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Lipid peroxidation markers in adult attention deficit hyperactivity disorder: new findings for oxidative stress.

Abstract

Malondialdehyde (MDA) is a reliable marker of lipid peroxidation where paraoxonase and arylesterase are two enzymes against it. Although increased MDA has been previously shown in adults with attention deficit/hyperactivity disorder (A-ADHD), levels of paraoxonase and arylesterase enzymes have not been studied yet. We aimed to determine the status of both MDA level and paraoxonase and arylesterase enzyme activities in A-ADHD patients. A total of 35 adults with ADHD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV) criteria and 29 healthy volunteers were included in the study. Serum MDA, paraoxonase and arylesterase levels of the participants were measured. The disease severity of the patients was determined by using Turgay's Adult Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD) DSM IV Based Diagnostic Screening and Rating Scale. The serum MDA level of patients was significantly higher than that of healthy control subjects, whereas their paraoxonase and arylesterase levels were significantly lower. There was no correlation between the levels of biochemical parameters (MDA, paraoxonase and arylesterase) and the disease severity. Sub-types of A-ADHD were similar in terms of these biochemical parameters. Increased lipid peroxidation, a part of oxidative stress, in adults with ADHD appears to be unbuffered by antioxidant enzymes, namely paraoxonase and arylesterase.

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  • Authors+Show Affiliations

    ,

    Dicle University, Faculty of Medicine, Psychiatry Department, Diyarbakir, Turkey.

    , , , , , ,

    Source

    Psychiatry research 209:3 2013 Oct 30 pg 638-42

    MeSH

    Adult
    Aryldialkylphosphatase
    Attention Deficit Disorder with Hyperactivity
    Carboxylic Ester Hydrolases
    Female
    Humans
    Lipid Peroxidation
    Male
    Malondialdehyde
    Oxidative Stress
    Personality Disorders
    Psychiatric Status Rating Scales
    Statistics, Nonparametric
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23680468

    Citation

    Bulut, Mahmut, et al. "Lipid Peroxidation Markers in Adult Attention Deficit Hyperactivity Disorder: New Findings for Oxidative Stress." Psychiatry Research, vol. 209, no. 3, 2013, pp. 638-42.
    Bulut M, Selek S, Bez Y, et al. Lipid peroxidation markers in adult attention deficit hyperactivity disorder: new findings for oxidative stress. Psychiatry Res. 2013;209(3):638-42.
    Bulut, M., Selek, S., Bez, Y., Cemal Kaya, M., Gunes, M., Karababa, F., ... Savas, H. A. (2013). Lipid peroxidation markers in adult attention deficit hyperactivity disorder: new findings for oxidative stress. Psychiatry Research, 209(3), pp. 638-42. doi:10.1016/j.psychres.2013.02.025.
    Bulut M, et al. Lipid Peroxidation Markers in Adult Attention Deficit Hyperactivity Disorder: New Findings for Oxidative Stress. Psychiatry Res. 2013 Oct 30;209(3):638-42. PubMed PMID: 23680468.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lipid peroxidation markers in adult attention deficit hyperactivity disorder: new findings for oxidative stress. AU - Bulut,Mahmut, AU - Selek,Salih, AU - Bez,Yasin, AU - Cemal Kaya,Mehmet, AU - Gunes,Mehmet, AU - Karababa,Fatih, AU - Celik,Hakim, AU - Savas,Haluk Asuman, Y1 - 2013/05/13/ PY - 2012/05/28/received PY - 2012/12/03/revised PY - 2013/02/22/accepted PY - 2013/5/18/entrez PY - 2013/5/18/pubmed PY - 2014/5/31/medline KW - Adult ADHD KW - Arylesterase KW - Lipid peroxidation KW - Malondialdehyde KW - Oxidative stress KW - Paraoxonase SP - 638 EP - 42 JF - Psychiatry research JO - Psychiatry Res VL - 209 IS - 3 N2 - Malondialdehyde (MDA) is a reliable marker of lipid peroxidation where paraoxonase and arylesterase are two enzymes against it. Although increased MDA has been previously shown in adults with attention deficit/hyperactivity disorder (A-ADHD), levels of paraoxonase and arylesterase enzymes have not been studied yet. We aimed to determine the status of both MDA level and paraoxonase and arylesterase enzyme activities in A-ADHD patients. A total of 35 adults with ADHD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV) criteria and 29 healthy volunteers were included in the study. Serum MDA, paraoxonase and arylesterase levels of the participants were measured. The disease severity of the patients was determined by using Turgay's Adult Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD) DSM IV Based Diagnostic Screening and Rating Scale. The serum MDA level of patients was significantly higher than that of healthy control subjects, whereas their paraoxonase and arylesterase levels were significantly lower. There was no correlation between the levels of biochemical parameters (MDA, paraoxonase and arylesterase) and the disease severity. Sub-types of A-ADHD were similar in terms of these biochemical parameters. Increased lipid peroxidation, a part of oxidative stress, in adults with ADHD appears to be unbuffered by antioxidant enzymes, namely paraoxonase and arylesterase. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/23680468/Lipid_peroxidation_markers_in_adult_attention_deficit_hyperactivity_disorder:_new_findings_for_oxidative_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(13)00099-1 DB - PRIME DP - Unbound Medicine ER -