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Preparation and properties of cellulose nanocrystals reinforced collagen composite films.
J Biomed Mater Res A. 2014 Apr; 102(4):1131-9.JB

Abstract

Collagen films have been widely used in the field of biomedical engineering. However, the poor mechanical properties of collagen have limited its application. Here, rod-like cellulose nanocrystals (CNCs) were fabricated and used to reinforce collagen films. A series of collagen/CNCs films were prepared by collagen solution with CNCs suspensions homogeneously dispersed at CNCs: collagen weight ratios of 1, 3, 5, 7, and 10. The morphology of the resulting films was analyzed by scanning electron microscopy (SEM), the enhancement of the thermomechanical properties of the collagen/CNCs composites were demonstrated by thermal gravimetric analysis (TGA) and mechanical testing. Among the CNCs contents used, a loading of 7 wt % led to the maximum mechanical properties for the collagen/CNCs composite films. In addition, in vitro cell culture studies revealed that the CNCs have no negative effect on the cell morphology, viability, and proliferation and possess good biocompatibility. We conclude that the incorporation of CNCs is a simple and promising way to reinforce collagen films without impairing biocompatibility. This study demonstrates that the composite films show good potential for use in the field of skin tissue engineering.

Authors+Show Affiliations

Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China; Department of Chemistry, Jinan University, Guangzhou, 510632, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23666851

Citation

Li, Weichang, et al. "Preparation and Properties of Cellulose Nanocrystals Reinforced Collagen Composite Films." Journal of Biomedical Materials Research. Part A, vol. 102, no. 4, 2014, pp. 1131-9.
Li W, Guo R, Lan Y, et al. Preparation and properties of cellulose nanocrystals reinforced collagen composite films. J Biomed Mater Res A. 2014;102(4):1131-9.
Li, W., Guo, R., Lan, Y., Zhang, Y., Xue, W., & Zhang, Y. (2014). Preparation and properties of cellulose nanocrystals reinforced collagen composite films. Journal of Biomedical Materials Research. Part A, 102(4), 1131-9. https://doi.org/10.1002/jbm.a.34792
Li W, et al. Preparation and Properties of Cellulose Nanocrystals Reinforced Collagen Composite Films. J Biomed Mater Res A. 2014;102(4):1131-9. PubMed PMID: 23666851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and properties of cellulose nanocrystals reinforced collagen composite films. AU - Li,Weichang, AU - Guo,Rui, AU - Lan,Yong, AU - Zhang,Yi, AU - Xue,Wei, AU - Zhang,Yuanming, Y1 - 2013/06/28/ PY - 2013/02/07/received PY - 2013/04/07/revised PY - 2013/05/02/accepted PY - 2013/5/14/entrez PY - 2013/5/15/pubmed PY - 2014/10/24/medline KW - biocompatibility KW - cellulose nanocrystals (CNCs) KW - collagen KW - composite films KW - mechanical strength SP - 1131 EP - 9 JF - Journal of biomedical materials research. Part A JO - J Biomed Mater Res A VL - 102 IS - 4 N2 - Collagen films have been widely used in the field of biomedical engineering. However, the poor mechanical properties of collagen have limited its application. Here, rod-like cellulose nanocrystals (CNCs) were fabricated and used to reinforce collagen films. A series of collagen/CNCs films were prepared by collagen solution with CNCs suspensions homogeneously dispersed at CNCs: collagen weight ratios of 1, 3, 5, 7, and 10. The morphology of the resulting films was analyzed by scanning electron microscopy (SEM), the enhancement of the thermomechanical properties of the collagen/CNCs composites were demonstrated by thermal gravimetric analysis (TGA) and mechanical testing. Among the CNCs contents used, a loading of 7 wt % led to the maximum mechanical properties for the collagen/CNCs composite films. In addition, in vitro cell culture studies revealed that the CNCs have no negative effect on the cell morphology, viability, and proliferation and possess good biocompatibility. We conclude that the incorporation of CNCs is a simple and promising way to reinforce collagen films without impairing biocompatibility. This study demonstrates that the composite films show good potential for use in the field of skin tissue engineering. SN - 1552-4965 UR - https://www.unboundmedicine.com/medline/citation/23666851/Preparation_and_properties_of_cellulose_nanocrystals_reinforced_collagen_composite_films_ L2 - https://doi.org/10.1002/jbm.a.34792 DB - PRIME DP - Unbound Medicine ER -