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Comparison of normal fasting and one-hour glucose levels as predictors of future diabetes during a 34-year follow-up.
Ann Med 2013; 45(4):336-40AM

Abstract

INTRODUCTION

Early identification of those at risk of developing type 2 diabetes (T2DM) is essential. We examined how normoglycemic levels of fasting blood glucose (FBG) and 1-hour glucose predict the development of diabetes among men initially at low risk.

METHODS

In the Helsinki Businessmen Study (men born in 1919- 1934), 1,145 men had normal FBG (< 5.0 mmol/L) in 1974, and 1-hour glucose values available. Multivariate, adjusted models were used to investigate how fasting and 1-hour glucose at baseline related to new-onset diabetes during a follow-up of 34 years.

RESULTS

The median FBG and 1-hour glucose values at baseline were 4.4 and 6.6 mmol/L, respectively. During follow-up, 108 men developed diabetes. The risk of incident diabetes was doubled for the highest quintile of FBG (fully adjusted relative risk (RR) 2.22, 95% confidence interval (CI) 1.10-4.50), and quadrupled for that of 1-hour glucose (RR 4.23, 95% CI 2.49-7.17). FBG could not separate the risk for those with higher levels of glucose in the range < 5.0 mmol/L, whereas 1-hour glucose discriminated the risk better at higher values.

CONCLUSIONS

Higher values in the normoglycemic range for both fasting and 1-hour glucose predicted long-term incidence of diabetes in healthy middle-aged men.

Authors+Show Affiliations

Department of Medicine, Geriatric Clinic, University of Helsinki, Helsinki, Finland. arto.strandberg@kolumbus.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23688029

Citation

Strandberg, Arto Y., et al. "Comparison of Normal Fasting and One-hour Glucose Levels as Predictors of Future Diabetes During a 34-year Follow-up." Annals of Medicine, vol. 45, no. 4, 2013, pp. 336-40.
Strandberg AY, Pienimäki T, Pitkälä KH, et al. Comparison of normal fasting and one-hour glucose levels as predictors of future diabetes during a 34-year follow-up. Ann Med. 2013;45(4):336-40.
Strandberg, A. Y., Pienimäki, T., Pitkälä, K. H., Tilvis, R. S., Salomaa, V. V., & Strandberg, T. E. (2013). Comparison of normal fasting and one-hour glucose levels as predictors of future diabetes during a 34-year follow-up. Annals of Medicine, 45(4), pp. 336-40. doi:10.3109/07853890.2013.785233.
Strandberg AY, et al. Comparison of Normal Fasting and One-hour Glucose Levels as Predictors of Future Diabetes During a 34-year Follow-up. Ann Med. 2013;45(4):336-40. PubMed PMID: 23688029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of normal fasting and one-hour glucose levels as predictors of future diabetes during a 34-year follow-up. AU - Strandberg,Arto Y, AU - Pienimäki,Tuula, AU - Pitkälä,Kaisu H, AU - Tilvis,Reijo S, AU - Salomaa,Veikko V, AU - Strandberg,Timo E, Y1 - 2013/05/20/ PY - 2013/5/22/entrez PY - 2013/5/22/pubmed PY - 2013/11/12/medline SP - 336 EP - 40 JF - Annals of medicine JO - Ann. Med. VL - 45 IS - 4 N2 - INTRODUCTION: Early identification of those at risk of developing type 2 diabetes (T2DM) is essential. We examined how normoglycemic levels of fasting blood glucose (FBG) and 1-hour glucose predict the development of diabetes among men initially at low risk. METHODS: In the Helsinki Businessmen Study (men born in 1919- 1934), 1,145 men had normal FBG (< 5.0 mmol/L) in 1974, and 1-hour glucose values available. Multivariate, adjusted models were used to investigate how fasting and 1-hour glucose at baseline related to new-onset diabetes during a follow-up of 34 years. RESULTS: The median FBG and 1-hour glucose values at baseline were 4.4 and 6.6 mmol/L, respectively. During follow-up, 108 men developed diabetes. The risk of incident diabetes was doubled for the highest quintile of FBG (fully adjusted relative risk (RR) 2.22, 95% confidence interval (CI) 1.10-4.50), and quadrupled for that of 1-hour glucose (RR 4.23, 95% CI 2.49-7.17). FBG could not separate the risk for those with higher levels of glucose in the range < 5.0 mmol/L, whereas 1-hour glucose discriminated the risk better at higher values. CONCLUSIONS: Higher values in the normoglycemic range for both fasting and 1-hour glucose predicted long-term incidence of diabetes in healthy middle-aged men. SN - 1365-2060 UR - https://www.unboundmedicine.com/medline/citation/23688029/Comparison_of_normal_fasting_and_one_hour_glucose_levels_as_predictors_of_future_diabetes_during_a_34_year_follow_up_ L2 - http://www.tandfonline.com/doi/full/10.3109/07853890.2013.785233 DB - PRIME DP - Unbound Medicine ER -