn and Cu/Se in this disorder.

PROCEDURE

Patients with RAS (n = 33) and age- and sex-matched healthy control subjects (n = 30) were enrolled in this study. Malondialdehyde (MDA) concentrations in plasma and the activities of superoxide dismutase (SOD1; CuZnSOD), glutathione peroxidase (GPx) and catalase (CAT) in erythrocyte were determined as spectrophotometric. Also, the levels of Se, Zn and Cu in serum were determined on flame and furnace atomic absorption spectrophotometer using Zeeman background correction.

RESULTS AND CONCLUSIONS

Oxidative stress was confirmed by the significant elevation in plasma MDA, and by the significant decrease in CAT, SOD1, and GPx (p < 0.05). When compared to controls, Zn and Se levels were significantly lower in patients, whereas Cu levels was higher in RAS patients than those in controls (p < 0.05). In addition, the correlation results of this study were firstly shown that there were significant and positive correlations between Se-CAT, Se-GPx, and Cu-MDA parameters, but negative correlations between Se-Cu, Se-MDA, Cu-CAT, Cu-SOD1 and Cu-GPx parameters in RAS patients. Furthermore, the ratios of Cu/Zn and Cu/Se were significantly higher in the patients than the control subjects (p < 0.05). Our results indicated that lipid peroxidation associated with the imbalance of the trace elements seems to play a crucial role in the pathogenesis of RAS. Furthermore, the serum Cu/Zn and Cu/Se ratios may be used as biochemical markers in these patients.

Authors+Show Affiliations

Sutcu Imam University, Medicine of Faculty, Department of Dermatology, Kahramanmaras, Turkey. Electronic address: drperihanozturk@hotmail.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23664921

Citation

Ozturk, Perihan, et al. "Copper/zinc and Copper/selenium Ratios, and Oxidative Stress as Biochemical Markers in Recurrent Aphthous Stomatitis." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 27, no. 4, 2013, pp. 312-6.
Ozturk P, Belge Kurutas E, Ataseven A. Copper/zinc and copper/selenium ratios, and oxidative stress as biochemical markers in recurrent aphthous stomatitis. J Trace Elem Med Biol. 2013;27(4):312-6.
Ozturk, P., Belge Kurutas, E., & Ataseven, A. (2013). Copper/zinc and copper/selenium ratios, and oxidative stress as biochemical markers in recurrent aphthous stomatitis. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 27(4), 312-6. https://doi.org/10.1016/j.jtemb.2013.04.002
Ozturk P, Belge Kurutas E, Ataseven A. Copper/zinc and Copper/selenium Ratios, and Oxidative Stress as Biochemical Markers in Recurrent Aphthous Stomatitis. J Trace Elem Med Biol. 2013;27(4):312-6. PubMed PMID: 23664921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Copper/zinc and copper/selenium ratios, and oxidative stress as biochemical markers in recurrent aphthous stomatitis. AU - Ozturk,Perihan, AU - Belge Kurutas,Ergul, AU - Ataseven,Arzu, Y1 - 2013/04/12/ PY - 2012/08/28/received PY - 2013/01/23/revised PY - 2013/04/03/accepted PY - 2013/5/14/entrez PY - 2013/5/15/pubmed PY - 2014/12/18/medline KW - CAT KW - Cu KW - GPx KW - MDA KW - Oxidative stress biomarkers KW - RAS KW - ROS KW - Recurrent aphthous stomatitis KW - SOD KW - Se KW - Trace elements KW - Zn KW - catalase KW - copper KW - glutation peroxidase KW - malondialdehyde KW - reactive oxygen species KW - recurrent aphthous stomatitis KW - selenium KW - superoxide dismutase KW - zinc SP - 312 EP - 6 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 27 IS - 4 N2 - PROJECT: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder characterized by recurrent, painful oral aphthae, and oxidative stress presumably contributes to its pathogenesis. The aim of this study is to scrutinize the relationship between oxidative stress and serum trace elements (copper, Cu; zinc, Zn; selenium, Se), and to evaluate the ratios of Cu/Zn and Cu/Se in this disorder. PROCEDURE: Patients with RAS (n = 33) and age- and sex-matched healthy control subjects (n = 30) were enrolled in this study. Malondialdehyde (MDA) concentrations in plasma and the activities of superoxide dismutase (SOD1; CuZnSOD), glutathione peroxidase (GPx) and catalase (CAT) in erythrocyte were determined as spectrophotometric. Also, the levels of Se, Zn and Cu in serum were determined on flame and furnace atomic absorption spectrophotometer using Zeeman background correction. RESULTS AND CONCLUSIONS: Oxidative stress was confirmed by the significant elevation in plasma MDA, and by the significant decrease in CAT, SOD1, and GPx (p < 0.05). When compared to controls, Zn and Se levels were significantly lower in patients, whereas Cu levels was higher in RAS patients than those in controls (p < 0.05). In addition, the correlation results of this study were firstly shown that there were significant and positive correlations between Se-CAT, Se-GPx, and Cu-MDA parameters, but negative correlations between Se-Cu, Se-MDA, Cu-CAT, Cu-SOD1 and Cu-GPx parameters in RAS patients. Furthermore, the ratios of Cu/Zn and Cu/Se were significantly higher in the patients than the control subjects (p < 0.05). Our results indicated that lipid peroxidation associated with the imbalance of the trace elements seems to play a crucial role in the pathogenesis of RAS. Furthermore, the serum Cu/Zn and Cu/Se ratios may be used as biochemical markers in these patients. SN - 1878-3252 UR - https://www.unboundmedicine.com/medline/citation/23664921/Copper/zinc_and_copper/selenium_ratios_and_oxidative_stress_as_biochemical_markers_in_recurrent_aphthous_stomatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(13)00051-5 DB - PRIME DP - Unbound Medicine ER -