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Antibacterial sesquiterpenoid derivatives from Ferula ferulaeoides.
Planta Med. 2013 May; 79(8):701-6.PM

Abstract

Three new sesquiterpenoid derivatives 1, 2, and 3 were isolated from Ferula ferulaeoides. To confirm the structure, compound 2 was also synthesized via a condensation reaction between compound 1 and 2,2-dimethoxypropane. The structures of these three compounds were elucidated by means of spectroscopic and chemical methods. Their antibacterial activity against drug-resistant Staphylococcus aureus strains were evaluated with MIC values in the range of 0.5-128 µg/mL. Compounds 1 and 3 were capable of inhibiting efflux of ethidium bromide using an in vitro assay. The cytotoxicity of the compounds was evaluated on cultured HEK293 cells, and none of them showed toxicity to HEK293 cells at a concentration of 125 µg/mL.

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Authors+Show Affiliations

Liu T
School of Pharmacy, Fudan University, Shanghai, China.
Osman K
No affiliation info available
Kaatz GW
No affiliation info available
Gibbons S
No affiliation info available
Mu Q
No affiliation info available

MeSH

Anti-Bacterial AgentsDrug Screening Assays, AntitumorFerulaHEK293 CellsHumansMicrobial Sensitivity TestsMolecular StructureSesquiterpenesStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23670622

Citation

Liu, Tao, et al. "Antibacterial Sesquiterpenoid Derivatives From Ferula Ferulaeoides." Planta Medica, vol. 79, no. 8, 2013, pp. 701-6.
Liu T, Osman K, Kaatz GW, et al. Antibacterial sesquiterpenoid derivatives from Ferula ferulaeoides. Planta Med. 2013;79(8):701-6.
Liu, T., Osman, K., Kaatz, G. W., Gibbons, S., & Mu, Q. (2013). Antibacterial sesquiterpenoid derivatives from Ferula ferulaeoides. Planta Medica, 79(8), 701-6. https://doi.org/10.1055/s-0032-1328461
Liu T, et al. Antibacterial Sesquiterpenoid Derivatives From Ferula Ferulaeoides. Planta Med. 2013;79(8):701-6. PubMed PMID: 23670622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial sesquiterpenoid derivatives from Ferula ferulaeoides. AU - Liu,Tao, AU - Osman,Khadijo, AU - Kaatz,Glenn W, AU - Gibbons,Simon, AU - Mu,Qing, Y1 - 2013/05/13/ PY - 2013/5/15/entrez PY - 2013/5/15/pubmed PY - 2013/12/18/medline SP - 701 EP - 6 JF - Planta medica JO - Planta Med VL - 79 IS - 8 N2 - Three new sesquiterpenoid derivatives 1, 2, and 3 were isolated from Ferula ferulaeoides. To confirm the structure, compound 2 was also synthesized via a condensation reaction between compound 1 and 2,2-dimethoxypropane. The structures of these three compounds were elucidated by means of spectroscopic and chemical methods. Their antibacterial activity against drug-resistant Staphylococcus aureus strains were evaluated with MIC values in the range of 0.5-128 µg/mL. Compounds 1 and 3 were capable of inhibiting efflux of ethidium bromide using an in vitro assay. The cytotoxicity of the compounds was evaluated on cultured HEK293 cells, and none of them showed toxicity to HEK293 cells at a concentration of 125 µg/mL. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/23670622/Antibacterial_sesquiterpenoid_derivatives_from_Ferula_ferulaeoides_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0032-1328461 DB - PRIME DP - Unbound Medicine ER -