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Choroidal thickness measurement in myopic eyes by enhanced depth optical coherence tomography.
Ophthalmology 2013; 120(9):1909-14O

Abstract

PURPOSE

To measure choroidal thickness (CT) in myopic eyes using enhanced depth imaging (EDI).

DESIGN

A cross-sectional study.

PARTICIPANTS

Fifty-six consecutive patients with spherical equivalent refractive error of at least 6 diopters (D) were evaluated.

METHODS

Enhanced depth imaging optical coherence tomography (OCT) images were obtained by positioning the spectral-domain OCT device close enough to the eye to acquire an enhanced signal of the choroidal layer. Choroidal depth was measured as the distance between the outer reflective retinal pigment epithelium (RPE) layer and the inner sclera border. Measurements were made in a horizontal fashion across the fovea at 500-μm intervals of the sections. The CT was measured at the subfoveal region in a horizontal fashion, 3 mm temporal to fovea and 3 mm nasal to fovea.

MAIN OUTCOME MEASURES

Correlations among CT with age, refractive error in diopters, and visual acuity in logarithm of the minimum angle of resolution (logMAR) were analyzed with linear mixed models.

RESULTS

The mean age of the 56 patients was 50.4 years (± 2.03 years standard deviation; interquartile range [IQR], 42-62 years), and the mean refractive error was -8.7 D (IQR, -6.1 to -11 D). The mean subfoveal CT was 118 μm (± 68 μm) and correlated negatively with age (P = 0.032) and refractive error (P = 0.011). Regression analysis suggested that subfoveal CT decreased by 11.9 μm for each decade of life and by 6.205 μm for each diopter of myopia. The subfoveal CT was inversely correlated with the logMAR visual acuity (P = 0.008), and visual acuity improved by 0.02 (logMAR) in a 10-μm increase in CT.

CONCLUSIONS

Choroidal thickness decreases with age and severity of myopia. Visual acuity decreases in line with decreasing subfoveal CT. A reduction in CT is related to aging and the severity of myopia, whereas visual acuity depends on subfoveal CT. Our study supports the theory that choroidal abnormality may play a key role in the pathogenesis of myopic degeneration.

FINANCIAL DISCLOSURE(S)

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Authors+Show Affiliations

Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23683921

Citation

Ho, Mary, et al. "Choroidal Thickness Measurement in Myopic Eyes By Enhanced Depth Optical Coherence Tomography." Ophthalmology, vol. 120, no. 9, 2013, pp. 1909-14.
Ho M, Liu DT, Chan VC, et al. Choroidal thickness measurement in myopic eyes by enhanced depth optical coherence tomography. Ophthalmology. 2013;120(9):1909-14.
Ho, M., Liu, D. T., Chan, V. C., & Lam, D. S. (2013). Choroidal thickness measurement in myopic eyes by enhanced depth optical coherence tomography. Ophthalmology, 120(9), pp. 1909-14. doi:10.1016/j.ophtha.2013.02.005.
Ho M, et al. Choroidal Thickness Measurement in Myopic Eyes By Enhanced Depth Optical Coherence Tomography. Ophthalmology. 2013;120(9):1909-14. PubMed PMID: 23683921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Choroidal thickness measurement in myopic eyes by enhanced depth optical coherence tomography. AU - Ho,Mary, AU - Liu,David T L, AU - Chan,Vesta C K, AU - Lam,Dennis S C, Y1 - 2013/05/15/ PY - 2012/07/28/received PY - 2013/02/05/revised PY - 2013/02/06/accepted PY - 2013/5/21/entrez PY - 2013/5/21/pubmed PY - 2013/11/20/medline SP - 1909 EP - 14 JF - Ophthalmology JO - Ophthalmology VL - 120 IS - 9 N2 - PURPOSE: To measure choroidal thickness (CT) in myopic eyes using enhanced depth imaging (EDI). DESIGN: A cross-sectional study. PARTICIPANTS: Fifty-six consecutive patients with spherical equivalent refractive error of at least 6 diopters (D) were evaluated. METHODS: Enhanced depth imaging optical coherence tomography (OCT) images were obtained by positioning the spectral-domain OCT device close enough to the eye to acquire an enhanced signal of the choroidal layer. Choroidal depth was measured as the distance between the outer reflective retinal pigment epithelium (RPE) layer and the inner sclera border. Measurements were made in a horizontal fashion across the fovea at 500-μm intervals of the sections. The CT was measured at the subfoveal region in a horizontal fashion, 3 mm temporal to fovea and 3 mm nasal to fovea. MAIN OUTCOME MEASURES: Correlations among CT with age, refractive error in diopters, and visual acuity in logarithm of the minimum angle of resolution (logMAR) were analyzed with linear mixed models. RESULTS: The mean age of the 56 patients was 50.4 years (± 2.03 years standard deviation; interquartile range [IQR], 42-62 years), and the mean refractive error was -8.7 D (IQR, -6.1 to -11 D). The mean subfoveal CT was 118 μm (± 68 μm) and correlated negatively with age (P = 0.032) and refractive error (P = 0.011). Regression analysis suggested that subfoveal CT decreased by 11.9 μm for each decade of life and by 6.205 μm for each diopter of myopia. The subfoveal CT was inversely correlated with the logMAR visual acuity (P = 0.008), and visual acuity improved by 0.02 (logMAR) in a 10-μm increase in CT. CONCLUSIONS: Choroidal thickness decreases with age and severity of myopia. Visual acuity decreases in line with decreasing subfoveal CT. A reduction in CT is related to aging and the severity of myopia, whereas visual acuity depends on subfoveal CT. Our study supports the theory that choroidal abnormality may play a key role in the pathogenesis of myopic degeneration. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/23683921/Choroidal_thickness_measurement_in_myopic_eyes_by_enhanced_depth_optical_coherence_tomography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(13)00124-3 DB - PRIME DP - Unbound Medicine ER -