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Greater intake of fruit and vegetables is associated with a lower risk of osteoporotic hip fractures in elderly Chinese: a 1:1 matched case-control study.

Abstract

In this case-control study, we examined the relationship between the consumption of fruit and vegetables and risk of hip fractures in 646 pairs of incident cases and controls in elderly Chinese. We found that greater consumption of both fruit and vegetables in men and vegetables in women was associated with a lower risk of osteoporotic hip fractures in elderly Chinese.

INTRODUCTION

The association between fruit and vegetable consumption and the risk of osteoporotic fractures remains controversial due to limited published evidence. The purpose of this study was to determine whether consuming fruits and vegetables has a protective effect against hip fractures.

METHODS

Between January 2008 and December 2012, 646 (162 males, 484 females) incident cases (70.9 ± 6.8 years) of hip fractures were enrolled from five hospitals, with 646 sex- and age-matched (±3 years) controls (70.7 ± 6.8 years) from hospitals or the community. Face-to-face interviews were conducted to assess habitual dietary intakes using a 79-item food frequency questionnaire and various covariates by structured questionnaires.

RESULTS

Multivariate conditional logistic regression analyses showed dose-dependent inverse correlations between the intake of total fruit (p-trend = 0.014), total vegetables (p-trend <0.001), fruits and vegetables combined (p-trend < 0.001) and the risk of hip fractures after adjustment for sociodemographic characteristics, dietary factors and other potential confounders. The adjusted odds ratios (95% confidence interval) for hip fractures in the top quartiles (vs. the lowest quartiles) for the intake of fruits, vegetables and the combination of fruits and vegetables were 0.53 (0.32-0.87), 0.37 (0.23-0.60) and 0.25 (0.15-0.41), respectively. Stratified analyses showed that the benefits remained significant in males (p = 0.001) but not in females (p = 0.210) (p-interaction 0.045). Among the subcategories of fruits and vegetables, similar associations were observed for all subgroups except light-coloured fruits.

CONCLUSIONS

Our findings suggest that greater consumption of both fruits and vegetables in men and vegetables in women may decrease the risk of osteoporotic hip fractures in elderly Chinese.

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  • Authors+Show Affiliations

    ,

    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.

    , , , , , , ,

    Source

    MeSH

    Aged
    Case-Control Studies
    China
    Diet
    Diet Surveys
    Feeding Behavior
    Female
    Fruit
    Hip Fractures
    Humans
    Life Style
    Male
    Middle Aged
    Motor Activity
    Osteoporotic Fractures
    Risk Assessment
    Socioeconomic Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23673464

    Citation

    Xie, H-L, et al. "Greater Intake of Fruit and Vegetables Is Associated With a Lower Risk of Osteoporotic Hip Fractures in Elderly Chinese: a 1:1 Matched Case-control Study." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 24, no. 11, 2013, pp. 2827-36.
    Xie HL, Wu BH, Xue WQ, et al. Greater intake of fruit and vegetables is associated with a lower risk of osteoporotic hip fractures in elderly Chinese: a 1:1 matched case-control study. Osteoporos Int. 2013;24(11):2827-36.
    Xie, H. L., Wu, B. H., Xue, W. Q., He, M. G., Fan, F., Ouyang, W. F., ... Chen, Y. M. (2013). Greater intake of fruit and vegetables is associated with a lower risk of osteoporotic hip fractures in elderly Chinese: a 1:1 matched case-control study. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 24(11), pp. 2827-36. doi:10.1007/s00198-013-2383-9.
    Xie HL, et al. Greater Intake of Fruit and Vegetables Is Associated With a Lower Risk of Osteoporotic Hip Fractures in Elderly Chinese: a 1:1 Matched Case-control Study. Osteoporos Int. 2013;24(11):2827-36. PubMed PMID: 23673464.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Greater intake of fruit and vegetables is associated with a lower risk of osteoporotic hip fractures in elderly Chinese: a 1:1 matched case-control study. AU - Xie,H-L, AU - Wu,B-H, AU - Xue,W-Q, AU - He,M-G, AU - Fan,F, AU - Ouyang,W-F, AU - Tu,S-L, AU - Zhu,H-L, AU - Chen,Y-M, Y1 - 2013/05/15/ PY - 2012/08/21/received PY - 2013/03/18/accepted PY - 2013/5/16/entrez PY - 2013/5/16/pubmed PY - 2014/8/13/medline SP - 2827 EP - 36 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 24 IS - 11 N2 - UNLABELLED: In this case-control study, we examined the relationship between the consumption of fruit and vegetables and risk of hip fractures in 646 pairs of incident cases and controls in elderly Chinese. We found that greater consumption of both fruit and vegetables in men and vegetables in women was associated with a lower risk of osteoporotic hip fractures in elderly Chinese. INTRODUCTION: The association between fruit and vegetable consumption and the risk of osteoporotic fractures remains controversial due to limited published evidence. The purpose of this study was to determine whether consuming fruits and vegetables has a protective effect against hip fractures. METHODS: Between January 2008 and December 2012, 646 (162 males, 484 females) incident cases (70.9 ± 6.8 years) of hip fractures were enrolled from five hospitals, with 646 sex- and age-matched (±3 years) controls (70.7 ± 6.8 years) from hospitals or the community. Face-to-face interviews were conducted to assess habitual dietary intakes using a 79-item food frequency questionnaire and various covariates by structured questionnaires. RESULTS: Multivariate conditional logistic regression analyses showed dose-dependent inverse correlations between the intake of total fruit (p-trend = 0.014), total vegetables (p-trend <0.001), fruits and vegetables combined (p-trend < 0.001) and the risk of hip fractures after adjustment for sociodemographic characteristics, dietary factors and other potential confounders. The adjusted odds ratios (95% confidence interval) for hip fractures in the top quartiles (vs. the lowest quartiles) for the intake of fruits, vegetables and the combination of fruits and vegetables were 0.53 (0.32-0.87), 0.37 (0.23-0.60) and 0.25 (0.15-0.41), respectively. Stratified analyses showed that the benefits remained significant in males (p = 0.001) but not in females (p = 0.210) (p-interaction 0.045). Among the subcategories of fruits and vegetables, similar associations were observed for all subgroups except light-coloured fruits. CONCLUSIONS: Our findings suggest that greater consumption of both fruits and vegetables in men and vegetables in women may decrease the risk of osteoporotic hip fractures in elderly Chinese. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/23673464/Greater_intake_of_fruit_and_vegetables_is_associated_with_a_lower_risk_of_osteoporotic_hip_fractures_in_elderly_Chinese:_a_1:1_matched_case_control_study_ L2 - https://dx.doi.org/10.1007/s00198-013-2383-9 DB - PRIME DP - Unbound Medicine ER -