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Use of low-dose gabapentin for aggressive behavior in vascular and Mixed Vascular/Alzheimer Dementia.
J Neuropsychiatry Clin Neurosci. 2013 Spring; 25(2):120-5.JN

Abstract

Recent reports highlighting serious adverse effects of antipsychotic medication in behavioral and psychological symptoms of dementia (BPSD) has led to calls for research on alternative agents. The authors describe the use of low-dose gabapentin to treat seven patients with a diagnosis of ICD-10 vascular or Mixed Vascular/Alzheimer Dementia with serious aggressive behavior. All seven patients had impressive and clinically significant responses to treatment. Treatment was tolerated in each case without adverse reactions. Our findings suggest that gabapentin should be considered for treating aggressive behavior in patients with vascular or mixed dementia and that it is well tolerated in this context.

Authors+Show Affiliations

Dept. of Old Age Psychiatry, St Vincent's University Hospital, Dublin, Ireland. c.cooney@st-vincents.ieNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23686029

Citation

Cooney, Colm, et al. "Use of Low-dose Gabapentin for Aggressive Behavior in Vascular and Mixed Vascular/Alzheimer Dementia." The Journal of Neuropsychiatry and Clinical Neurosciences, vol. 25, no. 2, 2013, pp. 120-5.
Cooney C, Murphy S, Tessema H, et al. Use of low-dose gabapentin for aggressive behavior in vascular and Mixed Vascular/Alzheimer Dementia. J Neuropsychiatry Clin Neurosci. 2013;25(2):120-5.
Cooney, C., Murphy, S., Tessema, H., & Freyne, A. (2013). Use of low-dose gabapentin for aggressive behavior in vascular and Mixed Vascular/Alzheimer Dementia. The Journal of Neuropsychiatry and Clinical Neurosciences, 25(2), 120-5. https://doi.org/10.1176/appi.neuropsych.12050115
Cooney C, et al. Use of Low-dose Gabapentin for Aggressive Behavior in Vascular and Mixed Vascular/Alzheimer Dementia. J Neuropsychiatry Clin Neurosci. 2013;25(2):120-5. PubMed PMID: 23686029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of low-dose gabapentin for aggressive behavior in vascular and Mixed Vascular/Alzheimer Dementia. AU - Cooney,Colm, AU - Murphy,Sinead, AU - Tessema,Hiberet, AU - Freyne,Aideen, PY - 2013/5/21/entrez PY - 2013/5/21/pubmed PY - 2014/1/5/medline SP - 120 EP - 5 JF - The Journal of neuropsychiatry and clinical neurosciences JO - J Neuropsychiatry Clin Neurosci VL - 25 IS - 2 N2 - Recent reports highlighting serious adverse effects of antipsychotic medication in behavioral and psychological symptoms of dementia (BPSD) has led to calls for research on alternative agents. The authors describe the use of low-dose gabapentin to treat seven patients with a diagnosis of ICD-10 vascular or Mixed Vascular/Alzheimer Dementia with serious aggressive behavior. All seven patients had impressive and clinically significant responses to treatment. Treatment was tolerated in each case without adverse reactions. Our findings suggest that gabapentin should be considered for treating aggressive behavior in patients with vascular or mixed dementia and that it is well tolerated in this context. SN - 1545-7222 UR - https://www.unboundmedicine.com/medline/citation/23686029/Use_of_low_dose_gabapentin_for_aggressive_behavior_in_vascular_and_Mixed_Vascular/Alzheimer_Dementia_ L2 - https://neuro.psychiatryonline.org/doi/10.1176/appi.neuropsych.12050115?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -