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Graphene and CdS nanocomposite: a facile interface for construction of DNA-based electrochemical biosensor and its application to the determination of phenformin.
Colloids Surf B Biointerfaces. 2013 Oct 01; 110:8-14.CS

Abstract

Graphene/cadmium sulphide (GR-CdS) nanocomposite was synthesized via a low temperature process in aqueous solution. The as-prepared nanocomposite was characterized by scanning electron microscopy, UV-visible spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. The impedance analysis indicated that GR-CdS nanocomposite possessed outstanding electrochemical performance for facile electron transfer. When DNA was immobilized on GR-CdS (DNA/GR-CdS) modified electrode, the electrochemical oxidation of guanine and adenine in DNA residue bases was significantly promoted. Due to the interaction of DNA with phenformin, the voltammetric current of guanine or adenine on the DNA/GR-CdS electrode was decreased when phenformin was present in the electrolytic solution. Under optimized conditions, the signal of guanine on DNA/GR-CdS electrode decreased linearly with increasing the concentration of phenformin in the range of 1.0×10(-6)molL(-1) to 1.0×10(-3)molL(-1). The proposed DNA-based electrochemical biosensor was successfully applied to the determination of phenformin in real samples.

Authors+Show Affiliations

School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan 430074, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23693034

Citation

Zeng, Lijiao, et al. "Graphene and CdS Nanocomposite: a Facile Interface for Construction of DNA-based Electrochemical Biosensor and Its Application to the Determination of Phenformin." Colloids and Surfaces. B, Biointerfaces, vol. 110, 2013, pp. 8-14.
Zeng L, Wang R, Zhu L, et al. Graphene and CdS nanocomposite: a facile interface for construction of DNA-based electrochemical biosensor and its application to the determination of phenformin. Colloids Surf B Biointerfaces. 2013;110:8-14.
Zeng, L., Wang, R., Zhu, L., & Zhang, J. (2013). Graphene and CdS nanocomposite: a facile interface for construction of DNA-based electrochemical biosensor and its application to the determination of phenformin. Colloids and Surfaces. B, Biointerfaces, 110, 8-14. https://doi.org/10.1016/j.colsurfb.2013.04.025
Zeng L, et al. Graphene and CdS Nanocomposite: a Facile Interface for Construction of DNA-based Electrochemical Biosensor and Its Application to the Determination of Phenformin. Colloids Surf B Biointerfaces. 2013 Oct 1;110:8-14. PubMed PMID: 23693034.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Graphene and CdS nanocomposite: a facile interface for construction of DNA-based electrochemical biosensor and its application to the determination of phenformin. AU - Zeng,Lijiao, AU - Wang,Rui, AU - Zhu,Lihua, AU - Zhang,Jingdong, Y1 - 2013/04/28/ PY - 2012/12/07/received PY - 2013/03/22/revised PY - 2013/04/22/accepted PY - 2013/5/23/entrez PY - 2013/5/23/pubmed PY - 2014/1/22/medline SP - 8 EP - 14 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 110 N2 - Graphene/cadmium sulphide (GR-CdS) nanocomposite was synthesized via a low temperature process in aqueous solution. The as-prepared nanocomposite was characterized by scanning electron microscopy, UV-visible spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. The impedance analysis indicated that GR-CdS nanocomposite possessed outstanding electrochemical performance for facile electron transfer. When DNA was immobilized on GR-CdS (DNA/GR-CdS) modified electrode, the electrochemical oxidation of guanine and adenine in DNA residue bases was significantly promoted. Due to the interaction of DNA with phenformin, the voltammetric current of guanine or adenine on the DNA/GR-CdS electrode was decreased when phenformin was present in the electrolytic solution. Under optimized conditions, the signal of guanine on DNA/GR-CdS electrode decreased linearly with increasing the concentration of phenformin in the range of 1.0×10(-6)molL(-1) to 1.0×10(-3)molL(-1). The proposed DNA-based electrochemical biosensor was successfully applied to the determination of phenformin in real samples. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/23693034/Graphene_and_CdS_nanocomposite:_a_facile_interface_for_construction_of_DNA_based_electrochemical_biosensor_and_its_application_to_the_determination_of_phenformin_ DB - PRIME DP - Unbound Medicine ER -