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Population-based analysis of prognostic indicators in sebaceous carcinoma of the head and neck.
Laryngoscope. 2013 Sep; 123(9):2165-9.L

Abstract

OBJECTIVES/HYPOTHESIS

Due to the rarity of sebaceous carcinoma of the head and neck, few large series have been reported and prognostic factors remain largely undetermined. This study presents prognostic factors in survival in sebaceous carcinoma of the head and neck.

STUDY DESIGN

Retrospective analysis was performed using the Surveillance Epidemiology and End Results (SEER) database for patients diagnosed with sebaceous carcinoma of the head and neck (SCHN).

METHODS

Clinicopathologic, treatment data, and 5-year disease specific survival were analyzed using univariable and multivariable regression analysis and Kaplan-Meier methodology.

RESULTS

Of the 1,433 patients identified to have SCHN, 16 were node-positive (1.14%). On multivariable analysis, independent prognostic indicators were: age at diagnosis (HR = 1.03, P = .021), tumor grade (HR = 4.97, P = .038), and distant metastasis (HR = 7.52, P = .006). Nodal metastasis occurred exclusively with poorly or undifferentiated tumors and was not a significant prognostic factor on multivariable analysis.

CONCLUSION

Elderly patients and patients with poorly differentiated tumors and/or distant disease at presentation have the highest risk of disease-specific mortality. Lymph node metastasis does not appear to be an independent prognostic factor in sebaceous cell carcinoma.

Authors+Show Affiliations

College of Medicine, Medical University of South Carolina, Charleston, South Carolina, U.S.A.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

23670399

Citation

Thomas, W Walsh, et al. "Population-based Analysis of Prognostic Indicators in Sebaceous Carcinoma of the Head and Neck." The Laryngoscope, vol. 123, no. 9, 2013, pp. 2165-9.
Thomas WW, Fritsch VA, Lentsch EJ. Population-based analysis of prognostic indicators in sebaceous carcinoma of the head and neck. Laryngoscope. 2013;123(9):2165-9.
Thomas, W. W., Fritsch, V. A., & Lentsch, E. J. (2013). Population-based analysis of prognostic indicators in sebaceous carcinoma of the head and neck. The Laryngoscope, 123(9), 2165-9. https://doi.org/10.1002/lary.24042
Thomas WW, Fritsch VA, Lentsch EJ. Population-based Analysis of Prognostic Indicators in Sebaceous Carcinoma of the Head and Neck. Laryngoscope. 2013;123(9):2165-9. PubMed PMID: 23670399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Population-based analysis of prognostic indicators in sebaceous carcinoma of the head and neck. AU - Thomas,W Walsh, AU - Fritsch,Valerie A, AU - Lentsch,Eric J, Y1 - 2013/05/13/ PY - 2012/10/29/received PY - 2012/12/09/revised PY - 2013/01/15/accepted PY - 2013/5/15/entrez PY - 2013/5/15/pubmed PY - 2013/12/16/medline KW - SEER database KW - Sebaceous carcinoma KW - head and neck KW - prognostic factors SP - 2165 EP - 9 JF - The Laryngoscope JO - Laryngoscope VL - 123 IS - 9 N2 - OBJECTIVES/HYPOTHESIS: Due to the rarity of sebaceous carcinoma of the head and neck, few large series have been reported and prognostic factors remain largely undetermined. This study presents prognostic factors in survival in sebaceous carcinoma of the head and neck. STUDY DESIGN: Retrospective analysis was performed using the Surveillance Epidemiology and End Results (SEER) database for patients diagnosed with sebaceous carcinoma of the head and neck (SCHN). METHODS: Clinicopathologic, treatment data, and 5-year disease specific survival were analyzed using univariable and multivariable regression analysis and Kaplan-Meier methodology. RESULTS: Of the 1,433 patients identified to have SCHN, 16 were node-positive (1.14%). On multivariable analysis, independent prognostic indicators were: age at diagnosis (HR = 1.03, P = .021), tumor grade (HR = 4.97, P = .038), and distant metastasis (HR = 7.52, P = .006). Nodal metastasis occurred exclusively with poorly or undifferentiated tumors and was not a significant prognostic factor on multivariable analysis. CONCLUSION: Elderly patients and patients with poorly differentiated tumors and/or distant disease at presentation have the highest risk of disease-specific mortality. Lymph node metastasis does not appear to be an independent prognostic factor in sebaceous cell carcinoma. SN - 1531-4995 UR - https://www.unboundmedicine.com/medline/citation/23670399/Population_based_analysis_of_prognostic_indicators_in_sebaceous_carcinoma_of_the_head_and_neck_ L2 - https://doi.org/10.1002/lary.24042 DB - PRIME DP - Unbound Medicine ER -