Tags

Type your tag names separated by a space and hit enter

Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC).
Ann Oncol. 2013 Aug; 24(8):2166-73.AO

Abstract

BACKGROUND

While higher intake of fish and lower consumption of red/processed meats have been suggested to play a protective role in the etiology of several cancers, prospective evidence for hepatocellular carcinoma (HCC) is limited, particularly in Western European populations.

METHODS

The associations of fish and meats with HCC risk were analyzed in the EPIC cohort. Between 1992 and 2010, 191 incident HCC were identified among 477 206 participants. Baseline diet was assessed using validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for calibration. Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured.

RESULTS

HCC risk was inversely associated with intake of total fish (per 20 g/day increase, HR = 0.83, 95% CI 0.74-0.95 and HR = 0.80, 95% CI 0.69-0.97 before and after calibration, respectively). This inverse association was also suggested after adjusting for HBV/HCV status and liver function score (per 20-g/day increase, RR = 0.86, 95% CI 0.66-1.11 and RR = 0.74, 95% CI 0.50-1.09, respectively) in a nested case-control subset. Intakes of total meats or subgroups of red/processed meats, and poultry were not associated with HCC risk.

CONCLUSIONS

In this large European cohort, total fish intake is associated with lower HCC risk.

Authors+Show Affiliations

Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France. nep@iarc.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23670094

Citation

Fedirko, V, et al. "Consumption of Fish and Meats and Risk of Hepatocellular Carcinoma: the European Prospective Investigation Into Cancer and Nutrition (EPIC)." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 24, no. 8, 2013, pp. 2166-73.
Fedirko V, Trichopolou A, Bamia C, et al. Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC). Ann Oncol. 2013;24(8):2166-73.
Fedirko, V., Trichopolou, A., Bamia, C., Duarte-Salles, T., Trepo, E., Aleksandrova, K., Nöthlings, U., Lukanova, A., Lagiou, P., Boffetta, P., Trichopoulos, D., Katzke, V. A., Overvad, K., Tjønneland, A., Hansen, L., Boutron-Ruault, M. C., Fagherazzi, G., Bastide, N., Panico, S., ... Jenab, M. (2013). Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC). Annals of Oncology : Official Journal of the European Society for Medical Oncology, 24(8), 2166-73. https://doi.org/10.1093/annonc/mdt168
Fedirko V, et al. Consumption of Fish and Meats and Risk of Hepatocellular Carcinoma: the European Prospective Investigation Into Cancer and Nutrition (EPIC). Ann Oncol. 2013;24(8):2166-73. PubMed PMID: 23670094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC). AU - Fedirko,V, AU - Trichopolou,A, AU - Bamia,C, AU - Duarte-Salles,T, AU - Trepo,E, AU - Aleksandrova,K, AU - Nöthlings,U, AU - Lukanova,A, AU - Lagiou,P, AU - Boffetta,P, AU - Trichopoulos,D, AU - Katzke,V A, AU - Overvad,K, AU - Tjønneland,A, AU - Hansen,L, AU - Boutron-Ruault,M C, AU - Fagherazzi,G, AU - Bastide,N, AU - Panico,S, AU - Grioni,S, AU - Vineis,P, AU - Palli,D, AU - Tumino,R, AU - Bueno-de-Mesquita,H B, AU - Peeters,P H, AU - Skeie,G, AU - Engeset,D, AU - Parr,C L, AU - Jakszyn,P, AU - Sánchez,M J, AU - Barricarte,A, AU - Amiano,P, AU - Chirlaque,M, AU - Quirós,J R, AU - Sund,M, AU - Werner,M, AU - Sonestedt,E, AU - Ericson,U, AU - Key,T J, AU - Khaw,K T, AU - Ferrari,P, AU - Romieu,I, AU - Riboli,E, AU - Jenab,M, Y1 - 2013/05/12/ PY - 2013/5/15/entrez PY - 2013/5/15/pubmed PY - 2014/4/23/medline KW - cohort study KW - diet KW - fish intake KW - hepatocellular carcinoma KW - meat intake SP - 2166 EP - 73 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 24 IS - 8 N2 - BACKGROUND: While higher intake of fish and lower consumption of red/processed meats have been suggested to play a protective role in the etiology of several cancers, prospective evidence for hepatocellular carcinoma (HCC) is limited, particularly in Western European populations. METHODS: The associations of fish and meats with HCC risk were analyzed in the EPIC cohort. Between 1992 and 2010, 191 incident HCC were identified among 477 206 participants. Baseline diet was assessed using validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for calibration. Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured. RESULTS: HCC risk was inversely associated with intake of total fish (per 20 g/day increase, HR = 0.83, 95% CI 0.74-0.95 and HR = 0.80, 95% CI 0.69-0.97 before and after calibration, respectively). This inverse association was also suggested after adjusting for HBV/HCV status and liver function score (per 20-g/day increase, RR = 0.86, 95% CI 0.66-1.11 and RR = 0.74, 95% CI 0.50-1.09, respectively) in a nested case-control subset. Intakes of total meats or subgroups of red/processed meats, and poultry were not associated with HCC risk. CONCLUSIONS: In this large European cohort, total fish intake is associated with lower HCC risk. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/23670094/Consumption_of_fish_and_meats_and_risk_of_hepatocellular_carcinoma:_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0923-7534(19)36829-2 DB - PRIME DP - Unbound Medicine ER -