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Assessment of biofilm by nasal cytology in different forms of rhinitis and its functional correlations.
Eur Ann Allergy Clin Immunol. 2013 Feb; 45(1):25-9.EA

Abstract

BACKGROUND

Recently, it has been reported that nasal cytology in light microscopy can identify biofilms, which appear as cyan-stained "Infectious Spots". We assessed by the same method and in the same population, the presence of biofilms in different nasal disorders, and estimated if a correlation with the functional grade of obstruction existed.

METHODS

Subjects suffering from different nasal disorders, after a detailed clinical history and ENT examination, underwent nasal fibroendoscopy, skin prick test, rhinomanometry and nasal cytology. The presence of biofilm was linked to the type ofdisease and to the grade of obstruction.

RESULTS

Among 1,410 subjects previously studied, the infectious spot was found in 107 patients (7.6%), and this percentage reached 55.4% in subjects with cytologic signs of infectious rhinitis (presence of bacteria/fungi). Biofilms were largely more frequent in patients with adenoid hypertrophy (57.4%), followed by nasal polyposis (24%), chronic rhinosinusitis (9.5%) and non-allergic rhinitis (7.6%). Nasal cytology was normal in the remaining patients, where no infectious spot was detectable. Statistical analysis showed that nasal resistances were significantly higher in presence of biofilms in patients with adenoid hypertrophy (p = 0.003), nasal polyposis (p < 0.001), chronic rhinosinusitis (p = 0.018) and septal deviation (p = 0.001).

CONCLUSION

The results demonstrate that biofilm is present not only in infectious rhinitis, but also in inflammatory and/or immune-mediated diseases. The presence of biofilms significantly correlates with the degree of nasal obstruction as assessed by rhinomanometry.

Authors+Show Affiliations

Department of Otolaryngology, University of Bari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23678556

Citation

Gelardi, M, et al. "Assessment of Biofilm By Nasal Cytology in Different Forms of Rhinitis and Its Functional Correlations." European Annals of Allergy and Clinical Immunology, vol. 45, no. 1, 2013, pp. 25-9.
Gelardi M, Passalacqua G, Fiorella ML, et al. Assessment of biofilm by nasal cytology in different forms of rhinitis and its functional correlations. Eur Ann Allergy Clin Immunol. 2013;45(1):25-9.
Gelardi, M., Passalacqua, G., Fiorella, M. L., & Quaranta, N. (2013). Assessment of biofilm by nasal cytology in different forms of rhinitis and its functional correlations. European Annals of Allergy and Clinical Immunology, 45(1), 25-9.
Gelardi M, et al. Assessment of Biofilm By Nasal Cytology in Different Forms of Rhinitis and Its Functional Correlations. Eur Ann Allergy Clin Immunol. 2013;45(1):25-9. PubMed PMID: 23678556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of biofilm by nasal cytology in different forms of rhinitis and its functional correlations. AU - Gelardi,M, AU - Passalacqua,G, AU - Fiorella,M L, AU - Quaranta,N, PY - 2013/5/18/entrez PY - 2013/5/18/pubmed PY - 2013/6/19/medline SP - 25 EP - 9 JF - European annals of allergy and clinical immunology JO - Eur Ann Allergy Clin Immunol VL - 45 IS - 1 N2 - BACKGROUND: Recently, it has been reported that nasal cytology in light microscopy can identify biofilms, which appear as cyan-stained "Infectious Spots". We assessed by the same method and in the same population, the presence of biofilms in different nasal disorders, and estimated if a correlation with the functional grade of obstruction existed. METHODS: Subjects suffering from different nasal disorders, after a detailed clinical history and ENT examination, underwent nasal fibroendoscopy, skin prick test, rhinomanometry and nasal cytology. The presence of biofilm was linked to the type ofdisease and to the grade of obstruction. RESULTS: Among 1,410 subjects previously studied, the infectious spot was found in 107 patients (7.6%), and this percentage reached 55.4% in subjects with cytologic signs of infectious rhinitis (presence of bacteria/fungi). Biofilms were largely more frequent in patients with adenoid hypertrophy (57.4%), followed by nasal polyposis (24%), chronic rhinosinusitis (9.5%) and non-allergic rhinitis (7.6%). Nasal cytology was normal in the remaining patients, where no infectious spot was detectable. Statistical analysis showed that nasal resistances were significantly higher in presence of biofilms in patients with adenoid hypertrophy (p = 0.003), nasal polyposis (p < 0.001), chronic rhinosinusitis (p = 0.018) and septal deviation (p = 0.001). CONCLUSION: The results demonstrate that biofilm is present not only in infectious rhinitis, but also in inflammatory and/or immune-mediated diseases. The presence of biofilms significantly correlates with the degree of nasal obstruction as assessed by rhinomanometry. SN - 1764-1489 UR - https://www.unboundmedicine.com/medline/citation/23678556/Assessment_of_biofilm_by_nasal_cytology_in_different_forms_of_rhinitis_and_its_functional_correlations_ DB - PRIME DP - Unbound Medicine ER -