Tags

Type your tag names separated by a space and hit enter

The role of Beta-adrenergic receptor blockers in Alzheimer's disease: potential genetic and cellular signaling mechanisms.
Am J Alzheimers Dis Other Demen. 2013 Aug; 28(5):427-39.AJ

Abstract

According to genetic studies, Alzheimer's disease (AD) is linked to beta-adrenergic receptor blockade through numerous factors, including human leukocyte antigen genes, the renin-angiotensin system, poly(adenosine diphosphate-ribose) polymerase 1, nerve growth factor, vascular endothelial growth factor, and the reduced form of nicotinamide adenine dinucleotide phosphate. Beta-adrenergic receptor blockade is also implicated in AD due to its effects on matrix metalloproteinases, mitogen-activated protein kinase pathways, prostaglandins, cyclooxygenase-2, and nitric oxide synthase. Beta-adrenergic receptor blockade may also have a significant role in AD, although the role is controversial. Behavioral symptoms, sex, or genetic factors, including Beta 2-adrenergic receptor variants, apolipoprotein E, and cytochrome P450 CYP2D6, may contribute to beta-adrenergic receptor blockade modulation in AD. Thus, the characterization of beta-adrenergic receptor blockade in patients with AD is needed.

Authors+Show Affiliations

Vietnamese American Medical Research Foundation, Westminster, California, CA 92683, USA. Lng2687765@aol.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23689075

Citation

Lương, Khanh vinh quoc, and Lan Thi Hoàng Nguyen. "The Role of Beta-adrenergic Receptor Blockers in Alzheimer's Disease: Potential Genetic and Cellular Signaling Mechanisms." American Journal of Alzheimer's Disease and Other Dementias, vol. 28, no. 5, 2013, pp. 427-39.
Lương Kv, Nguyen LT. The role of Beta-adrenergic receptor blockers in Alzheimer's disease: potential genetic and cellular signaling mechanisms. Am J Alzheimers Dis Other Demen. 2013;28(5):427-39.
Lương, K. v., & Nguyen, L. T. (2013). The role of Beta-adrenergic receptor blockers in Alzheimer's disease: potential genetic and cellular signaling mechanisms. American Journal of Alzheimer's Disease and Other Dementias, 28(5), 427-39. https://doi.org/10.1177/1533317513488924
Lương Kv, Nguyen LT. The Role of Beta-adrenergic Receptor Blockers in Alzheimer's Disease: Potential Genetic and Cellular Signaling Mechanisms. Am J Alzheimers Dis Other Demen. 2013;28(5):427-39. PubMed PMID: 23689075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of Beta-adrenergic receptor blockers in Alzheimer's disease: potential genetic and cellular signaling mechanisms. AU - Lương,Khanh vinh quoc, AU - Nguyen,Lan Thi Hoàng, Y1 - 2013/05/20/ PY - 2013/5/22/entrez PY - 2013/5/22/pubmed PY - 2014/4/24/medline KW - Alzheimer’s disease KW - beta-adrenergic receptor antagonism KW - beta-adrenergic receptor blocker KW - dementia SP - 427 EP - 39 JF - American journal of Alzheimer's disease and other dementias JO - Am J Alzheimers Dis Other Demen VL - 28 IS - 5 N2 - According to genetic studies, Alzheimer's disease (AD) is linked to beta-adrenergic receptor blockade through numerous factors, including human leukocyte antigen genes, the renin-angiotensin system, poly(adenosine diphosphate-ribose) polymerase 1, nerve growth factor, vascular endothelial growth factor, and the reduced form of nicotinamide adenine dinucleotide phosphate. Beta-adrenergic receptor blockade is also implicated in AD due to its effects on matrix metalloproteinases, mitogen-activated protein kinase pathways, prostaglandins, cyclooxygenase-2, and nitric oxide synthase. Beta-adrenergic receptor blockade may also have a significant role in AD, although the role is controversial. Behavioral symptoms, sex, or genetic factors, including Beta 2-adrenergic receptor variants, apolipoprotein E, and cytochrome P450 CYP2D6, may contribute to beta-adrenergic receptor blockade modulation in AD. Thus, the characterization of beta-adrenergic receptor blockade in patients with AD is needed. SN - 1938-2731 UR - https://www.unboundmedicine.com/medline/citation/23689075/The_role_of_Beta_adrenergic_receptor_blockers_in_Alzheimer's_disease:_potential_genetic_and_cellular_signaling_mechanisms_ L2 - https://journals.sagepub.com/doi/10.1177/1533317513488924?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -