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Impact of new vitamin D data on future studies and treatment.
Curr Opin Nephrol Hypertens. 2013 Jul; 22(4):377-82.CO

Abstract

PURPOSE OF REVIEW

This review evaluates recently published data on clinical effects of vitamin D supplementation, focusing on randomized, placebo-controlled trials and nontraditional actions on the cardiovascular and immune systems.

RECENT FINDINGS

Several randomized trials evaluating vitamin D therapy have recently emerged, in both the general population and in individuals with chronic kidney disease (CKD). In the former, measurable effects on cardiovascular risk factors have not been detected, with the possible exception of a modest reduction in blood pressure. Studies aimed at boosting immunity have demonstrated efficacy only in specific, high-risk populations. In CKD, the benefits of nutritional vitamin D appear largely limited to earlier stages of disease. Benefits of active vitamin D agents, outside of their known effects on mineral metabolism, have also thus far eluded detection. One possible exception that has accumulated supportive evidence is the link between active vitamin D analogs and decreased proteinuria. Large-scale clinical trials, now underway, will be critical to understanding of the potential benefits and hazards of vitamin D treatment.

SUMMARY

New trials evaluating the effects of vitamin D supplementation have failed to reveal any robust clinical benefits beyond its known actions on mineral and bone disease.

Authors+Show Affiliations

Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. ibhan@partners.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23666416

Citation

Bhan, Ishir, et al. "Impact of New Vitamin D Data On Future Studies and Treatment." Current Opinion in Nephrology and Hypertension, vol. 22, no. 4, 2013, pp. 377-82.
Bhan I, Tamez H, Thadhani R. Impact of new vitamin D data on future studies and treatment. Curr Opin Nephrol Hypertens. 2013;22(4):377-82.
Bhan, I., Tamez, H., & Thadhani, R. (2013). Impact of new vitamin D data on future studies and treatment. Current Opinion in Nephrology and Hypertension, 22(4), 377-82. https://doi.org/10.1097/MNH.0b013e3283621408
Bhan I, Tamez H, Thadhani R. Impact of New Vitamin D Data On Future Studies and Treatment. Curr Opin Nephrol Hypertens. 2013;22(4):377-82. PubMed PMID: 23666416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of new vitamin D data on future studies and treatment. AU - Bhan,Ishir, AU - Tamez,Hector, AU - Thadhani,Ravi, PY - 2013/5/14/entrez PY - 2013/5/15/pubmed PY - 2014/1/11/medline SP - 377 EP - 82 JF - Current opinion in nephrology and hypertension JO - Curr Opin Nephrol Hypertens VL - 22 IS - 4 N2 - PURPOSE OF REVIEW: This review evaluates recently published data on clinical effects of vitamin D supplementation, focusing on randomized, placebo-controlled trials and nontraditional actions on the cardiovascular and immune systems. RECENT FINDINGS: Several randomized trials evaluating vitamin D therapy have recently emerged, in both the general population and in individuals with chronic kidney disease (CKD). In the former, measurable effects on cardiovascular risk factors have not been detected, with the possible exception of a modest reduction in blood pressure. Studies aimed at boosting immunity have demonstrated efficacy only in specific, high-risk populations. In CKD, the benefits of nutritional vitamin D appear largely limited to earlier stages of disease. Benefits of active vitamin D agents, outside of their known effects on mineral metabolism, have also thus far eluded detection. One possible exception that has accumulated supportive evidence is the link between active vitamin D analogs and decreased proteinuria. Large-scale clinical trials, now underway, will be critical to understanding of the potential benefits and hazards of vitamin D treatment. SUMMARY: New trials evaluating the effects of vitamin D supplementation have failed to reveal any robust clinical benefits beyond its known actions on mineral and bone disease. SN - 1473-6543 UR - https://www.unboundmedicine.com/medline/citation/23666416/Impact_of_new_vitamin_D_data_on_future_studies_and_treatment_ L2 - https://doi.org/10.1097/MNH.0b013e3283621408 DB - PRIME DP - Unbound Medicine ER -