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The cycle characteristics of clomiphene with clomiphene and menotropins in polycystic ovary syndrome and non polycystic ovary syndrome infertile patients.
Minerva Ginecol. 2013 Jun; 65(3):311-7.MG

Abstract

AIM

This study compares the cycle characteristics of clomiphene (CC) with CC+HMG (Human Menopausal Gonadotropin or Menotropins) in Polycystic Ovary Syndrome (PCOS) and non-PCOS infertile patients.

METHODS

Patients were treated by CC + minimal HMg protocol. The cancellation rate, the mean number of different follicle sizes and endometrial thickness and pattern were compared.

RESULTS

The cancelled cycles due to non-responsiveness were significantly higher in CC compared to CC+ minimal HMg protocol. PCOS patients are significantly nonresponsive in CC cycle and hyperresponsive in CC+ minimal HMg cycles. The mean number of different sizes of follicles and the endometrial thickness were significantly higher in CC+ minimal HMg. PCOS patients were significantly different from non-PCOS regarding the number of mature follicle and endometrial thickness. The pregnancy rate was 11% (10.2% in non-PCOS and 12.2% in PCOS).

CONCLUSION

CC+ minimal HMg is a viable alternative to HMg /FSH only protocol in CC failure or resistant patients, and its efficacy can be mostly attributed to improvement of endometrial quality and increase in follicle number. Moreover, due to high cancellation of PCOS patients treated by this protocol, seemingly other alternatives should be found; perhaps sequential letrozole+HMg/FSH that have been shown to improve the ovarian response in this group of patients.

Links

Publisher Full Text

Authors+Show Affiliations

Ghasemi M
Department of Gynecology and Obstetrics, Faculty of Medicine, Zahedan University of Medical Sciences Zahedan, Iran.
Ashraf H
No affiliation info available
Koushyar H
No affiliation info available
Mousavifar N
No affiliation info available

MeSH

AdultCase-Control StudiesClomipheneDrug ResistanceEndometriumFemaleFertility Agents, FemaleHumansInfertility, FemaleMenotropinsOvarian FolliclePolycystic Ovary SyndromePregnancyPregnancy RateProspective StudiesTreatment FailureTreatment OutcomeYoung Adult

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23689174

Citation

Ghasemi, M, et al. "The Cycle Characteristics of Clomiphene With Clomiphene and Menotropins in Polycystic Ovary Syndrome and Non Polycystic Ovary Syndrome Infertile Patients." Minerva Ginecologica, vol. 65, no. 3, 2013, pp. 311-7.
Ghasemi M, Ashraf H, Koushyar H, et al. The cycle characteristics of clomiphene with clomiphene and menotropins in polycystic ovary syndrome and non polycystic ovary syndrome infertile patients. Minerva Ginecol. 2013;65(3):311-7.
Ghasemi, M., Ashraf, H., Koushyar, H., & Mousavifar, N. (2013). The cycle characteristics of clomiphene with clomiphene and menotropins in polycystic ovary syndrome and non polycystic ovary syndrome infertile patients. Minerva Ginecologica, 65(3), 311-7.
Ghasemi M, et al. The Cycle Characteristics of Clomiphene With Clomiphene and Menotropins in Polycystic Ovary Syndrome and Non Polycystic Ovary Syndrome Infertile Patients. Minerva Ginecol. 2013;65(3):311-7. PubMed PMID: 23689174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cycle characteristics of clomiphene with clomiphene and menotropins in polycystic ovary syndrome and non polycystic ovary syndrome infertile patients. AU - Ghasemi,M, AU - Ashraf,H, AU - Koushyar,H, AU - Mousavifar,N, PY - 2013/5/22/entrez PY - 2013/5/22/pubmed PY - 2013/9/18/medline SP - 311 EP - 7 JF - Minerva ginecologica JO - Minerva Ginecol VL - 65 IS - 3 N2 - AIM: This study compares the cycle characteristics of clomiphene (CC) with CC+HMG (Human Menopausal Gonadotropin or Menotropins) in Polycystic Ovary Syndrome (PCOS) and non-PCOS infertile patients. METHODS: Patients were treated by CC + minimal HMg protocol. The cancellation rate, the mean number of different follicle sizes and endometrial thickness and pattern were compared. RESULTS: The cancelled cycles due to non-responsiveness were significantly higher in CC compared to CC+ minimal HMg protocol. PCOS patients are significantly nonresponsive in CC cycle and hyperresponsive in CC+ minimal HMg cycles. The mean number of different sizes of follicles and the endometrial thickness were significantly higher in CC+ minimal HMg. PCOS patients were significantly different from non-PCOS regarding the number of mature follicle and endometrial thickness. The pregnancy rate was 11% (10.2% in non-PCOS and 12.2% in PCOS). CONCLUSION: CC+ minimal HMg is a viable alternative to HMg /FSH only protocol in CC failure or resistant patients, and its efficacy can be mostly attributed to improvement of endometrial quality and increase in follicle number. Moreover, due to high cancellation of PCOS patients treated by this protocol, seemingly other alternatives should be found; perhaps sequential letrozole+HMg/FSH that have been shown to improve the ovarian response in this group of patients. SN - 0026-4784 UR - https://www.unboundmedicine.com/medline/citation/23689174/The_cycle_characteristics_of_clomiphene_with_clomiphene_and_menotropins_in_polycystic_ovary_syndrome_and_non_polycystic_ovary_syndrome_infertile_patients_ L2 - http://www.minervamedica.it/index2.t?show=R09Y2013N03A0311 DB - PRIME DP - Unbound Medicine ER -