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Muscle type and fiber type specificity in muscle wasting.
Int J Biochem Cell Biol. 2013 Oct; 45(10):2191-9.IJ

Abstract

Muscle wasting occurs in a variety of conditions, including both genetic diseases, such as muscular dystrophies, and acquired disorders, ranging from muscle disuse to cancer cachexia, from heart failure to aging sarcopenia. In most of these conditions, the loss of muscle tissue is not homogeneous, but involves specific muscle groups, for example Duchenne muscular dystrophy affects most body muscles but spares extraocular muscles, and other dystrophies affect selectively proximal or distal limb muscles. In addition, muscle atrophy can affect specific fiber types, involving predominantly slow type 1 or fast type 2 muscle fibers, and is frequently accompanied by a slow-to-fast or fast-to-slow fiber type shift. For example, muscle disuse, such as spinal cord injury, causes type 1 fiber atrophy with a slow-to-fast fiber type shift, whereas cancer cachexia leads to preferential atrophy of type 2 fibers with a fast-to-slow fiber type shift. The identification of the signaling pathways responsible for the differential response of muscles types and fiber types can lead to a better understanding of the pathogenesis of muscle wasting and to the design of therapeutic interventions appropriate for the specific disorders. This article is part of a Directed Issue entitled: Molecular basis of muscle wasting.

Authors+Show Affiliations

Venetian Institute of Molecular Medicine VIMM, Padova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23702032

Citation

Ciciliot, Stefano, et al. "Muscle Type and Fiber Type Specificity in Muscle Wasting." The International Journal of Biochemistry & Cell Biology, vol. 45, no. 10, 2013, pp. 2191-9.
Ciciliot S, Rossi AC, Dyar KA, et al. Muscle type and fiber type specificity in muscle wasting. Int J Biochem Cell Biol. 2013;45(10):2191-9.
Ciciliot, S., Rossi, A. C., Dyar, K. A., Blaauw, B., & Schiaffino, S. (2013). Muscle type and fiber type specificity in muscle wasting. The International Journal of Biochemistry & Cell Biology, 45(10), 2191-9. https://doi.org/10.1016/j.biocel.2013.05.016
Ciciliot S, et al. Muscle Type and Fiber Type Specificity in Muscle Wasting. Int J Biochem Cell Biol. 2013;45(10):2191-9. PubMed PMID: 23702032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Muscle type and fiber type specificity in muscle wasting. AU - Ciciliot,Stefano, AU - Rossi,Alberto C, AU - Dyar,Kenneth A, AU - Blaauw,Bert, AU - Schiaffino,Stefano, Y1 - 2013/05/21/ PY - 2013/03/25/received PY - 2013/05/13/revised PY - 2013/05/14/accepted PY - 2013/5/25/entrez PY - 2013/5/25/pubmed PY - 2014/7/1/medline KW - Cachexia KW - Muscle atrophy KW - Muscle disuse KW - Muscle fiber types KW - Muscular dystrophies KW - Sarcopenia SP - 2191 EP - 9 JF - The international journal of biochemistry & cell biology JO - Int J Biochem Cell Biol VL - 45 IS - 10 N2 - Muscle wasting occurs in a variety of conditions, including both genetic diseases, such as muscular dystrophies, and acquired disorders, ranging from muscle disuse to cancer cachexia, from heart failure to aging sarcopenia. In most of these conditions, the loss of muscle tissue is not homogeneous, but involves specific muscle groups, for example Duchenne muscular dystrophy affects most body muscles but spares extraocular muscles, and other dystrophies affect selectively proximal or distal limb muscles. In addition, muscle atrophy can affect specific fiber types, involving predominantly slow type 1 or fast type 2 muscle fibers, and is frequently accompanied by a slow-to-fast or fast-to-slow fiber type shift. For example, muscle disuse, such as spinal cord injury, causes type 1 fiber atrophy with a slow-to-fast fiber type shift, whereas cancer cachexia leads to preferential atrophy of type 2 fibers with a fast-to-slow fiber type shift. The identification of the signaling pathways responsible for the differential response of muscles types and fiber types can lead to a better understanding of the pathogenesis of muscle wasting and to the design of therapeutic interventions appropriate for the specific disorders. This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. SN - 1878-5875 UR - https://www.unboundmedicine.com/medline/citation/23702032/Muscle_type_and_fiber_type_specificity_in_muscle_wasting_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1357-2725(13)00153-2 DB - PRIME DP - Unbound Medicine ER -