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Isolation and antifungal properties of cyclo(D-Tyr-L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode.
Nat Prod Res. 2013; 27(23):2168-72.NP

Abstract

Bacillus sp. associated with an entomopathogenic nematode is shown to produce diketopiperazine (DKP) that showed stronger antifungal activity against Colletotrichum gloeosporioides [minimum inhibitory concentration (MIC): 8 μg mL(- 1)] than commercial fungicide oligochitosan (MIC: 125 μg mL(- 1)). DKP identified as cyclo(D-Tyr-L-Leu) was isolated for the first time from a natural source with a d-tyrosine residue. This report also demonstrates for the first time an antifungal property exploration of cyclo(Tyr-Leu) class of dipeptides. The structural elucidation was carried out using 1D, 2D NMR methods and HPLC.

Authors+Show Affiliations

a National Institute for Interdisciplinary Science and Technology (NIIST), CSIR , Thiruvananthapuram , 695 019 , Kerala India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23672207

Citation

Kumar, Nishanth, et al. "Isolation and Antifungal Properties of cyclo(D-Tyr-L-Leu) Diketopiperazine Isolated From Bacillus Sp. Associated With Rhabditid Entomopathogenic Nematode." Natural Product Research, vol. 27, no. 23, 2013, pp. 2168-72.
Kumar N, Gorantla JN, Mohandas C, et al. Isolation and antifungal properties of cyclo(D-Tyr-L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode. Nat Prod Res. 2013;27(23):2168-72.
Kumar, N., Gorantla, J. N., Mohandas, C., Nambisan, B., & Lankalapalli, R. S. (2013). Isolation and antifungal properties of cyclo(D-Tyr-L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode. Natural Product Research, 27(23), 2168-72. https://doi.org/10.1080/14786419.2013.796466
Kumar N, et al. Isolation and Antifungal Properties of cyclo(D-Tyr-L-Leu) Diketopiperazine Isolated From Bacillus Sp. Associated With Rhabditid Entomopathogenic Nematode. Nat Prod Res. 2013;27(23):2168-72. PubMed PMID: 23672207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation and antifungal properties of cyclo(D-Tyr-L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode. AU - Kumar,Nishanth, AU - Gorantla,Jaggaiah N, AU - Mohandas,C, AU - Nambisan,Bala, AU - Lankalapalli,Ravi S, Y1 - 2013/05/14/ PY - 2013/5/16/entrez PY - 2013/5/16/pubmed PY - 2014/7/30/medline SP - 2168 EP - 72 JF - Natural product research JO - Nat Prod Res VL - 27 IS - 23 N2 - Bacillus sp. associated with an entomopathogenic nematode is shown to produce diketopiperazine (DKP) that showed stronger antifungal activity against Colletotrichum gloeosporioides [minimum inhibitory concentration (MIC): 8 μg mL(- 1)] than commercial fungicide oligochitosan (MIC: 125 μg mL(- 1)). DKP identified as cyclo(D-Tyr-L-Leu) was isolated for the first time from a natural source with a d-tyrosine residue. This report also demonstrates for the first time an antifungal property exploration of cyclo(Tyr-Leu) class of dipeptides. The structural elucidation was carried out using 1D, 2D NMR methods and HPLC. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/23672207/Isolation_and_antifungal_properties_of_cyclo_D_Tyr_L_Leu__diketopiperazine_isolated_from_Bacillus_sp__associated_with_rhabditid_entomopathogenic_nematode_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2013.796466 DB - PRIME DP - Unbound Medicine ER -