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Desirability for a typhoid fever vaccine among rural residents, Pemba Island, Tanzania.
Vaccine. 2013 Jun 24; 31(29):2994-9.V

Abstract

BACKGROUND

Surveillance data indicate that Salmonella enterica serotype Typhi (S. Typhi) is a significant cause of morbidity and mortality in Africa. With limited anticipated short-term improvements in sanitation and water infrastructure, targeted vaccination campaigns may be an important prevention tool for typhoid fever.

METHODS

A cross-sectional survey was conducted with 435 randomly selected households in four rural villages on Pemba Island, Tanzania. A dichotomous 'readiness to pay' variable was created to assess vaccine desirability. Data analyses included univariate and bivariate descriptive statistics and binary logistic regression. Bivariate outcomes (ANOVA, t-tests, and chi-square) and odds ratios with 95% confidence intervals are reported.

RESULTS

A total of 66% respondents stated that they would pay for a typhoid fever vaccine in the future. Readiness to pay was not significantly associated with household expenditures. Readiness to pay was associated with use of local Primary Health Care Units (PHCUs) compared to use of cottage or district hospitals (OR 1.8 [95% CI, 1.2-2.7]: p=.007) and with knowledge of someone being sick from typhoid fever (OR 2.2 [95% CI, 1.0-4.5]: p=.039). Respondents perceiving prevention measures as more effective (OR 1.0 [95% CI, 1.0-1.2]: p=.009) were also more likely ready to pay. Preferred methods of communication of information about a typhoid fever vaccine included broadcasting via microphone ('miking'), radio, and door-to-door visits.

CONCLUSIONS

With rapid increase in numbers of licensed and promising vaccines, policy makers and health administrators are faced with decisions regarding allocation of scarce health resources for competing interventions. Community residents need to be informed about diseases which may not be readily recognized, diagnosed, and treated. Perceived vulnerability to the disease may increase likelihood of vaccine desirability. A better local understanding of typhoid fever is needed for general prevention measures, increasing treatment access, and future vaccination campaigns.

Authors+Show Affiliations

Pediatric Prevention Research Center, Wayne State University, 4707 St. Antoine Street, Suite W534, Detroit, MI 48201, USA. lkaljee@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23664993

Citation

Kaljee, Linda M., et al. "Desirability for a Typhoid Fever Vaccine Among Rural Residents, Pemba Island, Tanzania." Vaccine, vol. 31, no. 29, 2013, pp. 2994-9.
Kaljee LM, Pach A, Thriemer K, et al. Desirability for a typhoid fever vaccine among rural residents, Pemba Island, Tanzania. Vaccine. 2013;31(29):2994-9.
Kaljee, L. M., Pach, A., Thriemer, K., Ley, B., Jiddawi, M., Puri, M., Ochiai, L., Wierzba, T., Clemens, J., & Ali, S. M. (2013). Desirability for a typhoid fever vaccine among rural residents, Pemba Island, Tanzania. Vaccine, 31(29), 2994-9. https://doi.org/10.1016/j.vaccine.2013.04.058
Kaljee LM, et al. Desirability for a Typhoid Fever Vaccine Among Rural Residents, Pemba Island, Tanzania. Vaccine. 2013 Jun 24;31(29):2994-9. PubMed PMID: 23664993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Desirability for a typhoid fever vaccine among rural residents, Pemba Island, Tanzania. AU - Kaljee,Linda M, AU - Pach,Alfred, AU - Thriemer,Kamala, AU - Ley,Benedikt, AU - Jiddawi,Mohamed, AU - Puri,Mahesh, AU - Ochiai,Leon, AU - Wierzba,Thomas, AU - Clemens,John, AU - Ali,Said M, Y1 - 2013/05/09/ PY - 2012/12/13/received PY - 2013/03/28/revised PY - 2013/04/24/accepted PY - 2013/5/14/entrez PY - 2013/5/15/pubmed PY - 2014/2/5/medline SP - 2994 EP - 9 JF - Vaccine JO - Vaccine VL - 31 IS - 29 N2 - BACKGROUND: Surveillance data indicate that Salmonella enterica serotype Typhi (S. Typhi) is a significant cause of morbidity and mortality in Africa. With limited anticipated short-term improvements in sanitation and water infrastructure, targeted vaccination campaigns may be an important prevention tool for typhoid fever. METHODS: A cross-sectional survey was conducted with 435 randomly selected households in four rural villages on Pemba Island, Tanzania. A dichotomous 'readiness to pay' variable was created to assess vaccine desirability. Data analyses included univariate and bivariate descriptive statistics and binary logistic regression. Bivariate outcomes (ANOVA, t-tests, and chi-square) and odds ratios with 95% confidence intervals are reported. RESULTS: A total of 66% respondents stated that they would pay for a typhoid fever vaccine in the future. Readiness to pay was not significantly associated with household expenditures. Readiness to pay was associated with use of local Primary Health Care Units (PHCUs) compared to use of cottage or district hospitals (OR 1.8 [95% CI, 1.2-2.7]: p=.007) and with knowledge of someone being sick from typhoid fever (OR 2.2 [95% CI, 1.0-4.5]: p=.039). Respondents perceiving prevention measures as more effective (OR 1.0 [95% CI, 1.0-1.2]: p=.009) were also more likely ready to pay. Preferred methods of communication of information about a typhoid fever vaccine included broadcasting via microphone ('miking'), radio, and door-to-door visits. CONCLUSIONS: With rapid increase in numbers of licensed and promising vaccines, policy makers and health administrators are faced with decisions regarding allocation of scarce health resources for competing interventions. Community residents need to be informed about diseases which may not be readily recognized, diagnosed, and treated. Perceived vulnerability to the disease may increase likelihood of vaccine desirability. A better local understanding of typhoid fever is needed for general prevention measures, increasing treatment access, and future vaccination campaigns. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/23664993/Desirability_for_a_typhoid_fever_vaccine_among_rural_residents_Pemba_Island_Tanzania_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(13)00527-6 DB - PRIME DP - Unbound Medicine ER -