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Cardiac amyloidosis presenting with prolonged QT interval and recurrent polymorphic ventricular tachycardia.
Tex Heart Inst J. 2013; 40(2):193-5.TH

Abstract

Cardiac amyloidosis results in severely symptomatic heart failure that has a poor prognosis because of the development of a restrictive cardiomyopathy. The diagnosis of cardiac amyloidosis is often delayed because of nonspecific signs and symptoms. We report the case of a 66-year-old woman who had been diagnosed with sick sinus syndrome and presented 5 months later with a long QT interval and recurrent polymorphic ventricular tachycardia. The diagnosis of cardiac amyloidosis was confirmed upon analysis of endomyocardial biopsy results. The patient was subsequently diagnosed with and treated for underlying plasma cell myeloma and later died of cardiac arrest. This atypical presentation of cardiac amyloidosis underscores the need to consider it in the differential diagnosis of patients who have ventricular arrhythmias. To our knowledge, the combination of long QT interval and polymorphic ventricular tachycardia has not been previously reported in association with amyloid heart disease.

Authors+Show Affiliations

Division of Cardiology, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. naggarw2@jhmi.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Video-Audio Media

Language

eng

PubMed ID

23678221

Citation

Gilotra, Nisha A., et al. "Cardiac Amyloidosis Presenting With Prolonged QT Interval and Recurrent Polymorphic Ventricular Tachycardia." Texas Heart Institute Journal, vol. 40, no. 2, 2013, pp. 193-5.
Gilotra NA, Chow GV, Cingolani OH. Cardiac amyloidosis presenting with prolonged QT interval and recurrent polymorphic ventricular tachycardia. Tex Heart Inst J. 2013;40(2):193-5.
Gilotra, N. A., Chow, G. V., & Cingolani, O. H. (2013). Cardiac amyloidosis presenting with prolonged QT interval and recurrent polymorphic ventricular tachycardia. Texas Heart Institute Journal, 40(2), 193-5.
Gilotra NA, Chow GV, Cingolani OH. Cardiac Amyloidosis Presenting With Prolonged QT Interval and Recurrent Polymorphic Ventricular Tachycardia. Tex Heart Inst J. 2013;40(2):193-5. PubMed PMID: 23678221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac amyloidosis presenting with prolonged QT interval and recurrent polymorphic ventricular tachycardia. AU - Gilotra,Nisha A, AU - Chow,Grant V, AU - Cingolani,Oscar H, PY - 2013/5/17/entrez PY - 2013/5/17/pubmed PY - 2013/12/24/medline KW - Amyloidosis/complications/diagnosis/etiology KW - cardiomyopathies/diagnosis/therapy KW - diagnosis, differential KW - tachycardia, ventricular/etiology/therapy SP - 193 EP - 5 JF - Texas Heart Institute journal JO - Tex Heart Inst J VL - 40 IS - 2 N2 - Cardiac amyloidosis results in severely symptomatic heart failure that has a poor prognosis because of the development of a restrictive cardiomyopathy. The diagnosis of cardiac amyloidosis is often delayed because of nonspecific signs and symptoms. We report the case of a 66-year-old woman who had been diagnosed with sick sinus syndrome and presented 5 months later with a long QT interval and recurrent polymorphic ventricular tachycardia. The diagnosis of cardiac amyloidosis was confirmed upon analysis of endomyocardial biopsy results. The patient was subsequently diagnosed with and treated for underlying plasma cell myeloma and later died of cardiac arrest. This atypical presentation of cardiac amyloidosis underscores the need to consider it in the differential diagnosis of patients who have ventricular arrhythmias. To our knowledge, the combination of long QT interval and polymorphic ventricular tachycardia has not been previously reported in association with amyloid heart disease. SN - 1526-6702 UR - https://www.unboundmedicine.com/medline/citation/23678221/Cardiac_amyloidosis_presenting_with_prolonged_QT_interval_and_recurrent_polymorphic_ventricular_tachycardia_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=23678221.ui DB - PRIME DP - Unbound Medicine ER -