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Gastro-floating tablets of cephalexin: preparation and in vitro/in vivo evaluation.
Int J Pharm. 2013 Aug 16; 452(1-2):241-8.IJ

Abstract

Gastro-floating tablets of cephalexin were developed to prolong the residence time in major absorption sites. Gastro-floating tablets were prepared and optimized using hydroxypropyl methylcellulose (HPMC K100M) as matrix and sodium bicarbonate as a gas-forming agent. The properties of the tablets in terms of floating lag time, floating time and in vitro release were evaluated. Furthermore, in vivo pharmacokinetic study in fed and fasted beagle dogs was performed. The gastro-floating tablets had short floating lag time and exhibited a satisfactory sustained-release profile in vitro. Compared with conventional capsules, the gastro-floating tablets presented a sustained-release behavior with a relative bioavailability of 99.4%, while the reference sustained-release tablets gave a relative bioavailability of only 39.3%. Meanwhile, the food had significant effect on the pharmacokinetics of sustained-release tablets. It was concluded that the gastro-floating tablets had a sustained-release effect in vitro and in vivo, as well as desired pharmacokinetic properties in both fed and fasted conditions.

Authors+Show Affiliations

Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23680730

Citation

Yin, Lifang, et al. "Gastro-floating Tablets of Cephalexin: Preparation and in Vitro/in Vivo Evaluation." International Journal of Pharmaceutics, vol. 452, no. 1-2, 2013, pp. 241-8.
Yin L, Qin C, Chen K, et al. Gastro-floating tablets of cephalexin: preparation and in vitro/in vivo evaluation. Int J Pharm. 2013;452(1-2):241-8.
Yin, L., Qin, C., Chen, K., Zhu, C., Cao, H., Zhou, J., He, W., & Zhang, Q. (2013). Gastro-floating tablets of cephalexin: preparation and in vitro/in vivo evaluation. International Journal of Pharmaceutics, 452(1-2), 241-8. https://doi.org/10.1016/j.ijpharm.2013.05.011
Yin L, et al. Gastro-floating Tablets of Cephalexin: Preparation and in Vitro/in Vivo Evaluation. Int J Pharm. 2013 Aug 16;452(1-2):241-8. PubMed PMID: 23680730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastro-floating tablets of cephalexin: preparation and in vitro/in vivo evaluation. AU - Yin,Lifang, AU - Qin,Chao, AU - Chen,Kaisheng, AU - Zhu,Chunli, AU - Cao,Hui, AU - Zhou,Jianping, AU - He,Wei, AU - Zhang,Qiang, Y1 - 2013/05/13/ PY - 2013/02/05/received PY - 2013/04/28/revised PY - 2013/05/03/accepted PY - 2013/5/18/entrez PY - 2013/5/18/pubmed PY - 2014/1/17/medline SP - 241 EP - 8 JF - International journal of pharmaceutics JO - Int J Pharm VL - 452 IS - 1-2 N2 - Gastro-floating tablets of cephalexin were developed to prolong the residence time in major absorption sites. Gastro-floating tablets were prepared and optimized using hydroxypropyl methylcellulose (HPMC K100M) as matrix and sodium bicarbonate as a gas-forming agent. The properties of the tablets in terms of floating lag time, floating time and in vitro release were evaluated. Furthermore, in vivo pharmacokinetic study in fed and fasted beagle dogs was performed. The gastro-floating tablets had short floating lag time and exhibited a satisfactory sustained-release profile in vitro. Compared with conventional capsules, the gastro-floating tablets presented a sustained-release behavior with a relative bioavailability of 99.4%, while the reference sustained-release tablets gave a relative bioavailability of only 39.3%. Meanwhile, the food had significant effect on the pharmacokinetics of sustained-release tablets. It was concluded that the gastro-floating tablets had a sustained-release effect in vitro and in vivo, as well as desired pharmacokinetic properties in both fed and fasted conditions. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/23680730/Gastro_floating_tablets_of_cephalexin:_preparation_and_in_vitro/in_vivo_evaluation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(13)00410-9 DB - PRIME DP - Unbound Medicine ER -