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Coffee consumption and the risk of overall and fatal prostate cancer in the NIH-AARP Diet and Health Study.

Abstract

PURPOSE

Evidence on the association between coffee consumption and prostate cancer risk is inconsistent; furthermore, few studies have examined the relationship between coffee consumption and fatal prostate cancer. The aim of this study was to investigate whether coffee intake is associated with the risk of overall and fatal prostate cancer.

METHODS

We conducted a prospective analysis among 288,391 men in the National Institutes of Health AARP Diet and Health Study who were between 50 and 71 years old at baseline in 1995-1996. Coffee consumption was assessed at baseline. Cox proportional hazards models were used to calculate the age- and multivariable-adjusted hazard ratios (HR)s and 95 % confidence intervals (CIs).

RESULTS

Over 11 years of follow-up, 23,335 cases of prostate cancer were ascertained, including 2,927 advanced and 917 fatal cases. Coffee consumption was not significantly associated with prostate cancer risk. The multivariable-adjusted HRs (95 % CI), comparing those who drank six or more cups per day to nondrinker, were as follows: 0.94 (0.86-1.02), p trend = 0.08 for overall prostate cancer, 1.13 (0.91-1.40), p trend = 0.62 for advanced prostate cancer, and 0.79 (0.53-1.17), p trend = 0.20 for fatal prostate cancer. The findings remained nonsignificant when we stratified by prostate-specific antigen testing history or restricted to nonsmokers.

CONCLUSIONS

We found no statistically significant association between coffee consumption and the risk of overall, advanced, or fatal prostate cancer in this cohort, though a modest reduction in risk could not be excluded.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA. bosirec@mail.harvard.edu

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    Source

    Cancer causes & control : CCC 24:8 2013 Aug pg 1527-34

    MeSH

    Aged
    Coffee
    Feeding Behavior
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    National Institutes of Health (U.S.)
    Prognosis
    Prospective Studies
    Prostatic Neoplasms
    Risk Factors
    Survival Rate
    United States

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23681472

    Citation

    Bosire, Claire, et al. "Coffee Consumption and the Risk of Overall and Fatal Prostate Cancer in the NIH-AARP Diet and Health Study." Cancer Causes & Control : CCC, vol. 24, no. 8, 2013, pp. 1527-34.
    Bosire C, Stampfer MJ, Subar AF, et al. Coffee consumption and the risk of overall and fatal prostate cancer in the NIH-AARP Diet and Health Study. Cancer Causes Control. 2013;24(8):1527-34.
    Bosire, C., Stampfer, M. J., Subar, A. F., Wilson, K. M., Park, Y., & Sinha, R. (2013). Coffee consumption and the risk of overall and fatal prostate cancer in the NIH-AARP Diet and Health Study. Cancer Causes & Control : CCC, 24(8), pp. 1527-34. doi:10.1007/s10552-013-0229-6.
    Bosire C, et al. Coffee Consumption and the Risk of Overall and Fatal Prostate Cancer in the NIH-AARP Diet and Health Study. Cancer Causes Control. 2013;24(8):1527-34. PubMed PMID: 23681472.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Coffee consumption and the risk of overall and fatal prostate cancer in the NIH-AARP Diet and Health Study. AU - Bosire,Claire, AU - Stampfer,Meir J, AU - Subar,Amy F, AU - Wilson,Kathryn M, AU - Park,Yikyung, AU - Sinha,Rashmi, Y1 - 2013/05/17/ PY - 2013/01/14/received PY - 2013/05/07/accepted PY - 2013/5/18/entrez PY - 2013/5/18/pubmed PY - 2014/3/14/medline SP - 1527 EP - 34 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 24 IS - 8 N2 - PURPOSE: Evidence on the association between coffee consumption and prostate cancer risk is inconsistent; furthermore, few studies have examined the relationship between coffee consumption and fatal prostate cancer. The aim of this study was to investigate whether coffee intake is associated with the risk of overall and fatal prostate cancer. METHODS: We conducted a prospective analysis among 288,391 men in the National Institutes of Health AARP Diet and Health Study who were between 50 and 71 years old at baseline in 1995-1996. Coffee consumption was assessed at baseline. Cox proportional hazards models were used to calculate the age- and multivariable-adjusted hazard ratios (HR)s and 95 % confidence intervals (CIs). RESULTS: Over 11 years of follow-up, 23,335 cases of prostate cancer were ascertained, including 2,927 advanced and 917 fatal cases. Coffee consumption was not significantly associated with prostate cancer risk. The multivariable-adjusted HRs (95 % CI), comparing those who drank six or more cups per day to nondrinker, were as follows: 0.94 (0.86-1.02), p trend = 0.08 for overall prostate cancer, 1.13 (0.91-1.40), p trend = 0.62 for advanced prostate cancer, and 0.79 (0.53-1.17), p trend = 0.20 for fatal prostate cancer. The findings remained nonsignificant when we stratified by prostate-specific antigen testing history or restricted to nonsmokers. CONCLUSIONS: We found no statistically significant association between coffee consumption and the risk of overall, advanced, or fatal prostate cancer in this cohort, though a modest reduction in risk could not be excluded. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/23681472/Coffee_consumption_and_the_risk_of_overall_and_fatal_prostate_cancer_in_the_NIH_AARP_Diet_and_Health_Study_ L2 - https://doi.org/10.1007/s10552-013-0229-6 DB - PRIME DP - Unbound Medicine ER -