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Toward tunable amphiphilic copolymers via CuAAC click chemistry of oligocaprolactones onto starch backbone.
Carbohydr Polym 2013; 96(1):259-69CP

Abstract

Starch-based tunable amphiphilic copolymers are easily obtained by grafting polycaprolactone chains via 1,3 dipolar Copper-Catalyzed Azide-Alkyne Cycloaddition (click chemistry CuAAC), starting from propargylated starch and azido oligocaprolactones with different chain lengths as the precursors. The copolymers are characterized by (1)H and (13)C NMR, from which a degree of substitution of starch can tentatively be deduced. Besides these bulk characterizations, the surface of the functionalized starch is also characterized by XPS which confirms the triazole formation, particularly through the deconvolution of the N 1s peak, and by ToF-SIMS which, not only confirms the surface modification, but also highlights the disappearance of the Cu(+) cations. The solubility and swelling behaviours of these copolymers have been investigated, which clearly show the dependence both on the solvent and the PCL chain length. These investigations highlight the swelling dependence on the δd component of the Hansen solubility parameter of solvents. Finally, at low concentration, they present the capacity to organize themselves in aggregates in aqueous solutions, as seen from TEM and DLS investigations.

Authors+Show Affiliations

Université de Lyon, Université Claude Bernard Lyon 1, IMP@Lyon1, UMR CNRS 5223, Polytech Lyon, 15 bd Latarjet, 69622 Villeurbanne, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23688479

Citation

Uliniuc, Ancuta, et al. "Toward Tunable Amphiphilic Copolymers Via CuAAC Click Chemistry of Oligocaprolactones Onto Starch Backbone." Carbohydrate Polymers, vol. 96, no. 1, 2013, pp. 259-69.
Uliniuc A, Popa M, Drockenmuller E, et al. Toward tunable amphiphilic copolymers via CuAAC click chemistry of oligocaprolactones onto starch backbone. Carbohydr Polym. 2013;96(1):259-69.
Uliniuc, A., Popa, M., Drockenmuller, E., Boisson, F., Leonard, D., & Hamaide, T. (2013). Toward tunable amphiphilic copolymers via CuAAC click chemistry of oligocaprolactones onto starch backbone. Carbohydrate Polymers, 96(1), pp. 259-69. doi:10.1016/j.carbpol.2013.03.047.
Uliniuc A, et al. Toward Tunable Amphiphilic Copolymers Via CuAAC Click Chemistry of Oligocaprolactones Onto Starch Backbone. Carbohydr Polym. 2013 Jul 1;96(1):259-69. PubMed PMID: 23688479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toward tunable amphiphilic copolymers via CuAAC click chemistry of oligocaprolactones onto starch backbone. AU - Uliniuc,Ancuta, AU - Popa,Marcel, AU - Drockenmuller,Eric, AU - Boisson,Fernande, AU - Leonard,Didier, AU - Hamaide,Thierry, Y1 - 2013/03/21/ PY - 2012/12/26/received PY - 2013/03/11/revised PY - 2013/03/14/accepted PY - 2013/5/22/entrez PY - 2013/5/22/pubmed PY - 2013/12/24/medline SP - 259 EP - 69 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 96 IS - 1 N2 - Starch-based tunable amphiphilic copolymers are easily obtained by grafting polycaprolactone chains via 1,3 dipolar Copper-Catalyzed Azide-Alkyne Cycloaddition (click chemistry CuAAC), starting from propargylated starch and azido oligocaprolactones with different chain lengths as the precursors. The copolymers are characterized by (1)H and (13)C NMR, from which a degree of substitution of starch can tentatively be deduced. Besides these bulk characterizations, the surface of the functionalized starch is also characterized by XPS which confirms the triazole formation, particularly through the deconvolution of the N 1s peak, and by ToF-SIMS which, not only confirms the surface modification, but also highlights the disappearance of the Cu(+) cations. The solubility and swelling behaviours of these copolymers have been investigated, which clearly show the dependence both on the solvent and the PCL chain length. These investigations highlight the swelling dependence on the δd component of the Hansen solubility parameter of solvents. Finally, at low concentration, they present the capacity to organize themselves in aggregates in aqueous solutions, as seen from TEM and DLS investigations. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/23688479/Toward_tunable_amphiphilic_copolymers_via_CuAAC_click_chemistry_of_oligocaprolactones_onto_starch_backbone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(13)00297-X DB - PRIME DP - Unbound Medicine ER -