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Body mass index and risk of gastric cancer: a meta-analysis of a population with more than ten million from 24 prospective studies.

Abstract

BACKGROUND

To provide a quantitative assessment of the association between body mass index (BMI) and the risk of gastric cancer, we summarized the evidence from prospective studies.

METHODS

Eligible studies published up to November 30, 2012, were retrieved via computer searches of MEDLINE and EMBASE as well as manual review of references. Summary relative risks (SRR) with their corresponding 95% confidence intervals (CI) were calculated using a random-effects model.

RESULTS

A total of 24 prospective studies of BMI and gastric cancer risk with 41,791 cases were included in our analysis. Overall, both overweight (BMI, 25-30 kg/m(2)) and obesity (BMI, ≥30 kg/m(2)) were not associated with risk of total gastric cancer (overweight: SRR, 1.01; 95% CI, 0.96-1.07; obesity: SRR, 1.06; 95% CI, 0.99-1.12). Furthermore, we found increased BMI was positively associated with the risk of gastric cardia cancer (GCC; SRR = 1.21 for overweight and 1.82 for obesity), but not with gastric non-cardia cancer (GNCC; SRR = 0.93 for overweight and SRR = 1.00 for obesity). Similar results were observed in a linear dose-response analysis.

CONCLUSION

On the basis of meta-analysis of prospective studies, we find high BMI is positively associated with the risk of GCCs but not with GNCCs.

IMPACT

(i) On the basis of more definite and quantitative evidence than previously available, we found that increasing BMI was not a clear risk factor for total gastric cancer. (ii) Increased BMI was positively associated with risk of GCC but not with GNCCs.

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  • Authors+Show Affiliations

    ,

    Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.

    , , , , , ,

    Source

    MeSH

    Body Mass Index
    Female
    Humans
    Male
    Obesity
    Prospective Studies
    Risk Assessment
    Risk Factors
    Stomach Neoplasms

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    23697611

    Citation

    Chen, Yi, et al. "Body Mass Index and Risk of Gastric Cancer: a Meta-analysis of a Population With More Than Ten Million From 24 Prospective Studies." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 22, no. 8, 2013, pp. 1395-408.
    Chen Y, Liu L, Wang X, et al. Body mass index and risk of gastric cancer: a meta-analysis of a population with more than ten million from 24 prospective studies. Cancer Epidemiol Biomarkers Prev. 2013;22(8):1395-408.
    Chen, Y., Liu, L., Wang, X., Wang, J., Yan, Z., Cheng, J., ... Li, G. (2013). Body mass index and risk of gastric cancer: a meta-analysis of a population with more than ten million from 24 prospective studies. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 22(8), pp. 1395-408. doi:10.1158/1055-9965.EPI-13-0042.
    Chen Y, et al. Body Mass Index and Risk of Gastric Cancer: a Meta-analysis of a Population With More Than Ten Million From 24 Prospective Studies. Cancer Epidemiol Biomarkers Prev. 2013;22(8):1395-408. PubMed PMID: 23697611.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body mass index and risk of gastric cancer: a meta-analysis of a population with more than ten million from 24 prospective studies. AU - Chen,Yi, AU - Liu,Lingxiao, AU - Wang,Xiaolin, AU - Wang,Jianhua, AU - Yan,Zhiping, AU - Cheng,Jieming, AU - Gong,Gaoquan, AU - Li,Guoping, Y1 - 2013/05/22/ PY - 2013/5/24/entrez PY - 2013/5/24/pubmed PY - 2013/11/7/medline SP - 1395 EP - 408 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 22 IS - 8 N2 - BACKGROUND: To provide a quantitative assessment of the association between body mass index (BMI) and the risk of gastric cancer, we summarized the evidence from prospective studies. METHODS: Eligible studies published up to November 30, 2012, were retrieved via computer searches of MEDLINE and EMBASE as well as manual review of references. Summary relative risks (SRR) with their corresponding 95% confidence intervals (CI) were calculated using a random-effects model. RESULTS: A total of 24 prospective studies of BMI and gastric cancer risk with 41,791 cases were included in our analysis. Overall, both overweight (BMI, 25-30 kg/m(2)) and obesity (BMI, ≥30 kg/m(2)) were not associated with risk of total gastric cancer (overweight: SRR, 1.01; 95% CI, 0.96-1.07; obesity: SRR, 1.06; 95% CI, 0.99-1.12). Furthermore, we found increased BMI was positively associated with the risk of gastric cardia cancer (GCC; SRR = 1.21 for overweight and 1.82 for obesity), but not with gastric non-cardia cancer (GNCC; SRR = 0.93 for overweight and SRR = 1.00 for obesity). Similar results were observed in a linear dose-response analysis. CONCLUSION: On the basis of meta-analysis of prospective studies, we find high BMI is positively associated with the risk of GCCs but not with GNCCs. IMPACT: (i) On the basis of more definite and quantitative evidence than previously available, we found that increasing BMI was not a clear risk factor for total gastric cancer. (ii) Increased BMI was positively associated with risk of GCC but not with GNCCs. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/23697611/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=23697611 DB - PRIME DP - Unbound Medicine ER -