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Antinociceptive and antiallodynic effects of Momordica charantia L. in tibial and sural nerve transection-induced neuropathic pain in rats.
Nutr Neurosci. 2014 Feb; 17(2):88-96.NN

Abstract

OBJECTIVE

This study was designed to investigate the ameliorative potential of Momordica charantia L. (MC) in tibial and sural nerve transection (TST)-induced neuropathic pain in rats.

MATERIALS AND METHODS

TST was performed by sectioning tibial and sural nerve portions (2 mm) of the sciatic nerve, and leaving the common peroneal nerve intact. Acetone drop, pin-prick, hot plate, paint-brush, and walking track tests were performed to assess cold allodynia, mechanical and heat hyperalgesia, and dynamic mechanical allodynia and tibial functional index, respectively. The levels of tumour necrosis factor (TNF)-alpha and thio-barbituric acid reactive substances (TBARS) were measured in the sciatic nerve as an index of inflammation and oxidative stress. MC (all doses, orally, once daily) was administered to the rats for 24 consecutive days.

RESULTS

TST led to significant development of cold allodynia, mechanical and heat hyperalgesia, dynamic mechanical allodynia, and functional deficit in walking along with rise in the levels of TBARS and TNF-alpha. Administration of MC (200, 400, and 800 mg/kg) significantly attenuated TST-induced behavioural and biochemical changes. Furthermore, pretreatment of BADGE (120 mg/kg, intraperitoneally) abolished the protective effect of MC in TST-induced neuropathic pain.

CONCLUSIONS

Collectively, it is speculated that PPAR-gamma agonistic activity, anti-inflammatory, and antioxidative potential is critical for antinociceptive effect of MC in neuropathic pain.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23692809

Citation

Jain, Vivek, et al. "Antinociceptive and Antiallodynic Effects of Momordica Charantia L. in Tibial and Sural Nerve Transection-induced Neuropathic Pain in Rats." Nutritional Neuroscience, vol. 17, no. 2, 2014, pp. 88-96.
Jain V, Pareek A, Paliwal N, et al. Antinociceptive and antiallodynic effects of Momordica charantia L. in tibial and sural nerve transection-induced neuropathic pain in rats. Nutr Neurosci. 2014;17(2):88-96.
Jain, V., Pareek, A., Paliwal, N., Ratan, Y., Jaggi, A. S., & Singh, N. (2014). Antinociceptive and antiallodynic effects of Momordica charantia L. in tibial and sural nerve transection-induced neuropathic pain in rats. Nutritional Neuroscience, 17(2), 88-96. https://doi.org/10.1179/1476830513Y.0000000069
Jain V, et al. Antinociceptive and Antiallodynic Effects of Momordica Charantia L. in Tibial and Sural Nerve Transection-induced Neuropathic Pain in Rats. Nutr Neurosci. 2014;17(2):88-96. PubMed PMID: 23692809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and antiallodynic effects of Momordica charantia L. in tibial and sural nerve transection-induced neuropathic pain in rats. AU - Jain,Vivek, AU - Pareek,Ashutosh, AU - Paliwal,Nishant, AU - Ratan,Yashumati, AU - Jaggi,Amteshwar Singh, AU - Singh,Nirmal, Y1 - 2013/11/26/ PY - 2013/5/23/entrez PY - 2013/5/23/pubmed PY - 2014/9/16/medline KW - BADGE KW - Inflammation KW - Momordica charantia L. KW - Neuropathic pain KW - PPAR-gamma KW - TNF-alpha SP - 88 EP - 96 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 17 IS - 2 N2 - OBJECTIVE: This study was designed to investigate the ameliorative potential of Momordica charantia L. (MC) in tibial and sural nerve transection (TST)-induced neuropathic pain in rats. MATERIALS AND METHODS: TST was performed by sectioning tibial and sural nerve portions (2 mm) of the sciatic nerve, and leaving the common peroneal nerve intact. Acetone drop, pin-prick, hot plate, paint-brush, and walking track tests were performed to assess cold allodynia, mechanical and heat hyperalgesia, and dynamic mechanical allodynia and tibial functional index, respectively. The levels of tumour necrosis factor (TNF)-alpha and thio-barbituric acid reactive substances (TBARS) were measured in the sciatic nerve as an index of inflammation and oxidative stress. MC (all doses, orally, once daily) was administered to the rats for 24 consecutive days. RESULTS: TST led to significant development of cold allodynia, mechanical and heat hyperalgesia, dynamic mechanical allodynia, and functional deficit in walking along with rise in the levels of TBARS and TNF-alpha. Administration of MC (200, 400, and 800 mg/kg) significantly attenuated TST-induced behavioural and biochemical changes. Furthermore, pretreatment of BADGE (120 mg/kg, intraperitoneally) abolished the protective effect of MC in TST-induced neuropathic pain. CONCLUSIONS: Collectively, it is speculated that PPAR-gamma agonistic activity, anti-inflammatory, and antioxidative potential is critical for antinociceptive effect of MC in neuropathic pain. SN - 1476-8305 UR - https://www.unboundmedicine.com/medline/citation/23692809/Antinociceptive_and_antiallodynic_effects_of_Momordica_charantia_L__in_tibial_and_sural_nerve_transection_induced_neuropathic_pain_in_rats_ L2 - https://www.tandfonline.com/doi/full/10.1179/1476830513Y.0000000069 DB - PRIME DP - Unbound Medicine ER -