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Helicobacter pylori infection and normal colorectal mucosa-adenomatous polyp-adenocarcinoma sequence: a meta-analysis of 27 case-control studies.
Colorectal Dis. 2014 Apr; 16(4):246-52.CD

Abstract

AIM

The study aimed to determine whether Helicobacter pylori infection is associated with colorectal adenocarcinoma and to quantify the extent of the risk.

METHOD

A literature search was performed to identify studies published between 1995 and 2012 for relevant risk estimates. Fixed and random effect meta-analytical techniques were conducted for colorectal adenocarcinoma and adenomatous polyp.

RESULTS

Twenty-seven case-controlled studies involving 3450 adenocarcinoma patients, 1304 adenomatous polyp patients and more than 4000 controls were included. Helicobacter pylori was associated with an increased risk of colorectal adenocarcinoma and adenomatous polyp [odds ratio (OR) 1.24, 95% CI 1.12-1.37, P = 0.66; OR 1.87, 95% CI 1.53-2.28, P = 0.81]. There was a significant association between the CagA-positive strain and adenocarcinoma risk (OR 1.22, 95% CI 1.08-1.37, P = 0.05). In addition, there was an increased risk of tubular adenoma and villous adenoma formation (OR 3.06, 95% CI 1.98-4.73, P = 0.14; OR 2.05, 95% CI 0.84-4.97, P = 0.86).

CONCLUSION

The meta-analysis suggests a promoting effect of Helicobacter pylori on the risk of adenocarcinoma. It also suggests that Helicobacter infection might have its influence at the start of the adenomatous polyp disease sequence.

Authors+Show Affiliations

Department of Internal Medicine, Tianjin Union Medicine Center & Tianjin People's Hospital, Tianjin, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23692360

Citation

Wang, F, et al. "Helicobacter Pylori Infection and Normal Colorectal Mucosa-adenomatous Polyp-adenocarcinoma Sequence: a Meta-analysis of 27 Case-control Studies." Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, vol. 16, no. 4, 2014, pp. 246-52.
Wang F, Sun MY, Shi SL, et al. Helicobacter pylori infection and normal colorectal mucosa-adenomatous polyp-adenocarcinoma sequence: a meta-analysis of 27 case-control studies. Colorectal Dis. 2014;16(4):246-52.
Wang, F., Sun, M. Y., Shi, S. L., & Lv, Z. S. (2014). Helicobacter pylori infection and normal colorectal mucosa-adenomatous polyp-adenocarcinoma sequence: a meta-analysis of 27 case-control studies. Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, 16(4), 246-52. https://doi.org/10.1111/codi.12290
Wang F, et al. Helicobacter Pylori Infection and Normal Colorectal Mucosa-adenomatous Polyp-adenocarcinoma Sequence: a Meta-analysis of 27 Case-control Studies. Colorectal Dis. 2014;16(4):246-52. PubMed PMID: 23692360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection and normal colorectal mucosa-adenomatous polyp-adenocarcinoma sequence: a meta-analysis of 27 case-control studies. AU - Wang,F, AU - Sun,M Y, AU - Shi,S L, AU - Lv,Z S, PY - 2012/12/02/received PY - 2013/02/20/accepted PY - 2013/5/23/entrez PY - 2013/5/23/pubmed PY - 2014/11/6/medline KW - Colorectal neoplasms KW - adenomatous polyps KW - bacteria KW - helicobacter pylori KW - meta-analysis SP - 246 EP - 52 JF - Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland JO - Colorectal Dis VL - 16 IS - 4 N2 - AIM: The study aimed to determine whether Helicobacter pylori infection is associated with colorectal adenocarcinoma and to quantify the extent of the risk. METHOD: A literature search was performed to identify studies published between 1995 and 2012 for relevant risk estimates. Fixed and random effect meta-analytical techniques were conducted for colorectal adenocarcinoma and adenomatous polyp. RESULTS: Twenty-seven case-controlled studies involving 3450 adenocarcinoma patients, 1304 adenomatous polyp patients and more than 4000 controls were included. Helicobacter pylori was associated with an increased risk of colorectal adenocarcinoma and adenomatous polyp [odds ratio (OR) 1.24, 95% CI 1.12-1.37, P = 0.66; OR 1.87, 95% CI 1.53-2.28, P = 0.81]. There was a significant association between the CagA-positive strain and adenocarcinoma risk (OR 1.22, 95% CI 1.08-1.37, P = 0.05). In addition, there was an increased risk of tubular adenoma and villous adenoma formation (OR 3.06, 95% CI 1.98-4.73, P = 0.14; OR 2.05, 95% CI 0.84-4.97, P = 0.86). CONCLUSION: The meta-analysis suggests a promoting effect of Helicobacter pylori on the risk of adenocarcinoma. It also suggests that Helicobacter infection might have its influence at the start of the adenomatous polyp disease sequence. SN - 1463-1318 UR - https://www.unboundmedicine.com/medline/citation/23692360/Helicobacter_pylori_infection_and_normal_colorectal_mucosa_adenomatous_polyp_adenocarcinoma_sequence:_a_meta_analysis_of_27_case_control_studies_ L2 - https://doi.org/10.1111/codi.12290 DB - PRIME DP - Unbound Medicine ER -