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A metaanalysis on alcohol consumption and risk of endometriosis.
Am J Obstet Gynecol. 2013 Aug; 209(2):106.e1-10.AJ

Abstract

OBJECTIVE

To offer a general figure of the available data on the relation between alcohol intake and risk of endometriosis, we conducted a systematic review and a metaanalysis of studies published up to May 2012.

STUDY DESIGN

We carried out a literature search of all case-control and cohort studies published as original articles in English up to May 2012. Only those papers that were published as full-length articles were considered. Pooled estimates of the relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were calculated using fixed or, when significant heterogeneity among estimates emerged, random effects models. A total of 15 studies were identified for the review.

RESULTS

The summary estimate was 1.24 (95% CI, 1.12-1.36) for any alcohol intake vs no alcohol intake. Considering the results of the analyses of infrequent, moderate/regular, and heavy alcohol intake vs no alcohol intake, the summary RR estimates were, respectively, 1.14 (95% CI, 0.86-1.52), 1.23 (95% CI, 1.08-1.40), and 1.19 (95% CI, 0.99-1.43). Three studies reported separate results for current and former drinkers, and the summary RR were 1.42 (95% CI, 1.14-1.76) and 1.09 (95% CI, 0.83-1.43), respectively.

CONCLUSION

The present metaanalysis provides evidence for an association between alcohol consumption and endometriosis risk. Further studies are needed to clarify whether alcohol consumption may exacerbate an existing disease or could be related to the severity of the disease.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Parazzini F
Department of Obstetrics, Gynecology, and Neonatology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. fabio.parazzini@marionegri.it
Cipriani S
No affiliation info available
Bravi F
No affiliation info available
Pelucchi C
No affiliation info available
Chiaffarino F
No affiliation info available
Ricci E
No affiliation info available
Viganò P
No affiliation info available

MeSH

Alcohol DrinkingCase-Control StudiesCohort StudiesEndometriosisFemaleHumansRisk Factors

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

23707678

Citation

Parazzini, Fabio, et al. "A Metaanalysis On Alcohol Consumption and Risk of Endometriosis." American Journal of Obstetrics and Gynecology, vol. 209, no. 2, 2013, pp. 106.e1-10.
Parazzini F, Cipriani S, Bravi F, et al. A metaanalysis on alcohol consumption and risk of endometriosis. Am J Obstet Gynecol. 2013;209(2):106.e1-10.
Parazzini, F., Cipriani, S., Bravi, F., Pelucchi, C., Chiaffarino, F., Ricci, E., & Viganò, P. (2013). A metaanalysis on alcohol consumption and risk of endometriosis. American Journal of Obstetrics and Gynecology, 209(2), e1-10. https://doi.org/10.1016/j.ajog.2013.05.039
Parazzini F, et al. A Metaanalysis On Alcohol Consumption and Risk of Endometriosis. Am J Obstet Gynecol. 2013;209(2):106.e1-10. PubMed PMID: 23707678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A metaanalysis on alcohol consumption and risk of endometriosis. AU - Parazzini,Fabio, AU - Cipriani,Sonia, AU - Bravi,Francesca, AU - Pelucchi,Claudio, AU - Chiaffarino,Francesca, AU - Ricci,Elena, AU - Viganò,Paola, Y1 - 2013/05/23/ PY - 2013/01/31/received PY - 2013/04/15/revised PY - 2013/05/22/accepted PY - 2013/5/28/entrez PY - 2013/5/28/pubmed PY - 2013/9/28/medline KW - alcohol KW - endometriosis KW - epidemiology KW - risk factor SP - 106.e1 EP - 10 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 209 IS - 2 N2 - OBJECTIVE: To offer a general figure of the available data on the relation between alcohol intake and risk of endometriosis, we conducted a systematic review and a metaanalysis of studies published up to May 2012. STUDY DESIGN: We carried out a literature search of all case-control and cohort studies published as original articles in English up to May 2012. Only those papers that were published as full-length articles were considered. Pooled estimates of the relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were calculated using fixed or, when significant heterogeneity among estimates emerged, random effects models. A total of 15 studies were identified for the review. RESULTS: The summary estimate was 1.24 (95% CI, 1.12-1.36) for any alcohol intake vs no alcohol intake. Considering the results of the analyses of infrequent, moderate/regular, and heavy alcohol intake vs no alcohol intake, the summary RR estimates were, respectively, 1.14 (95% CI, 0.86-1.52), 1.23 (95% CI, 1.08-1.40), and 1.19 (95% CI, 0.99-1.43). Three studies reported separate results for current and former drinkers, and the summary RR were 1.42 (95% CI, 1.14-1.76) and 1.09 (95% CI, 0.83-1.43), respectively. CONCLUSION: The present metaanalysis provides evidence for an association between alcohol consumption and endometriosis risk. Further studies are needed to clarify whether alcohol consumption may exacerbate an existing disease or could be related to the severity of the disease. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/23707678/full_citation DB - PRIME DP - Unbound Medicine ER -