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24-hour efficacy of the bimatoprost-timolol fixed combination versus latanoprost as first choice therapy in subjects with high-pressure exfoliation syndrome and glaucoma.
Br J Ophthalmol. 2013 Jul; 97(7):857-61.BJ

Abstract

AIM

To compare the 24-h intraocular pressure (IOP) control obtained with the bimatoprost-timolol fixed combination (BTFC) versus latanoprost in newly diagnosed, previously untreated exfoliation syndrome (XFS) or exfoliative glaucoma (XFG) patients with baseline morning IOP greater than 29 mm Hg.

METHODS

One eye of 41 XFS/XFG patients who met inclusion criteria was included in this prospective, observer-masked, crossover, comparison protocol. All subjects underwent a 24-h untreated curve and were then randomised to either evening administered BTFC or latanoprost for 3 months and then switched to the opposite therapy. At the end of each treatment period, patients underwent a treated 24-h IOP assessment.

RESULTS

37 patients completed the trial. At baseline, mean untreated 24-h IOP was 31.1 mm Hg. Mean 24-h IOP with BTFC was significantly lower than with latanoprost (18.9 vs 21.2 mm Hg; p<0.001). Furthermore, BTFC reduced IOP significantly more than latanoprost at every time point, for the mean peak and trough 24-h IOP (p<0.001). There was no difference, however, in mean 24-h IOP fluctuation between the two medications (3.8 with BTFC vs 4.2 with latanoprost; p=0.161). Both treatments were well tolerated and there was no statistically significant difference for any adverse event between them.

CONCLUSIONS

As first choice therapy in high-pressure, at-risk exfoliation patients, BTFC controlled mean 24-h IOP significantly better than latanoprost monotherapy.

Authors+Show Affiliations

Glaucoma Unit, 1st University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23686322

Citation

Konstas, Anastasios-Georgios P., et al. "24-hour Efficacy of the Bimatoprost-timolol Fixed Combination Versus Latanoprost as First Choice Therapy in Subjects With High-pressure Exfoliation Syndrome and Glaucoma." The British Journal of Ophthalmology, vol. 97, no. 7, 2013, pp. 857-61.
Konstas AG, Holló G, Mikropoulos DG, et al. 24-hour efficacy of the bimatoprost-timolol fixed combination versus latanoprost as first choice therapy in subjects with high-pressure exfoliation syndrome and glaucoma. Br J Ophthalmol. 2013;97(7):857-61.
Konstas, A. G., Holló, G., Mikropoulos, D. G., Haidich, A. B., Dimopoulos, A. T., Empeslidis, T., Teus, M. A., & Ritch, R. (2013). 24-hour efficacy of the bimatoprost-timolol fixed combination versus latanoprost as first choice therapy in subjects with high-pressure exfoliation syndrome and glaucoma. The British Journal of Ophthalmology, 97(7), 857-61. https://doi.org/10.1136/bjophthalmol-2012-302843
Konstas AG, et al. 24-hour Efficacy of the Bimatoprost-timolol Fixed Combination Versus Latanoprost as First Choice Therapy in Subjects With High-pressure Exfoliation Syndrome and Glaucoma. Br J Ophthalmol. 2013;97(7):857-61. PubMed PMID: 23686322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 24-hour efficacy of the bimatoprost-timolol fixed combination versus latanoprost as first choice therapy in subjects with high-pressure exfoliation syndrome and glaucoma. AU - Konstas,Anastasios-Georgios P, AU - Holló,Gábor, AU - Mikropoulos,Dimitrios G, AU - Haidich,Anna-Bettina, AU - Dimopoulos,Antonios T, AU - Empeslidis,Theodoros, AU - Teus,Miguel A, AU - Ritch,Robert, Y1 - 2013/05/18/ PY - 2013/5/21/entrez PY - 2013/5/21/pubmed PY - 2013/8/24/medline KW - Glaucoma KW - Intraocular pressure KW - Treatment Medical SP - 857 EP - 61 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 97 IS - 7 N2 - AIM: To compare the 24-h intraocular pressure (IOP) control obtained with the bimatoprost-timolol fixed combination (BTFC) versus latanoprost in newly diagnosed, previously untreated exfoliation syndrome (XFS) or exfoliative glaucoma (XFG) patients with baseline morning IOP greater than 29 mm Hg. METHODS: One eye of 41 XFS/XFG patients who met inclusion criteria was included in this prospective, observer-masked, crossover, comparison protocol. All subjects underwent a 24-h untreated curve and were then randomised to either evening administered BTFC or latanoprost for 3 months and then switched to the opposite therapy. At the end of each treatment period, patients underwent a treated 24-h IOP assessment. RESULTS: 37 patients completed the trial. At baseline, mean untreated 24-h IOP was 31.1 mm Hg. Mean 24-h IOP with BTFC was significantly lower than with latanoprost (18.9 vs 21.2 mm Hg; p<0.001). Furthermore, BTFC reduced IOP significantly more than latanoprost at every time point, for the mean peak and trough 24-h IOP (p<0.001). There was no difference, however, in mean 24-h IOP fluctuation between the two medications (3.8 with BTFC vs 4.2 with latanoprost; p=0.161). Both treatments were well tolerated and there was no statistically significant difference for any adverse event between them. CONCLUSIONS: As first choice therapy in high-pressure, at-risk exfoliation patients, BTFC controlled mean 24-h IOP significantly better than latanoprost monotherapy. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/23686322/24_hour_efficacy_of_the_bimatoprost_timolol_fixed_combination_versus_latanoprost_as_first_choice_therapy_in_subjects_with_high_pressure_exfoliation_syndrome_and_glaucoma_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&amp;pmid=23686322 DB - PRIME DP - Unbound Medicine ER -