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Therapeutic effect of probiotic dahi on plasma, aortic, and hepatic lipid profile of hypercholesterolemic rats.

Abstract

This study examined the effects of probiotic dahi prepared by Lactobacillus plantarum Lp9 and dahi culture in buffalo milk on lowering cholesterol in rats fed a hypercholesterolemic basal diet. Male Wistar rats were divided into 3 groups and fed with probiotic dahi, dahi, or buffalo milk for 120 days. Following the consumption of supplements (probiotic dahi, dahi or buffalo milk), the animals were fed a basal hypercholesterolemic diet. Plasma total cholesterol and triglycerides (TAGs) were decreased by 35% and 72% in rats fed with probiotic dahi group, while cholesterol levels increased by 70% and TAGs increased by 97% in buffalo milk and 59% in dahi fed groups. Supplementation of probiotic dahi further lowered plasma low-density lipoprotein (LDL) + very-low-density lipoprotein (VLDL)- cholesterol by 59%, while it elevated plasma high-density lipoprotein (HDL)-cholesterol by 116%. As a result, atherogenic index, the ratio of HDL to LDL + VLDL was markedly improved. Deposition of cholesterol and TAGs in liver and aorta were significantly reduced in rats fed with probiotic dahi. These observations suggest that probiotic dahi may have therapeutic potential to decrease plasma, hepatic and aortic lipid profile, and attenuate diet-induced hypercholesterolemia.

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  • Authors+Show Affiliations

    ,

    Animal Biochemistry Division, National Dairy Research Institute, Karnal, Haryana, India. dmohania@gmail.com

    , , , , , ,

    Source

    MeSH

    Animals
    Aorta
    Buffaloes
    Cholesterol
    Dietary Supplements
    Disease Models, Animal
    Hypercholesterolemia
    Lactobacillus plantarum
    Lipids
    Lipoproteins, HDL
    Lipoproteins, LDL
    Liver
    Male
    Milk
    Probiotics
    Rats
    Rats, Wistar
    Triglycerides

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23671271

    Citation

    Mohania, Dheeraj, et al. "Therapeutic Effect of Probiotic Dahi On Plasma, Aortic, and Hepatic Lipid Profile of Hypercholesterolemic Rats." Journal of Cardiovascular Pharmacology and Therapeutics, vol. 18, no. 5, 2013, pp. 490-7.
    Mohania D, Kansal VK, Shah D, et al. Therapeutic effect of probiotic dahi on plasma, aortic, and hepatic lipid profile of hypercholesterolemic rats. J Cardiovasc Pharmacol Ther. 2013;18(5):490-7.
    Mohania, D., Kansal, V. K., Shah, D., Nagpal, R., Kumar, M., Gautam, S. K., ... Behare, P. V. (2013). Therapeutic effect of probiotic dahi on plasma, aortic, and hepatic lipid profile of hypercholesterolemic rats. Journal of Cardiovascular Pharmacology and Therapeutics, 18(5), pp. 490-7. doi:10.1177/1074248413487431.
    Mohania D, et al. Therapeutic Effect of Probiotic Dahi On Plasma, Aortic, and Hepatic Lipid Profile of Hypercholesterolemic Rats. J Cardiovasc Pharmacol Ther. 2013;18(5):490-7. PubMed PMID: 23671271.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Therapeutic effect of probiotic dahi on plasma, aortic, and hepatic lipid profile of hypercholesterolemic rats. AU - Mohania,Dheeraj, AU - Kansal,Vinod Kumar, AU - Shah,Dilip, AU - Nagpal,Ravinder, AU - Kumar,Manoj, AU - Gautam,Sanjeev Kumar, AU - Singh,Birbal, AU - Behare,Pradip Vishnu, Y1 - 2013/05/12/ PY - 2013/5/15/entrez PY - 2013/5/15/pubmed PY - 2014/6/12/medline KW - Lactobacillus plantarum KW - cardiovascular disease KW - probiotics SP - 490 EP - 7 JF - Journal of cardiovascular pharmacology and therapeutics JO - J. Cardiovasc. Pharmacol. Ther. VL - 18 IS - 5 N2 - This study examined the effects of probiotic dahi prepared by Lactobacillus plantarum Lp9 and dahi culture in buffalo milk on lowering cholesterol in rats fed a hypercholesterolemic basal diet. Male Wistar rats were divided into 3 groups and fed with probiotic dahi, dahi, or buffalo milk for 120 days. Following the consumption of supplements (probiotic dahi, dahi or buffalo milk), the animals were fed a basal hypercholesterolemic diet. Plasma total cholesterol and triglycerides (TAGs) were decreased by 35% and 72% in rats fed with probiotic dahi group, while cholesterol levels increased by 70% and TAGs increased by 97% in buffalo milk and 59% in dahi fed groups. Supplementation of probiotic dahi further lowered plasma low-density lipoprotein (LDL) + very-low-density lipoprotein (VLDL)- cholesterol by 59%, while it elevated plasma high-density lipoprotein (HDL)-cholesterol by 116%. As a result, atherogenic index, the ratio of HDL to LDL + VLDL was markedly improved. Deposition of cholesterol and TAGs in liver and aorta were significantly reduced in rats fed with probiotic dahi. These observations suggest that probiotic dahi may have therapeutic potential to decrease plasma, hepatic and aortic lipid profile, and attenuate diet-induced hypercholesterolemia. SN - 1940-4034 UR - https://www.unboundmedicine.com/medline/citation/23671271/Therapeutic_effect_of_probiotic_dahi_on_plasma_aortic_and_hepatic_lipid_profile_of_hypercholesterolemic_rats_ L2 - http://journals.sagepub.com/doi/full/10.1177/1074248413487431?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -