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8-isoprostane levels in serum and bronchoalveolar lavage in idiopathic pulmonary fibrosis and sarcoidosis.
Food Chem Toxicol. 2013 Nov; 61:160-3.FC

Abstract

OBJECTIVE AND DESIGN

Sarcoidosis and idiopathic pulmonary fibrosis (IPF) are both associated with deregulated inflammatory mechanisms partially triggered by aggravated oxidative stress. 8-Isoprostane has been proposed as a reliable marker of oxidative stress, linked to several pulmonary diseases. We aimed to explore differences in 8-isoprostane levels in IPF and sarcoidosis patients, and controls.

METHODS

We included 16 IPF and 55 sarcoidosis patients, as well as 17 controls in the study. 8-Isoprostane levels were measured in serum and in bronchoalveolar lavage (BAL).

RESULTS

Serum 8-isoprostane levels were increased in all patient groups vs controls (p<0.001). The systemic 8-isoprostane concentrations were higher in sarcoidosis patients as compared to IPF subjects and controls (p=0.017 and p<0.001, respectively). IPF patients exhibited increased serum 8-isoprostane levels when compared to controls (p<0.001). Sarcoidosis patients presented significantly increased 8-isoprostane BAL levels when compared to IPF patients (p=0.002).

CONCLUSION

Our data indicate that the level of oxidative stress, as reflected by 8-isoprostane concentrations, is enhanced in patients with sarcoidosis, and to a lesser extent, in IPF patients when compared to controls, suggesting a potential implication of redox imbalance in both diseases.

Authors+Show Affiliations

Respiratory Medicine Department, School of Medicine, University of Thessaly, Larissa, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23702326

Citation

Malli, Foteini, et al. "8-isoprostane Levels in Serum and Bronchoalveolar Lavage in Idiopathic Pulmonary Fibrosis and Sarcoidosis." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 61, 2013, pp. 160-3.
Malli F, Bardaka F, Tsilioni I, et al. 8-isoprostane levels in serum and bronchoalveolar lavage in idiopathic pulmonary fibrosis and sarcoidosis. Food Chem Toxicol. 2013;61:160-3.
Malli, F., Bardaka, F., Tsilioni, I., Karetsi, E., Gourgoulianis, K. I., & Daniil, Z. (2013). 8-isoprostane levels in serum and bronchoalveolar lavage in idiopathic pulmonary fibrosis and sarcoidosis. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 61, 160-3. https://doi.org/10.1016/j.fct.2013.05.016
Malli F, et al. 8-isoprostane Levels in Serum and Bronchoalveolar Lavage in Idiopathic Pulmonary Fibrosis and Sarcoidosis. Food Chem Toxicol. 2013;61:160-3. PubMed PMID: 23702326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 8-isoprostane levels in serum and bronchoalveolar lavage in idiopathic pulmonary fibrosis and sarcoidosis. AU - Malli,Foteini, AU - Bardaka,Fotini, AU - Tsilioni,Irene, AU - Karetsi,Eleni, AU - Gourgoulianis,Konstantinos I, AU - Daniil,Zoe, Y1 - 2013/05/20/ PY - 2013/01/25/received PY - 2013/04/15/revised PY - 2013/05/09/accepted PY - 2013/5/25/entrez PY - 2013/5/25/pubmed PY - 2014/10/7/medline KW - BAL KW - DPLDs KW - EBC KW - IPF KW - Idiopathic pulmonary fibrosis KW - Isoprostane KW - Oxidative stress KW - PFTs KW - ROS KW - Sarcoidosis KW - bronchoalveolar lavage KW - diffuse parenchymal lung diseases KW - exhaled breath condensate KW - idiopathic pulmonary fibrosis KW - pulmonary function testing KW - reactive oxygen species SP - 160 EP - 3 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 61 N2 - OBJECTIVE AND DESIGN: Sarcoidosis and idiopathic pulmonary fibrosis (IPF) are both associated with deregulated inflammatory mechanisms partially triggered by aggravated oxidative stress. 8-Isoprostane has been proposed as a reliable marker of oxidative stress, linked to several pulmonary diseases. We aimed to explore differences in 8-isoprostane levels in IPF and sarcoidosis patients, and controls. METHODS: We included 16 IPF and 55 sarcoidosis patients, as well as 17 controls in the study. 8-Isoprostane levels were measured in serum and in bronchoalveolar lavage (BAL). RESULTS: Serum 8-isoprostane levels were increased in all patient groups vs controls (p<0.001). The systemic 8-isoprostane concentrations were higher in sarcoidosis patients as compared to IPF subjects and controls (p=0.017 and p<0.001, respectively). IPF patients exhibited increased serum 8-isoprostane levels when compared to controls (p<0.001). Sarcoidosis patients presented significantly increased 8-isoprostane BAL levels when compared to IPF patients (p=0.002). CONCLUSION: Our data indicate that the level of oxidative stress, as reflected by 8-isoprostane concentrations, is enhanced in patients with sarcoidosis, and to a lesser extent, in IPF patients when compared to controls, suggesting a potential implication of redox imbalance in both diseases. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23702326/8_isoprostane_levels_in_serum_and_bronchoalveolar_lavage_in_idiopathic_pulmonary_fibrosis_and_sarcoidosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(13)00320-7 DB - PRIME DP - Unbound Medicine ER -