Tags

Type your tag names separated by a space and hit enter

Apolipoprotein E polymorphisms in frontotemporal lobar degeneration: a meta-analysis.
Alzheimers Dement. 2013 Nov; 9(6):706-13.AD

Abstract

OBJECTIVE

Case-control studies have not been consistent in showing association between apolipoprotein E (APOE) polymorphisms and frontotemporal lobar degeneration (FTLD), producing contradictory findings. The study objective was to define and quantify further the disease risk associated with the carriage of different APOE alleles to determine whether APOE gene polymorphism is a risk factor for FTLD.

METHODS

A systematic review of all case-control studies investigating the association between the APOE gene and FTLD up to December 2011 was conducted. Case-control studies using clinical or pathological criteria for FTLD and reporting APOE allelic or genotypic data were included. Pooled odds ratios (ORs) were estimated using a random effects model, and 95% confidence intervals (CIs) were calculated.

RESULTS

Twenty-eight case-control studies met the inclusion criteria. Carriage of the ε2 allele had no effect on disease risk. On the contrary, carriage of the ε4 allele was associated with a significantly increased disease risk (ε4 carriers vs non-ε4 carriers: OR, 1.94; 95% CI, 1.43-2.64; ε4 vs ε3 allele: OR, 1.83; 95% CI, 1.34-2.52). Furthermore, a gene-dosage effect for the ε4 allele was found. There was no evidence of publication bias, but heterogeneity between the studies was high.

CONCLUSIONS

Our study provides evidence for an association between the APOE ε4 allele and frontotemporal lobar degeneration.

Authors+Show Affiliations

Neurology II, Department of Neuroscience, University of Torino, Torino, Italy. Electronic address: elisa.rubino@unito.it.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

23688578

Citation

Rubino, Elisa, et al. "Apolipoprotein E Polymorphisms in Frontotemporal Lobar Degeneration: a Meta-analysis." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 9, no. 6, 2013, pp. 706-13.
Rubino E, Vacca A, Govone F, et al. Apolipoprotein E polymorphisms in frontotemporal lobar degeneration: a meta-analysis. Alzheimers Dement. 2013;9(6):706-13.
Rubino, E., Vacca, A., Govone, F., De Martino, P., Pinessi, L., & Rainero, I. (2013). Apolipoprotein E polymorphisms in frontotemporal lobar degeneration: a meta-analysis. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 9(6), 706-13. https://doi.org/10.1016/j.jalz.2012.10.013
Rubino E, et al. Apolipoprotein E Polymorphisms in Frontotemporal Lobar Degeneration: a Meta-analysis. Alzheimers Dement. 2013;9(6):706-13. PubMed PMID: 23688578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E polymorphisms in frontotemporal lobar degeneration: a meta-analysis. AU - Rubino,Elisa, AU - Vacca,Alessandro, AU - Govone,Flora, AU - De Martino,Paola, AU - Pinessi,Lorenzo, AU - Rainero,Innocenzo, Y1 - 2013/05/18/ PY - 2012/04/10/received PY - 2012/10/05/revised PY - 2012/10/22/accepted PY - 2013/5/22/entrez PY - 2013/5/22/pubmed PY - 2014/6/21/medline KW - APOE KW - Case–control study KW - Frontotemporal lobar degeneration KW - Meta-analysis KW - Polymorphism SP - 706 EP - 13 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 9 IS - 6 N2 - OBJECTIVE: Case-control studies have not been consistent in showing association between apolipoprotein E (APOE) polymorphisms and frontotemporal lobar degeneration (FTLD), producing contradictory findings. The study objective was to define and quantify further the disease risk associated with the carriage of different APOE alleles to determine whether APOE gene polymorphism is a risk factor for FTLD. METHODS: A systematic review of all case-control studies investigating the association between the APOE gene and FTLD up to December 2011 was conducted. Case-control studies using clinical or pathological criteria for FTLD and reporting APOE allelic or genotypic data were included. Pooled odds ratios (ORs) were estimated using a random effects model, and 95% confidence intervals (CIs) were calculated. RESULTS: Twenty-eight case-control studies met the inclusion criteria. Carriage of the ε2 allele had no effect on disease risk. On the contrary, carriage of the ε4 allele was associated with a significantly increased disease risk (ε4 carriers vs non-ε4 carriers: OR, 1.94; 95% CI, 1.43-2.64; ε4 vs ε3 allele: OR, 1.83; 95% CI, 1.34-2.52). Furthermore, a gene-dosage effect for the ε4 allele was found. There was no evidence of publication bias, but heterogeneity between the studies was high. CONCLUSIONS: Our study provides evidence for an association between the APOE ε4 allele and frontotemporal lobar degeneration. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/23688578/Apolipoprotein_E_polymorphisms_in_frontotemporal_lobar_degeneration:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(12)02579-4 DB - PRIME DP - Unbound Medicine ER -