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Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease.
Vet J. 2013 Oct; 198(1):70-5.VJ

Abstract

The outcome of spinal surgery in dogs with absent voluntary motor function and nociception following intervertebral disc (IVD) herniation is highly variable, which likely attests to differences in the severity of spinal cord damage. This retrospective study evaluated the extent to which neurological signs correlated with histologically detected spinal cord damage in 60 dogs that were euthanased because of thoracolumbar IVD herniation. Clinical neurological grades correlated significantly with the extent of white matter damage (P<0.001). However, loss of nociception also occurred in 6/31 (19%) dogs with relatively mild histological changes. The duration of clinical signs, Schiff-Sherrington posture, loss of reflexes and pain on spinal palpation were not significantly associated with the severity of spinal cord damage. Although clinical-pathological correlation was generally good, some clinical signs frequently thought to indicate severe cord injury did not always correlate with the degree of cord damage, suggesting functional rather than structural impairment in some cases.

Authors+Show Affiliations

Department of Clinical Veterinary Medicine, Division of Clinical Neurology, Vetsuisse Faculty, University of Bern, Bern 3001, Switzerland. Electronic address: diana.henke@vetsuisse.unibe.ch.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23702280

Citation

Henke, D, et al. "Correlations Between Severity of Clinical Signs and Histopathological Changes in 60 Dogs With Spinal Cord Injury Associated With Acute Thoracolumbar Intervertebral Disc Disease." Veterinary Journal (London, England : 1997), vol. 198, no. 1, 2013, pp. 70-5.
Henke D, Vandevelde M, Doherr MG, et al. Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. Vet J. 2013;198(1):70-5.
Henke, D., Vandevelde, M., Doherr, M. G., Stöckli, M., & Forterre, F. (2013). Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. Veterinary Journal (London, England : 1997), 198(1), 70-5. https://doi.org/10.1016/j.tvjl.2013.04.003
Henke D, et al. Correlations Between Severity of Clinical Signs and Histopathological Changes in 60 Dogs With Spinal Cord Injury Associated With Acute Thoracolumbar Intervertebral Disc Disease. Vet J. 2013;198(1):70-5. PubMed PMID: 23702280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. AU - Henke,D, AU - Vandevelde,M, AU - Doherr,M G, AU - Stöckli,M, AU - Forterre,F, Y1 - 2013/05/20/ PY - 2012/02/05/received PY - 2013/04/03/revised PY - 2013/04/07/accepted PY - 2013/5/25/entrez PY - 2013/5/25/pubmed PY - 2014/6/20/medline KW - Canine KW - Intervertebral disc extrusion KW - Schiff-Sherrington posture SP - 70 EP - 5 JF - Veterinary journal (London, England : 1997) JO - Vet. J. VL - 198 IS - 1 N2 - The outcome of spinal surgery in dogs with absent voluntary motor function and nociception following intervertebral disc (IVD) herniation is highly variable, which likely attests to differences in the severity of spinal cord damage. This retrospective study evaluated the extent to which neurological signs correlated with histologically detected spinal cord damage in 60 dogs that were euthanased because of thoracolumbar IVD herniation. Clinical neurological grades correlated significantly with the extent of white matter damage (P<0.001). However, loss of nociception also occurred in 6/31 (19%) dogs with relatively mild histological changes. The duration of clinical signs, Schiff-Sherrington posture, loss of reflexes and pain on spinal palpation were not significantly associated with the severity of spinal cord damage. Although clinical-pathological correlation was generally good, some clinical signs frequently thought to indicate severe cord injury did not always correlate with the degree of cord damage, suggesting functional rather than structural impairment in some cases. SN - 1532-2971 UR - https://www.unboundmedicine.com/medline/citation/23702280/Correlations_between_severity_of_clinical_signs_and_histopathological_changes_in_60_dogs_with_spinal_cord_injury_associated_with_acute_thoracolumbar_intervertebral_disc_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-0233(13)00174-3 DB - PRIME DP - Unbound Medicine ER -