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Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice.
Am J Physiol Endocrinol Metab. 2013 Jul 15; 305(2):E171-82.AJ

Abstract

The importance of adequate levels of muscle size and function and physical activity is widely recognized. Myostatin/activin blocking increases skeletal muscle mass but may decrease muscle oxidative capacity and can thus be hypothesized to affect voluntary physical activity. Soluble activin receptor IIB (sActRIIB-Fc) was produced to block myostatin/activins. Modestly dystrophic mdx mice were injected with sActRIIB-Fc or PBS with or without voluntary wheel running exercise for 7 wk. Healthy mice served as controls. Running for 7 wk attenuated the sActRIIB-Fc-induced increase in body mass by decreasing fat mass. Running also enhanced/restored the markers of muscle oxidative capacity and autophagy in mdx mice to or above the levels of healthy mice. Voluntary running activity was decreased by sActRIIB-Fc during the first 3-4 wk correlating with increased body mass. Home cage physical activity of mice, quantified from the force plate signal, was decreased by sActRIIB-Fc the whole 7-wk treatment in sedentary mice. To understand what happens during the first weeks after sActRIIB-Fc administration, when mice are less active, healthy mice were injected with sActRIIB-Fc or PBS for 2 wk. During the sActRIIB-Fc-induced rapid 2-wk muscle growth period, oxidative capacity and autophagy were reduced, which may possibly explain the decreased running activity. These results show that increased muscle size and decreased markers of oxidative capacity and autophagy during the first weeks of myostatin/activin blocking are associated with decreased voluntary activity levels. Voluntary exercise in dystrophic mice enhances the markers of oxidative capacity and autophagy to or above the levels of healthy mice.

Authors+Show Affiliations

Department of Biology of Physical Activity, Neuromuscular Research Center, University of Jyväskylä, Finland. juha.hulmi@jyu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23695214

Citation

Hulmi, Juha J., et al. "Exercise Restores Decreased Physical Activity Levels and Increases Markers of Autophagy and Oxidative Capacity in Myostatin/activin-blocked Mdx Mice." American Journal of Physiology. Endocrinology and Metabolism, vol. 305, no. 2, 2013, pp. E171-82.
Hulmi JJ, Oliveira BM, Silvennoinen M, et al. Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice. Am J Physiol Endocrinol Metab. 2013;305(2):E171-82.
Hulmi, J. J., Oliveira, B. M., Silvennoinen, M., Hoogaars, W. M., Pasternack, A., Kainulainen, H., & Ritvos, O. (2013). Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice. American Journal of Physiology. Endocrinology and Metabolism, 305(2), E171-82. https://doi.org/10.1152/ajpendo.00065.2013
Hulmi JJ, et al. Exercise Restores Decreased Physical Activity Levels and Increases Markers of Autophagy and Oxidative Capacity in Myostatin/activin-blocked Mdx Mice. Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E171-82. PubMed PMID: 23695214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice. AU - Hulmi,Juha J, AU - Oliveira,Bernardo M, AU - Silvennoinen,Mika, AU - Hoogaars,Willem M H, AU - Pasternack,Arja, AU - Kainulainen,Heikki, AU - Ritvos,Olli, Y1 - 2013/05/21/ PY - 2013/5/23/entrez PY - 2013/5/23/pubmed PY - 2013/9/21/medline KW - activin receptor IIB KW - exercise KW - hypertrophy KW - myostatin KW - skeletal muscle SP - E171 EP - 82 JF - American journal of physiology. Endocrinology and metabolism JO - Am. J. Physiol. Endocrinol. Metab. VL - 305 IS - 2 N2 - The importance of adequate levels of muscle size and function and physical activity is widely recognized. Myostatin/activin blocking increases skeletal muscle mass but may decrease muscle oxidative capacity and can thus be hypothesized to affect voluntary physical activity. Soluble activin receptor IIB (sActRIIB-Fc) was produced to block myostatin/activins. Modestly dystrophic mdx mice were injected with sActRIIB-Fc or PBS with or without voluntary wheel running exercise for 7 wk. Healthy mice served as controls. Running for 7 wk attenuated the sActRIIB-Fc-induced increase in body mass by decreasing fat mass. Running also enhanced/restored the markers of muscle oxidative capacity and autophagy in mdx mice to or above the levels of healthy mice. Voluntary running activity was decreased by sActRIIB-Fc during the first 3-4 wk correlating with increased body mass. Home cage physical activity of mice, quantified from the force plate signal, was decreased by sActRIIB-Fc the whole 7-wk treatment in sedentary mice. To understand what happens during the first weeks after sActRIIB-Fc administration, when mice are less active, healthy mice were injected with sActRIIB-Fc or PBS for 2 wk. During the sActRIIB-Fc-induced rapid 2-wk muscle growth period, oxidative capacity and autophagy were reduced, which may possibly explain the decreased running activity. These results show that increased muscle size and decreased markers of oxidative capacity and autophagy during the first weeks of myostatin/activin blocking are associated with decreased voluntary activity levels. Voluntary exercise in dystrophic mice enhances the markers of oxidative capacity and autophagy to or above the levels of healthy mice. SN - 1522-1555 UR - https://www.unboundmedicine.com/medline/citation/23695214/Exercise_restores_decreased_physical_activity_levels_and_increases_markers_of_autophagy_and_oxidative_capacity_in_myostatin/activin_blocked_mdx_mice_ L2 - http://www.physiology.org/doi/full/10.1152/ajpendo.00065.2013?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -