Tags

Type your tag names separated by a space and hit enter

The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease.
Alzheimers Dement 2014; 10(3):401-4AD

Abstract

BACKGROUND

In this multicenter study, we investigated a possible association between the APOE ε4 allele and white matter (WM) integrity in Alzheimer's disease (AD) using diffusion tensor imaging (DTI).

METHODS

We analyzed fractional anisotropy (FA) and mean diffusivity (MD) as indices of WM integrity in 70 AD patients (35 APOE ε4 carriers, 35 noncarriers) and 56 healthy control (HC) subjects (28 APOE ε4 carriers, 28 noncarriers). APOE ε4 carriers and noncarriers were matched for age and gender within each diagnostic group.

RESULTS

We found significant effects of diagnosis (Pcorrected < .05 [FWE]; i.e., smaller FA values and larger MD values in AD patients compared with HCs) and significant effects (P < .001) of APOE ε4 carrier status on MD in HCs but not in AD subjects.

CONCLUSIONS

The results indicate that APOE ε4 has a moderate effect on WM integrity in HCs, but no effect on WM integrity in manifest AD.

Authors+Show Affiliations

DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany. Electronic address: vanja.kljajevic@gmail.com.Institute of Medical Genetics, University Medicine, Rostock, Germany.Institute of Medical Genetics, University Medicine, Rostock, Germany.DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany; Mobile Multimedia Information Systems Group, University of Rostock, Rostock, Germany.DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany.Cognitive Systems Group, Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.Department of Psychiatry, University Medical Center of Mainz, Mainz, Germany.Department of Magnetic Resonance Imaging, Institute for Clinical Radiology, Ludwig Maximilian University Munich, Munich, Germany.Department of Psychiatry, University of Frankfurt, Frankfurt, Germany.DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany; Department of Psychiatry, University of Rostock, Rostock, Germany.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

23706516

Citation

Kljajevic, Vanja, et al. "The Ε4 Genotype of Apolipoprotein E and White Matter Integrity in Alzheimer's Disease." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 10, no. 3, 2014, pp. 401-4.
Kljajevic V, Meyer P, Holzmann C, et al. The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease. Alzheimers Dement. 2014;10(3):401-4.
Kljajevic, V., Meyer, P., Holzmann, C., Dyrba, M., Kasper, E., Bokde, A. L., ... Teipel, S. (2014). The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 10(3), pp. 401-4. doi:10.1016/j.jalz.2013.02.008.
Kljajevic V, et al. The Ε4 Genotype of Apolipoprotein E and White Matter Integrity in Alzheimer's Disease. Alzheimers Dement. 2014;10(3):401-4. PubMed PMID: 23706516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease. AU - Kljajevic,Vanja, AU - Meyer,Peter, AU - Holzmann,Carsten, AU - Dyrba,Martin, AU - Kasper,Elisabeth, AU - Bokde,Arun L W, AU - Fellgiebel,Andreas, AU - Meindl,Thomas, AU - Hampel,Harald, AU - Teipel,Stefan, AU - ,, Y1 - 2013/05/21/ PY - 2012/07/11/received PY - 2013/02/01/revised PY - 2013/02/07/accepted PY - 2013/5/28/entrez PY - 2013/5/28/pubmed PY - 2014/12/15/medline KW - APOE ε4 KW - Alzheimer's disease KW - Diffusion tensor imaging KW - White matter SP - 401 EP - 4 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 10 IS - 3 N2 - BACKGROUND: In this multicenter study, we investigated a possible association between the APOE ε4 allele and white matter (WM) integrity in Alzheimer's disease (AD) using diffusion tensor imaging (DTI). METHODS: We analyzed fractional anisotropy (FA) and mean diffusivity (MD) as indices of WM integrity in 70 AD patients (35 APOE ε4 carriers, 35 noncarriers) and 56 healthy control (HC) subjects (28 APOE ε4 carriers, 28 noncarriers). APOE ε4 carriers and noncarriers were matched for age and gender within each diagnostic group. RESULTS: We found significant effects of diagnosis (Pcorrected < .05 [FWE]; i.e., smaller FA values and larger MD values in AD patients compared with HCs) and significant effects (P < .001) of APOE ε4 carrier status on MD in HCs but not in AD subjects. CONCLUSIONS: The results indicate that APOE ε4 has a moderate effect on WM integrity in HCs, but no effect on WM integrity in manifest AD. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/23706516/The_ε4_genotype_of_apolipoprotein_E_and_white_matter_integrity_in_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(13)00084-8 DB - PRIME DP - Unbound Medicine ER -