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Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats.
J Neurogastroenterol Motil 2013; 19(2):161-70JN

Abstract

BACKGROUND/AIMS

Type 1 diabetes is often accompanied by gastrointestinal motility disturbances. Vagal neuropathy, hyperglycemia, and alterations in the myenteric plexus have been proposed as underlying mechanism. We therefore studied the relationship between vagal function, gastrointestinal motiliy and characteristics of the enteric nervous system in the biobreeding (BB) rat known as model for spontaneous type 1 diabetes.

METHODS

Gastric emptying breath test, small intestinal electromyography, relative risk-interval variability, histology and immunohistochemistry on antral and jejunal segments were performed at 1, 8 and 16 weeks after diabetes onset and on age-matched controls.

RESULTS

We observed no consistent changes in relative risk-interval variability and gastric emptying rate. There was however, a loss of phases 3 with longer duration of diabetes on small intestinal electromyography. We found a progressive decrease of nitrergic neurons in the myenteric plexus of antrum and jejunum, while numbers of cholinergic nerve were not altered. In addition, a transient inflammatory infiltrate in jejunal wall was found in spontaneous diabetic BB rats at 8 weeks of diabetes.

CONCLUSIONS

In diabetic BB rats, altered small intestinal motor control associated with a loss of myenteric nitric oxide synthase expression occurs, which does not depend on hyperglycemia or vagal dysfunction, and which is preceded by transient intestinal inflammation.

Authors+Show Affiliations

Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23667747

Citation

Demedts, Ingrid, et al. "Gastrointestinal Motility Changes and Myenteric Plexus Alterations in Spontaneously Diabetic Biobreeding Rats." Journal of Neurogastroenterology and Motility, vol. 19, no. 2, 2013, pp. 161-70.
Demedts I, Masaoka T, Kindt S, et al. Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats. J Neurogastroenterol Motil. 2013;19(2):161-70.
Demedts, I., Masaoka, T., Kindt, S., De Hertogh, G., Geboes, K., Farré, R., ... Tack, J. (2013). Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats. Journal of Neurogastroenterology and Motility, 19(2), pp. 161-70. doi:10.5056/jnm.2013.19.2.161.
Demedts I, et al. Gastrointestinal Motility Changes and Myenteric Plexus Alterations in Spontaneously Diabetic Biobreeding Rats. J Neurogastroenterol Motil. 2013;19(2):161-70. PubMed PMID: 23667747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats. AU - Demedts,Ingrid, AU - Masaoka,Tatsuhiro, AU - Kindt,Sebastien, AU - De Hertogh,Gert, AU - Geboes,Karel, AU - Farré,Ricard, AU - Vanden Berghe,Pieter, AU - Tack,Jan, Y1 - 2013/04/16/ PY - 2012/08/27/received PY - 2012/12/17/revised PY - 2013/01/02/accepted PY - 2013/5/14/entrez PY - 2013/5/15/pubmed PY - 2013/5/15/medline KW - Diabetes mellitus KW - Electromyography KW - Enteric nervous system KW - Gastric empyting KW - Rats, inbred BB SP - 161 EP - 70 JF - Journal of neurogastroenterology and motility JO - J Neurogastroenterol Motil VL - 19 IS - 2 N2 - BACKGROUND/AIMS: Type 1 diabetes is often accompanied by gastrointestinal motility disturbances. Vagal neuropathy, hyperglycemia, and alterations in the myenteric plexus have been proposed as underlying mechanism. We therefore studied the relationship between vagal function, gastrointestinal motiliy and characteristics of the enteric nervous system in the biobreeding (BB) rat known as model for spontaneous type 1 diabetes. METHODS: Gastric emptying breath test, small intestinal electromyography, relative risk-interval variability, histology and immunohistochemistry on antral and jejunal segments were performed at 1, 8 and 16 weeks after diabetes onset and on age-matched controls. RESULTS: We observed no consistent changes in relative risk-interval variability and gastric emptying rate. There was however, a loss of phases 3 with longer duration of diabetes on small intestinal electromyography. We found a progressive decrease of nitrergic neurons in the myenteric plexus of antrum and jejunum, while numbers of cholinergic nerve were not altered. In addition, a transient inflammatory infiltrate in jejunal wall was found in spontaneous diabetic BB rats at 8 weeks of diabetes. CONCLUSIONS: In diabetic BB rats, altered small intestinal motor control associated with a loss of myenteric nitric oxide synthase expression occurs, which does not depend on hyperglycemia or vagal dysfunction, and which is preceded by transient intestinal inflammation. SN - 2093-0879 UR - https://www.unboundmedicine.com/medline/citation/23667747/Gastrointestinal_motility_changes_and_myenteric_plexus_alterations_in_spontaneously_diabetic_biobreeding_rats_ L2 - http://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm.2013.19.2.161 DB - PRIME DP - Unbound Medicine ER -