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Morphological parameters of lobular in situ neoplasia in stereotactic 11-gauge vacuum-assisted needle core biopsy do not predict the presence of malignancy on subsequent surgical excision.
Histopathology. 2013 Jul; 63(1):83-95.H

Abstract

AIMS

The management of lobular in situ neoplasia (LN) when diagnosed on core biopsy remains a controversial issue. The present study aimed to investigate the association between morphological parameters of LN on vacuum-assisted needle core biopsy (VANCB) and the presence of malignancy (ductal carcinoma in situ, pleomorphic lobular carcinoma in situ, or invasive carcinoma) at surgical excision (SE).

METHODS AND RESULTS

The study included 14 pathology departments in Italy. Available slides from 859 cases of VANCB reporting an original diagnosis of flat epithelial atypia, atypical ductal hyperplasia or LN, all with subsequent surgical excision, were reviewed. Overall, 286 cases of LN, pure or associated with other lesions, were identified, and a malignant outcome was reported at excision for 51 cases (17.8%). Among the 149 cases of pure LN, an increased risk of malignancy emerged in women in mammographic categories R4-R5 as compared with those in categories R2-R3 (OR 2.46; P = 0.048). In the series, a statistically significant decreased malignancy risk emerged among cases without determinant microcalcifications (P = 0.04).

CONCLUSIONS

Our results suggest that the diagnosis of pure LN on VANCB warrants follow-up excision, because clinicopathological parameters do not allow the prediction of which cases will present carcinoma at surgical excision.

Authors+Show Affiliations

Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy. simonetta.bianchi@unifi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23692123

Citation

Bianchi, Simonetta, et al. "Morphological Parameters of Lobular in Situ Neoplasia in Stereotactic 11-gauge Vacuum-assisted Needle Core Biopsy Do Not Predict the Presence of Malignancy On Subsequent Surgical Excision." Histopathology, vol. 63, no. 1, 2013, pp. 83-95.
Bianchi S, Bendinelli B, Castellano I, et al. Morphological parameters of lobular in situ neoplasia in stereotactic 11-gauge vacuum-assisted needle core biopsy do not predict the presence of malignancy on subsequent surgical excision. Histopathology. 2013;63(1):83-95.
Bianchi, S., Bendinelli, B., Castellano, I., Piubello, Q., Renne, G., Cattani, M. G., Stefano, D. D., Carrillo, G., Laurino, L., Bersiga, A., Giardina, C., Dante, S., Loreto, C. D., Quero, C., Antonacci, C. M., & Palli, D. (2013). Morphological parameters of lobular in situ neoplasia in stereotactic 11-gauge vacuum-assisted needle core biopsy do not predict the presence of malignancy on subsequent surgical excision. Histopathology, 63(1), 83-95. https://doi.org/10.1111/his.12139
Bianchi S, et al. Morphological Parameters of Lobular in Situ Neoplasia in Stereotactic 11-gauge Vacuum-assisted Needle Core Biopsy Do Not Predict the Presence of Malignancy On Subsequent Surgical Excision. Histopathology. 2013;63(1):83-95. PubMed PMID: 23692123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphological parameters of lobular in situ neoplasia in stereotactic 11-gauge vacuum-assisted needle core biopsy do not predict the presence of malignancy on subsequent surgical excision. AU - Bianchi,Simonetta, AU - Bendinelli,Benedetta, AU - Castellano,Isabella, AU - Piubello,Quirino, AU - Renne,Giuseppe, AU - Cattani,Maria Grazia, AU - Stefano,Domenica Di, AU - Carrillo,Giovanna, AU - Laurino,Licia, AU - Bersiga,Alessandra, AU - Giardina,Carmela, AU - Dante,Stefania, AU - Loreto,Carla Di, AU - Quero,Carmela, AU - Antonacci,Concetta Maria, AU - Palli,Domenico, AU - ,, Y1 - 2013/05/20/ PY - 2012/12/20/received PY - 2013/03/18/accepted PY - 2013/5/23/entrez PY - 2013/5/23/pubmed PY - 2014/3/7/medline SP - 83 EP - 95 JF - Histopathology JO - Histopathology VL - 63 IS - 1 N2 - AIMS: The management of lobular in situ neoplasia (LN) when diagnosed on core biopsy remains a controversial issue. The present study aimed to investigate the association between morphological parameters of LN on vacuum-assisted needle core biopsy (VANCB) and the presence of malignancy (ductal carcinoma in situ, pleomorphic lobular carcinoma in situ, or invasive carcinoma) at surgical excision (SE). METHODS AND RESULTS: The study included 14 pathology departments in Italy. Available slides from 859 cases of VANCB reporting an original diagnosis of flat epithelial atypia, atypical ductal hyperplasia or LN, all with subsequent surgical excision, were reviewed. Overall, 286 cases of LN, pure or associated with other lesions, were identified, and a malignant outcome was reported at excision for 51 cases (17.8%). Among the 149 cases of pure LN, an increased risk of malignancy emerged in women in mammographic categories R4-R5 as compared with those in categories R2-R3 (OR 2.46; P = 0.048). In the series, a statistically significant decreased malignancy risk emerged among cases without determinant microcalcifications (P = 0.04). CONCLUSIONS: Our results suggest that the diagnosis of pure LN on VANCB warrants follow-up excision, because clinicopathological parameters do not allow the prediction of which cases will present carcinoma at surgical excision. SN - 1365-2559 UR - https://www.unboundmedicine.com/medline/citation/23692123/Morphological_parameters_of_lobular_in_situ_neoplasia_in_stereotactic_11_gauge_vacuum_assisted_needle_core_biopsy_do_not_predict_the_presence_of_malignancy_on_subsequent_surgical_excision_ L2 - https://doi.org/10.1111/his.12139 DB - PRIME DP - Unbound Medicine ER -