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Association between dopamine Beta-hydroxylase gene polymorphisms and attention-deficit hyperactivity disorder in korean children.
Genet Test Mol Biomarkers 2013; 17(7):529-34GT

Abstract

Attention-deficit hyperactivity disorder (ADHD) is a common disorder of the school-age population. ADHD is familial, and genetic studies estimate heritability at 80%-90%. The aim of the present study was to investigate the association between the genetic type and alleles for the dopamine beta-hydroxylase (DBH) gene in Korean children with ADHD. The sample consisted of 142 ADHD children and 139 control children. We diagnosed ADHD according to DSM-IV. ADHD symptoms were evaluated with the Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 281 subjects; DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for the DBH polymorphism. The alleles and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of the DBH gene polymorphism in the ADHD and control groups. This study showed that there was a significant correlation among the frequencies of rs1611115 (odds ratio=0.64, 95% confidence interval=0.42-0.97, p=0.034) of the alleles of DBH, but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggested that DBH might be related to ADHD symptoms.

Authors+Show Affiliations

Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23692268

Citation

Kwon, Ho Jang, and Myung Ho Lim. "Association Between Dopamine Beta-hydroxylase Gene Polymorphisms and Attention-deficit Hyperactivity Disorder in Korean Children." Genetic Testing and Molecular Biomarkers, vol. 17, no. 7, 2013, pp. 529-34.
Kwon HJ, Lim MH. Association between dopamine Beta-hydroxylase gene polymorphisms and attention-deficit hyperactivity disorder in korean children. Genet Test Mol Biomarkers. 2013;17(7):529-34.
Kwon, H. J., & Lim, M. H. (2013). Association between dopamine Beta-hydroxylase gene polymorphisms and attention-deficit hyperactivity disorder in korean children. Genetic Testing and Molecular Biomarkers, 17(7), pp. 529-34. doi:10.1089/gtmb.2013.0072.
Kwon HJ, Lim MH. Association Between Dopamine Beta-hydroxylase Gene Polymorphisms and Attention-deficit Hyperactivity Disorder in Korean Children. Genet Test Mol Biomarkers. 2013;17(7):529-34. PubMed PMID: 23692268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between dopamine Beta-hydroxylase gene polymorphisms and attention-deficit hyperactivity disorder in korean children. AU - Kwon,Ho Jang, AU - Lim,Myung Ho, Y1 - 2013/05/21/ PY - 2013/5/23/entrez PY - 2013/5/23/pubmed PY - 2014/2/13/medline SP - 529 EP - 34 JF - Genetic testing and molecular biomarkers JO - Genet Test Mol Biomarkers VL - 17 IS - 7 N2 - Attention-deficit hyperactivity disorder (ADHD) is a common disorder of the school-age population. ADHD is familial, and genetic studies estimate heritability at 80%-90%. The aim of the present study was to investigate the association between the genetic type and alleles for the dopamine beta-hydroxylase (DBH) gene in Korean children with ADHD. The sample consisted of 142 ADHD children and 139 control children. We diagnosed ADHD according to DSM-IV. ADHD symptoms were evaluated with the Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 281 subjects; DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for the DBH polymorphism. The alleles and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of the DBH gene polymorphism in the ADHD and control groups. This study showed that there was a significant correlation among the frequencies of rs1611115 (odds ratio=0.64, 95% confidence interval=0.42-0.97, p=0.034) of the alleles of DBH, but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggested that DBH might be related to ADHD symptoms. SN - 1945-0257 UR - https://www.unboundmedicine.com/medline/citation/23692268/Association_between_dopamine_Beta_hydroxylase_gene_polymorphisms_and_attention_deficit_hyperactivity_disorder_in_korean_children_ L2 - https://www.liebertpub.com/doi/full/10.1089/gtmb.2013.0072?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -