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Soluble epoxide hydrolase: gene structure, expression and deletion.
Gene. 2013 Sep 10; 526(2):61-74.GENE

Abstract

Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules, including the epoxyeicosatrienoic acids (EETs), epoxidized lipids produced from arachidonic acid by the action of cytochrome p450s. Through its metabolism of the EETs and other lipid mediators, sEH contributes to the regulation of vascular tone, nociception, angiogenesis and the inflammatory response. Because of its central physiological role in disease states such as cardiac hypertrophy, diabetes, hypertension, and pain sEH is being investigated as a therapeutic target. This review begins with a brief introduction to sEH protein structure and function. sEH evolution and gene structure are then discussed before human small nucleotide polymorphisms and mammalian gene expression are described in the context of several disease models. The review ends with an overview of studies that have employed the sEH knockout mouse model.

Authors+Show Affiliations

Department of Entomology and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23701967

Citation

Harris, Todd R., and Bruce D. Hammock. "Soluble Epoxide Hydrolase: Gene Structure, Expression and Deletion." Gene, vol. 526, no. 2, 2013, pp. 61-74.
Harris TR, Hammock BD. Soluble epoxide hydrolase: gene structure, expression and deletion. Gene. 2013;526(2):61-74.
Harris, T. R., & Hammock, B. D. (2013). Soluble epoxide hydrolase: gene structure, expression and deletion. Gene, 526(2), 61-74. https://doi.org/10.1016/j.gene.2013.05.008
Harris TR, Hammock BD. Soluble Epoxide Hydrolase: Gene Structure, Expression and Deletion. Gene. 2013 Sep 10;526(2):61-74. PubMed PMID: 23701967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble epoxide hydrolase: gene structure, expression and deletion. AU - Harris,Todd R, AU - Hammock,Bruce D, Y1 - 2013/05/20/ PY - 2012/12/11/received PY - 2013/03/29/revised PY - 2013/05/09/accepted PY - 2013/5/25/entrez PY - 2013/5/25/pubmed PY - 2013/10/19/medline KW - 20-HETE KW - 20-hydroxyeicosatetraenoic acid KW - 5-lipoxygenase activation protein KW - AP-1 KW - ARIC KW - ATF-6 KW - Ang-II KW - Atherosclerosis Risk in Communities KW - CAC KW - CARDIA KW - CPR KW - ChIP KW - Coronary Artery Risk Development in Young Adults KW - DHA KW - DHETs KW - EETs KW - EPA KW - EPHX2 KW - EpFAs KW - Epoxyeicosatrienoic acid KW - FLAP KW - GSIS KW - HUVECs KW - Hcy KW - Hypertension KW - IBD KW - IL-10 KW - Inflammation KW - LPS KW - Lipid signaling KW - NSAID KW - OVX KW - PPARs KW - RAAS KW - RBC KW - SHR KW - SNPs KW - SP-1 KW - STZ KW - THF KW - UPREs KW - UTR KW - VSM KW - WKY KW - Wistar-Kyoto KW - activating transcription factor-6 KW - activator protein 1 KW - angiotensin II KW - cardiopulmonary resuscitation KW - chromatin immunoprecipitation KW - coronary artery calcification KW - dihydroxyeicosatrienoic acids KW - docosahexaenoic acid KW - eNOS KW - eicosapentaenoic acid KW - endothelial nitric oxide synthase KW - epoxy-fatty acids KW - epoxyeicosatrienoic acids KW - glucose-stimulated insulin secretion KW - homocysteine KW - human umbilical vein endothelial cells KW - inflammatory bowel disease KW - interleukin-10 KW - lipopolysaccharide KW - nonsteroidal anti-inflammatory drug KW - ovariectomized KW - peroxisome-proliferator activated receptors KW - red blood cell KW - renin–angiotensin aldosterone system KW - sEH KW - single nucleotide polymorphisms KW - soluble epoxide hydrolase KW - specificity protein 1 KW - spontaneously hypertensive rat KW - streptozotocin KW - tetrahydrofuran KW - unfolded protein response elements KW - untranslated region KW - vascular smooth muscle SP - 61 EP - 74 JF - Gene JO - Gene VL - 526 IS - 2 N2 - Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules, including the epoxyeicosatrienoic acids (EETs), epoxidized lipids produced from arachidonic acid by the action of cytochrome p450s. Through its metabolism of the EETs and other lipid mediators, sEH contributes to the regulation of vascular tone, nociception, angiogenesis and the inflammatory response. Because of its central physiological role in disease states such as cardiac hypertrophy, diabetes, hypertension, and pain sEH is being investigated as a therapeutic target. This review begins with a brief introduction to sEH protein structure and function. sEH evolution and gene structure are then discussed before human small nucleotide polymorphisms and mammalian gene expression are described in the context of several disease models. The review ends with an overview of studies that have employed the sEH knockout mouse model. SN - 1879-0038 UR - https://www.unboundmedicine.com/medline/citation/23701967/Soluble_epoxide_hydrolase:_gene_structure_expression_and_deletion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(13)00617-3 DB - PRIME DP - Unbound Medicine ER -