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Clinical validity of tissue carcinoembryonic antigen expression as ancillary to serum carcinoembryonic antigen concentration in patients curatively resected for colorectal cancer.
Colorectal Dis. 2013 Sep; 15(9):e503-11.CD

Abstract

AIM

Although serum carcinoembryonic antigen (CEA) level is prognostic in colorectal cancer, the prognostic role of tumour CEA expression is unclear. The aim of this study is to identify the prognostic and surveillance roles of tissue CEA expression along with serum CEA concentration in patients curatively resected for colorectal cancer.

METHOD

Between January and December 2003, 294 patients who underwent curative resection for colorectal cancer were included in the study. Correlation of tissue CEA expression with overall survival (OS), disease-free survival (DFS) and elevated serum CEA concentration at tumour recurrence were analysed.

RESULTS

Tissue CEA expression was positive in 215 patients (73.1%). CEA expression was an independent prognostic factor for OS [hazard ratio (HR) = 2.537, 95% confidence interval (CI) = 1.065-6.042, P = 0.035] and DFS (HR = 3.090, 95% CI = 1.405-6.795, P = 0.005). Elevation of serum CEA at tumour recurrence was significantly lower in patients without than with tissue CEA expression (14.3 vs 57.6%, P = 0.045). Moreover, when patients were grouped according to a combination of serum CEA elevation and tissue CEA expression, those with tissue CEA expression and elevated serum CEA (group 3) had significantly poorer OS and DFS (P < 0.001 each) than those without CEA expression and elevated serum CEA (group 1) and those with either tissue CEA expression or elevated serum CEA (group 2). OS (P = 0.006) and DFS (P = 0.027) were both significantly greater in group 1 than in group 2.

CONCLUSION

Tissue CEA expression is a prognostic factor in patients with colorectal cancer. Analysis of tissue CEA expression may be helpful in determining the clinical utility of serial measurements of serum CEA as surveillance in patients with curatively resected colorectal cancer.

Authors+Show Affiliations

Center for Colorectal Cancer, National Cancer Center, Goyang, Korea; Colorectal Cancer Branch, Research Institute, National Cancer Center, Goyang, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23711333

Citation

Park, J W., et al. "Clinical Validity of Tissue Carcinoembryonic Antigen Expression as Ancillary to Serum Carcinoembryonic Antigen Concentration in Patients Curatively Resected for Colorectal Cancer." Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, vol. 15, no. 9, 2013, pp. e503-11.
Park JW, Chang HJ, Kim BC, et al. Clinical validity of tissue carcinoembryonic antigen expression as ancillary to serum carcinoembryonic antigen concentration in patients curatively resected for colorectal cancer. Colorectal Dis. 2013;15(9):e503-11.
Park, J. W., Chang, H. J., Kim, B. C., Yeo, H. Y., & Kim, D. Y. (2013). Clinical validity of tissue carcinoembryonic antigen expression as ancillary to serum carcinoembryonic antigen concentration in patients curatively resected for colorectal cancer. Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, 15(9), e503-11. https://doi.org/10.1111/codi.12304
Park JW, et al. Clinical Validity of Tissue Carcinoembryonic Antigen Expression as Ancillary to Serum Carcinoembryonic Antigen Concentration in Patients Curatively Resected for Colorectal Cancer. Colorectal Dis. 2013;15(9):e503-11. PubMed PMID: 23711333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical validity of tissue carcinoembryonic antigen expression as ancillary to serum carcinoembryonic antigen concentration in patients curatively resected for colorectal cancer. AU - Park,J W, AU - Chang,H J, AU - Kim,B C, AU - Yeo,H Y, AU - Kim,D Y, PY - 2012/11/09/received PY - 2013/01/13/accepted PY - 2013/5/29/entrez PY - 2013/5/29/pubmed PY - 2014/5/16/medline KW - Colorectal neoplasm KW - carcinoembryonic antigen KW - immunohistochemistry KW - prognosis KW - surveillance SP - e503 EP - 11 JF - Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland JO - Colorectal Dis VL - 15 IS - 9 N2 - AIM: Although serum carcinoembryonic antigen (CEA) level is prognostic in colorectal cancer, the prognostic role of tumour CEA expression is unclear. The aim of this study is to identify the prognostic and surveillance roles of tissue CEA expression along with serum CEA concentration in patients curatively resected for colorectal cancer. METHOD: Between January and December 2003, 294 patients who underwent curative resection for colorectal cancer were included in the study. Correlation of tissue CEA expression with overall survival (OS), disease-free survival (DFS) and elevated serum CEA concentration at tumour recurrence were analysed. RESULTS: Tissue CEA expression was positive in 215 patients (73.1%). CEA expression was an independent prognostic factor for OS [hazard ratio (HR) = 2.537, 95% confidence interval (CI) = 1.065-6.042, P = 0.035] and DFS (HR = 3.090, 95% CI = 1.405-6.795, P = 0.005). Elevation of serum CEA at tumour recurrence was significantly lower in patients without than with tissue CEA expression (14.3 vs 57.6%, P = 0.045). Moreover, when patients were grouped according to a combination of serum CEA elevation and tissue CEA expression, those with tissue CEA expression and elevated serum CEA (group 3) had significantly poorer OS and DFS (P < 0.001 each) than those without CEA expression and elevated serum CEA (group 1) and those with either tissue CEA expression or elevated serum CEA (group 2). OS (P = 0.006) and DFS (P = 0.027) were both significantly greater in group 1 than in group 2. CONCLUSION: Tissue CEA expression is a prognostic factor in patients with colorectal cancer. Analysis of tissue CEA expression may be helpful in determining the clinical utility of serial measurements of serum CEA as surveillance in patients with curatively resected colorectal cancer. SN - 1463-1318 UR - https://www.unboundmedicine.com/medline/citation/23711333/Clinical_validity_of_tissue_carcinoembryonic_antigen_expression_as_ancillary_to_serum_carcinoembryonic_antigen_concentration_in_patients_curatively_resected_for_colorectal_cancer_ L2 - https://doi.org/10.1111/codi.12304 DB - PRIME DP - Unbound Medicine ER -