Tags

Type your tag names separated by a space and hit enter

Color Doppler imaging analysis of retrobulbar blood flow velocities in primary open-angle glaucomatous eyes: a meta-analysis.
PLoS One. 2013; 8(5):e62723.Plos

Abstract

BACKGROUND

To analyze the diagnostic value of color Doppler imaging (CDI) of blood flow in the retrobulbar vessels of eyes with primary open-angle glaucoma (POAG).

METHODS

Pertinent publications were retrieved from the Cochrane Central Register of Controlled Trials, PubMed and the ISI Web of Knowledge up to October 2012. Changes in peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI) of the ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary artery (SPCA) of POAG eyes and normal controls were evaluated by CDI. Subgroup analyses were conducted according to whether patients received IOP-lowering drugs treatment and were defined as treated and untreated.

RESULTS

PSV and EDV were statistically significantly reduced in the OA of POAG eyes (P = 0.0002; P<0.00001; respectively), with significant heterogeneity (P(heterogeneity)<0.00001, I² = 94%; P(heterogeneity)<0.00001, I² = 85%; respectively). Similar results were demonstrated for the CRA (P<0.00001; respectively) and SPCA (P = 0.005; P<0.00001; respectively), with significant heterogeneities for both the CRA (P(heterogeneity)<0.00001, I² = 81%; P(heterogeneity)<0.00001, I² = 98%; respectively) and the SPCA (P(heterogeneity)<0.00001, I² = 96%; P(heterogeneity)<0.00001, I² = 93%; respectively). Significant increases in RI were found in all retrobulbar vessels (P<0.00001; respectively), with significant heterogeneities (P(heterogeneity)<0.00001, I² = 95%; P(heterogeneity)<0.00001, I² = 94%; P(heterogeneity)<0.00001, I² = 97%; respectively).

CONCLUSIONS

This meta-analysis suggests that CDI is a potential diagnostic tool for POAG.

Authors+Show Affiliations

Department of Health Care, Qilu Hospital of Shandong University, Jinan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23675419

Citation

Meng, Nana, et al. "Color Doppler Imaging Analysis of Retrobulbar Blood Flow Velocities in Primary Open-angle Glaucomatous Eyes: a Meta-analysis." PloS One, vol. 8, no. 5, 2013, pp. e62723.
Meng N, Zhang P, Huang H, et al. Color Doppler imaging analysis of retrobulbar blood flow velocities in primary open-angle glaucomatous eyes: a meta-analysis. PLoS One. 2013;8(5):e62723.
Meng, N., Zhang, P., Huang, H., Ma, J., Zhang, Y., Li, H., & Qu, Y. (2013). Color Doppler imaging analysis of retrobulbar blood flow velocities in primary open-angle glaucomatous eyes: a meta-analysis. PloS One, 8(5), e62723. https://doi.org/10.1371/journal.pone.0062723
Meng N, et al. Color Doppler Imaging Analysis of Retrobulbar Blood Flow Velocities in Primary Open-angle Glaucomatous Eyes: a Meta-analysis. PLoS One. 2013;8(5):e62723. PubMed PMID: 23675419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Color Doppler imaging analysis of retrobulbar blood flow velocities in primary open-angle glaucomatous eyes: a meta-analysis. AU - Meng,Nana, AU - Zhang,Ping, AU - Huang,Huadong, AU - Ma,Jinlan, AU - Zhang,Yue, AU - Li,Hao, AU - Qu,Yi, Y1 - 2013/05/13/ PY - 2012/12/19/received PY - 2013/03/25/accepted PY - 2013/5/16/entrez PY - 2013/5/16/pubmed PY - 2013/12/16/medline SP - e62723 EP - e62723 JF - PloS one JO - PLoS One VL - 8 IS - 5 N2 - BACKGROUND: To analyze the diagnostic value of color Doppler imaging (CDI) of blood flow in the retrobulbar vessels of eyes with primary open-angle glaucoma (POAG). METHODS: Pertinent publications were retrieved from the Cochrane Central Register of Controlled Trials, PubMed and the ISI Web of Knowledge up to October 2012. Changes in peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI) of the ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary artery (SPCA) of POAG eyes and normal controls were evaluated by CDI. Subgroup analyses were conducted according to whether patients received IOP-lowering drugs treatment and were defined as treated and untreated. RESULTS: PSV and EDV were statistically significantly reduced in the OA of POAG eyes (P = 0.0002; P<0.00001; respectively), with significant heterogeneity (P(heterogeneity)<0.00001, I² = 94%; P(heterogeneity)<0.00001, I² = 85%; respectively). Similar results were demonstrated for the CRA (P<0.00001; respectively) and SPCA (P = 0.005; P<0.00001; respectively), with significant heterogeneities for both the CRA (P(heterogeneity)<0.00001, I² = 81%; P(heterogeneity)<0.00001, I² = 98%; respectively) and the SPCA (P(heterogeneity)<0.00001, I² = 96%; P(heterogeneity)<0.00001, I² = 93%; respectively). Significant increases in RI were found in all retrobulbar vessels (P<0.00001; respectively), with significant heterogeneities (P(heterogeneity)<0.00001, I² = 95%; P(heterogeneity)<0.00001, I² = 94%; P(heterogeneity)<0.00001, I² = 97%; respectively). CONCLUSIONS: This meta-analysis suggests that CDI is a potential diagnostic tool for POAG. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23675419/Color_Doppler_imaging_analysis_of_retrobulbar_blood_flow_velocities_in_primary_open_angle_glaucomatous_eyes:_a_meta_analysis_ L2 - https://dx.plos.org/10.1371/journal.pone.0062723 DB - PRIME DP - Unbound Medicine ER -