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Effects of carnosine plus vitamin E and betaine treatments on oxidative stress in some tissues of aged rats.
Curr Aging Sci 2013; 6(2):199-205CA

Abstract

Oxidative stress plays an important role in aging. Effects of several antioxidants on age-related oxidative stress have been investigated. Carnosine (CAR) and betaine have antioxidant actions. The combination of CAR with vitamin E(CAR+E) increases its antioxidant efficiency. We investigated the effects of CAR+E and betaine treatments on oxidative and antioxidative status in liver, heart and brain tissues of aged rats. Experiments were carried out on young (5 months)and aged (22 months) male Wistar rats. Aged rats were given CAR (250 mg/kg; i.p.; 5 days per week) and vitamin E (200mg/kg; i.m.; twice per week) or betaine (1% w/v) for two months. Malondialdehyde (MDA) and diene conjugate (DC)levels and antioxidants were measured. MDA and DC levels were higher in tissues of aged rats than young rats. Glutathione(GSH) levels decreased in liver, but not heart and brain. There were no changes in vitamin E and vitamin C levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities in tissues of aged rats. CAR+E treatment was observed to decrease MDA and DC levels in tissues of aged rats. However, betaine decreased only hepatic MDA and DC levels. Both CAR+E and betaine increased hepatic GSH and vitamin E levels, but these treatments did not affect antioxidant enzyme activities. These results suggest that CAR+E treatment seems to be useful to decrease oxidative stress in liver, heart and brain tissues, but betaine is only effective in liver tissue of aged rats.

Authors+Show Affiliations

Department of Biochemistry, Yeditepe University Medical Faculty, Kayısdagi, Istanbul,Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23701646

Citation

Çoban, Jale, et al. "Effects of Carnosine Plus Vitamin E and Betaine Treatments On Oxidative Stress in some Tissues of Aged Rats." Current Aging Science, vol. 6, no. 2, 2013, pp. 199-205.
Çoban J, Bingül I, Yesil-Mizrak K, et al. Effects of carnosine plus vitamin E and betaine treatments on oxidative stress in some tissues of aged rats. Curr Aging Sci. 2013;6(2):199-205.
Çoban, J., Bingül, I., Yesil-Mizrak, K., Dogru-Abbasoglu, S., Oztezcan, S., & Uysal, M. (2013). Effects of carnosine plus vitamin E and betaine treatments on oxidative stress in some tissues of aged rats. Current Aging Science, 6(2), pp. 199-205.
Çoban J, et al. Effects of Carnosine Plus Vitamin E and Betaine Treatments On Oxidative Stress in some Tissues of Aged Rats. Curr Aging Sci. 2013;6(2):199-205. PubMed PMID: 23701646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of carnosine plus vitamin E and betaine treatments on oxidative stress in some tissues of aged rats. AU - Çoban,Jale, AU - Bingül,Ilknur, AU - Yesil-Mizrak,Kubra, AU - Dogru-Abbasoglu,Semra, AU - Oztezcan,Serdar, AU - Uysal,Mujdat, PY - 2012/09/12/received PY - 2013/05/07/revised PY - 2013/05/18/accepted PY - 2013/5/25/entrez PY - 2013/5/25/pubmed PY - 2014/2/28/medline SP - 199 EP - 205 JF - Current aging science JO - Curr Aging Sci VL - 6 IS - 2 N2 - Oxidative stress plays an important role in aging. Effects of several antioxidants on age-related oxidative stress have been investigated. Carnosine (CAR) and betaine have antioxidant actions. The combination of CAR with vitamin E(CAR+E) increases its antioxidant efficiency. We investigated the effects of CAR+E and betaine treatments on oxidative and antioxidative status in liver, heart and brain tissues of aged rats. Experiments were carried out on young (5 months)and aged (22 months) male Wistar rats. Aged rats were given CAR (250 mg/kg; i.p.; 5 days per week) and vitamin E (200mg/kg; i.m.; twice per week) or betaine (1% w/v) for two months. Malondialdehyde (MDA) and diene conjugate (DC)levels and antioxidants were measured. MDA and DC levels were higher in tissues of aged rats than young rats. Glutathione(GSH) levels decreased in liver, but not heart and brain. There were no changes in vitamin E and vitamin C levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities in tissues of aged rats. CAR+E treatment was observed to decrease MDA and DC levels in tissues of aged rats. However, betaine decreased only hepatic MDA and DC levels. Both CAR+E and betaine increased hepatic GSH and vitamin E levels, but these treatments did not affect antioxidant enzyme activities. These results suggest that CAR+E treatment seems to be useful to decrease oxidative stress in liver, heart and brain tissues, but betaine is only effective in liver tissue of aged rats. SN - 1874-6128 UR - https://www.unboundmedicine.com/medline/citation/23701646/Effects_of_carnosine_plus_vitamin_E_and_betaine_treatments_on_oxidative_stress_in_some_tissues_of_aged_rats_ L2 - http://www.eurekaselect.com/113226/article DB - PRIME DP - Unbound Medicine ER -