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Dual time point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: nodal staging in locally advanced breast cancer.
Rev Esp Med Nucl Imagen Mol. 2014 Jan-Feb; 33(1):1-5.RE

Abstract

AIM

To assess dual time point 2-deoxy-2-[(18)F]fluoro-D-glucose (18)(F)FDG PET-CT accuracy in nodal staging and in detection of extra-axillary involvement.

MATERIAL AND METHODS

Dual time point [(18)F] FDG PET/CT scan was performed in 75 patients. Visual and semiquantitative assessment of lymph nodes was performed. Semiquantitative measurement of SUV and ROC-analysis were carried out to calculate SUV(max) cut-off value with the best diagnostic performance. Axillary and extra-axillary lymph node chains were evaluated.

RESULTS

Sensitivity and specificity of visual assessment was 87.3% and 75%, respectively. SUV(max) values with the best sensitivity were 0.90 and 0.95 for early and delayed PET, respectively. SUV(max) values with the best specificity were 1.95 and 2.75, respectively. Extra-axillary lymph node involvement was detected in 26.7%.

CONCLUSION

FDG PET/CT detected extra-axillary lymph node involvement in one-fourth of the patients. Semiquantitative lymph node analysis did not show any advantage over the visual evaluation.

Authors+Show Affiliations

Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain. Electronic address: angarvice@yahoo.es.Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain.Oncology Department, Virgen de la Salud Hospital, Toledo, Spain.Oncology Department, Virgen de la Luz Hospital, Cuenca, Spain.Oncology Department, La Mancha Centro Hospital, Alcázar de San Juan, Ciudad Real, Spain.Investigation Unit, University General Hospital, Ciudad Real, Spain.Oncology Department, Nuestra Sra. del Prado Hospital, Talavera de la Reina, Toledo, Spain.Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain.

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

23707190

Citation

García Vicente, A M., et al. "Dual Time Point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: Nodal Staging in Locally Advanced Breast Cancer." Revista Espanola De Medicina Nuclear E Imagen Molecular, vol. 33, no. 1, 2014, pp. 1-5.
García Vicente AM, Soriano Castrejón A, Cruz Mora MÁ, et al. Dual time point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: nodal staging in locally advanced breast cancer. Rev Esp Med Nucl Imagen Mol. 2014;33(1):1-5.
García Vicente, A. M., Soriano Castrejón, A., Cruz Mora, M. Á., Ortega Ruiperez, C., Espinosa Aunión, R., León Martín, A., González Ageitos, A., & Van Gómez López, O. (2014). Dual time point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: nodal staging in locally advanced breast cancer. Revista Espanola De Medicina Nuclear E Imagen Molecular, 33(1), 1-5. https://doi.org/10.1016/j.remn.2013.03.005
García Vicente AM, et al. Dual Time Point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: Nodal Staging in Locally Advanced Breast Cancer. Rev Esp Med Nucl Imagen Mol. 2014 Jan-Feb;33(1):1-5. PubMed PMID: 23707190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dual time point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: nodal staging in locally advanced breast cancer. AU - García Vicente,A M, AU - Soriano Castrejón,A, AU - Cruz Mora,M Á, AU - Ortega Ruiperez,C, AU - Espinosa Aunión,R, AU - León Martín,A, AU - González Ageitos,A, AU - Van Gómez López,O, Y1 - 2013/05/23/ PY - 2013/02/12/received PY - 2013/03/21/revised PY - 2013/03/22/accepted PY - 2013/5/28/entrez PY - 2013/5/28/pubmed PY - 2015/4/14/medline KW - (18)(F)FDG PET/CT KW - Cáncer de mama localmente avanzado KW - Dual time point PET KW - Estadificación ganglionar KW - Locally advanced breast cancer KW - Lymph node staging KW - PET en doble fase KW - [(18)F] FDG PET-TC SP - 1 EP - 5 JF - Revista espanola de medicina nuclear e imagen molecular JO - Rev Esp Med Nucl Imagen Mol VL - 33 IS - 1 N2 - AIM: To assess dual time point 2-deoxy-2-[(18)F]fluoro-D-glucose (18)(F)FDG PET-CT accuracy in nodal staging and in detection of extra-axillary involvement. MATERIAL AND METHODS: Dual time point [(18)F] FDG PET/CT scan was performed in 75 patients. Visual and semiquantitative assessment of lymph nodes was performed. Semiquantitative measurement of SUV and ROC-analysis were carried out to calculate SUV(max) cut-off value with the best diagnostic performance. Axillary and extra-axillary lymph node chains were evaluated. RESULTS: Sensitivity and specificity of visual assessment was 87.3% and 75%, respectively. SUV(max) values with the best sensitivity were 0.90 and 0.95 for early and delayed PET, respectively. SUV(max) values with the best specificity were 1.95 and 2.75, respectively. Extra-axillary lymph node involvement was detected in 26.7%. CONCLUSION: FDG PET/CT detected extra-axillary lymph node involvement in one-fourth of the patients. Semiquantitative lymph node analysis did not show any advantage over the visual evaluation. SN - 2253-8070 UR - https://www.unboundmedicine.com/medline/citation/23707190/Dual_time_point_2_deoxy_2_[18F]fluoro_D_glucose_PET/CT:_nodal_staging_in_locally_advanced_breast_cancer_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S2253-654X(13)00044-9 DB - PRIME DP - Unbound Medicine ER -