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Dietary fat in breast cancer survival.
Annu Rev Nutr 2013; 33:319-48AR

Abstract

Laboratory evidence suggests a plausible role for dietary fat in breast cancer pathophysiology. We conducted a systematic literature review to assess the epidemiological evidence on the impact of total dietary fat and fat subtypes, measured pre- and/or postcancer diagnosis, in relation to breast cancer-specific and all-cause mortality among breast cancer survivors. Studies were included if they were in English, had a sample size ≥200, and presented the hazard ratio/rate ratio for recurrence, disease-specific mortality, or all-cause mortality (n = 18). Although the results are mixed, most studies suggested that higher saturated fat intake prediagnosis was associated with increased risk of breast cancer-specific and all-cause mortality. Postdiagnostic trans fat intake was associated with a 45% and 78% increased risk of all-cause mortality. Higher monounsaturated fat intake before and after diagnosis was generally associated with increased risk of all-cause and breast cancer-specific mortality, albeit the majority of the studies were statistically nonsignificant. Two studies evaluating omega-3 fat intake suggested an inverse association with all-cause mortality. Although there were too few studies on fat subtypes to draw definitive conclusions, high consumption of saturated fat may exert a detrimental effect on breast cancer-specific and all-cause mortality, whereas omega-3 fat may be beneficial. The inconsistent and limited evidence warrants research to assess the impact of consumption of fat subtypes on breast cancer recurrence and mortality.

Authors+Show Affiliations

Department of Nutrition, Food Studies and Public Health, New York University, New York, NY 10003, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

23701588

Citation

Makarem, Nour, et al. "Dietary Fat in Breast Cancer Survival." Annual Review of Nutrition, vol. 33, 2013, pp. 319-48.
Makarem N, Chandran U, Bandera EV, et al. Dietary fat in breast cancer survival. Annu Rev Nutr. 2013;33:319-48.
Makarem, N., Chandran, U., Bandera, E. V., & Parekh, N. (2013). Dietary fat in breast cancer survival. Annual Review of Nutrition, 33, pp. 319-48. doi:10.1146/annurev-nutr-112912-095300.
Makarem N, et al. Dietary Fat in Breast Cancer Survival. Annu Rev Nutr. 2013;33:319-48. PubMed PMID: 23701588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat in breast cancer survival. AU - Makarem,Nour, AU - Chandran,Urmila, AU - Bandera,Elisa V, AU - Parekh,Niyati, Y1 - 2013/05/22/ PY - 2013/5/25/entrez PY - 2013/5/25/pubmed PY - 2014/2/14/medline SP - 319 EP - 48 JF - Annual review of nutrition JO - Annu. Rev. Nutr. VL - 33 N2 - Laboratory evidence suggests a plausible role for dietary fat in breast cancer pathophysiology. We conducted a systematic literature review to assess the epidemiological evidence on the impact of total dietary fat and fat subtypes, measured pre- and/or postcancer diagnosis, in relation to breast cancer-specific and all-cause mortality among breast cancer survivors. Studies were included if they were in English, had a sample size ≥200, and presented the hazard ratio/rate ratio for recurrence, disease-specific mortality, or all-cause mortality (n = 18). Although the results are mixed, most studies suggested that higher saturated fat intake prediagnosis was associated with increased risk of breast cancer-specific and all-cause mortality. Postdiagnostic trans fat intake was associated with a 45% and 78% increased risk of all-cause mortality. Higher monounsaturated fat intake before and after diagnosis was generally associated with increased risk of all-cause and breast cancer-specific mortality, albeit the majority of the studies were statistically nonsignificant. Two studies evaluating omega-3 fat intake suggested an inverse association with all-cause mortality. Although there were too few studies on fat subtypes to draw definitive conclusions, high consumption of saturated fat may exert a detrimental effect on breast cancer-specific and all-cause mortality, whereas omega-3 fat may be beneficial. The inconsistent and limited evidence warrants research to assess the impact of consumption of fat subtypes on breast cancer recurrence and mortality. SN - 1545-4312 UR - https://www.unboundmedicine.com/medline/citation/23701588/full_citation L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev-nutr-112912-095300?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -