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Clinical significance of homocysteine (hcy) on dementia in Parkinson's disease (PD).
Arch Gerontol Geriatr. 2013 Nov-Dec; 57(3):288-91.AG

Abstract

Cognitive dysfunction and dementia are common non-motor symptoms of PD. hcy has various neuronal and endothelial cellular toxicities. The clinical relevance of the levodopa associated with elevated hcy level and its effect on the course of cognitive decline in PD are still undetermined. We conducted this study to clarify the clinical significance of elevated hcy in PD associated with dementia in the Korean population. A total of 33 PD patients without dementia (PDwoD) and 28 PD patients with dementia (PDD) who were recruited for this study were compared with 48 HCs to confirm the value of hcy as a contributing factor of dementia associated with PD. PD patients had neuropsychological tests and neurological examinations performed. The plasma hcy level was measured routinely in all patients and HCs. The hcy of PDD showed a higher hcy level than those of PDwoD as well as HCs. In considering each group of PDwoD and PDD, there were no intercorrelations between hcy levels, duration of PD symptoms, duration of PD treatment, or the results of neuropsychological tests. In conclusion, we ascertained that hcy level was related to the cognitive decline of PD patients. However we were unable to confirm a clear pathophysiologic role of hcy in PDD and the relationship between hcy and levodopa, significantly.

Authors+Show Affiliations

Department of Neurology, Incheon St. Mary's Hospital, The Catholic University of Korea, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23706974

Citation

Song, In-Uk, et al. "Clinical Significance of Homocysteine (hcy) On Dementia in Parkinson's Disease (PD)." Archives of Gerontology and Geriatrics, vol. 57, no. 3, 2013, pp. 288-91.
Song IU, Kim JS, Park IS, et al. Clinical significance of homocysteine (hcy) on dementia in Parkinson's disease (PD). Arch Gerontol Geriatr. 2013;57(3):288-91.
Song, I. U., Kim, J. S., Park, I. S., Kim, Y. D., Cho, H. J., Chung, S. W., & Lee, K. S. (2013). Clinical significance of homocysteine (hcy) on dementia in Parkinson's disease (PD). Archives of Gerontology and Geriatrics, 57(3), 288-91. https://doi.org/10.1016/j.archger.2013.04.015
Song IU, et al. Clinical Significance of Homocysteine (hcy) On Dementia in Parkinson's Disease (PD). Arch Gerontol Geriatr. 2013 Nov-Dec;57(3):288-91. PubMed PMID: 23706974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical significance of homocysteine (hcy) on dementia in Parkinson's disease (PD). AU - Song,In-Uk, AU - Kim,Joong-Seok, AU - Park,In-Seok, AU - Kim,Young-Do, AU - Cho,Hyun-Ji, AU - Chung,Sung-Woo, AU - Lee,Kwang-Soo, Y1 - 2013/05/23/ PY - 2012/06/04/received PY - 2013/04/26/revised PY - 2013/04/27/accepted PY - 2013/5/28/entrez PY - 2013/5/28/pubmed PY - 2014/4/4/medline KW - Dementia KW - Levodopa KW - PD KW - hcy SP - 288 EP - 91 JF - Archives of gerontology and geriatrics JO - Arch Gerontol Geriatr VL - 57 IS - 3 N2 - Cognitive dysfunction and dementia are common non-motor symptoms of PD. hcy has various neuronal and endothelial cellular toxicities. The clinical relevance of the levodopa associated with elevated hcy level and its effect on the course of cognitive decline in PD are still undetermined. We conducted this study to clarify the clinical significance of elevated hcy in PD associated with dementia in the Korean population. A total of 33 PD patients without dementia (PDwoD) and 28 PD patients with dementia (PDD) who were recruited for this study were compared with 48 HCs to confirm the value of hcy as a contributing factor of dementia associated with PD. PD patients had neuropsychological tests and neurological examinations performed. The plasma hcy level was measured routinely in all patients and HCs. The hcy of PDD showed a higher hcy level than those of PDwoD as well as HCs. In considering each group of PDwoD and PDD, there were no intercorrelations between hcy levels, duration of PD symptoms, duration of PD treatment, or the results of neuropsychological tests. In conclusion, we ascertained that hcy level was related to the cognitive decline of PD patients. However we were unable to confirm a clear pathophysiologic role of hcy in PDD and the relationship between hcy and levodopa, significantly. SN - 1872-6976 UR - https://www.unboundmedicine.com/medline/citation/23706974/Clinical_significance_of_homocysteine__hcy__on_dementia_in_Parkinson's_disease__PD__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-4943(13)00075-7 DB - PRIME DP - Unbound Medicine ER -