Tags

Type your tag names separated by a space and hit enter

Benefit of a low-fat over high-fat diet on vascular health during alternate day fasting.
Nutr Diabetes. 2013 May 27; 3:e71.ND

Abstract

BACKGROUND

Alternate day fasting (ADF) with a low-fat (LF) diet improves brachial artery flow-mediated dilation (FMD). Whether these beneficial effects can be reproduced with a high-fat (HF) diet remains unclear.

OBJECTIVE

This study compared the effects of ADF-HF to ADF-LF regimens on FMD. The role that adipokines have in mediating this effect was also investigated.

METHODS

Thirty-two obese subjects were randomized to an ADF-HF (45% fat) or ADF-LF diet (25% fat), consisting of two phases: (1) a 2-week baseline weight maintenance period and (2) an 8-week ADF weight loss period. Food was provided throughout the study.

RESULTS

Body weight was reduced (P<0.0001) in the ADF-HF (4.4±1.0 kg) and ADF-LF group (3.7±0.7 kg). FMD decreased (P<0.05) by ADF-HF relative to baseline (7±1 to 5±2%) and increased (P<0.05) by ADF-LF (5±1 to 7±2%). Blood pressure remained unchanged in both groups. Adiponectin increased (P<0.05) in the ADF-HF (43±7%) and ADF-LF group (51±7%). Leptin and resistin decreased (P<0.05) in the ADF-HF (32±5%; 23±5%) and ADF-LF group (30±3%; 27±4%). Increases in adiponectin were associated with augmented FMD in the ADF-LF group only (r=0.34, P=0.03).

CONCLUSION

Thus, improvements in FMD with ADF may only occur with LF diets and not with HF diets, and adipokines may not have a significant role in mediating this effect.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23712283

Citation

Klempel, M C., et al. "Benefit of a Low-fat Over High-fat Diet On Vascular Health During Alternate Day Fasting." Nutrition & Diabetes, vol. 3, 2013, pp. e71.
Klempel MC, Kroeger CM, Norkeviciute E, et al. Benefit of a low-fat over high-fat diet on vascular health during alternate day fasting. Nutr Diabetes. 2013;3:e71.
Klempel, M. C., Kroeger, C. M., Norkeviciute, E., Goslawski, M., Phillips, S. A., & Varady, K. A. (2013). Benefit of a low-fat over high-fat diet on vascular health during alternate day fasting. Nutrition & Diabetes, 3, e71. https://doi.org/10.1038/nutd.2013.14
Klempel MC, et al. Benefit of a Low-fat Over High-fat Diet On Vascular Health During Alternate Day Fasting. Nutr Diabetes. 2013 May 27;3:e71. PubMed PMID: 23712283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benefit of a low-fat over high-fat diet on vascular health during alternate day fasting. AU - Klempel,M C, AU - Kroeger,C M, AU - Norkeviciute,E, AU - Goslawski,M, AU - Phillips,S A, AU - Varady,K A, Y1 - 2013/05/27/ PY - 2013/5/29/entrez PY - 2013/5/29/pubmed PY - 2013/5/29/medline SP - e71 EP - e71 JF - Nutrition & diabetes JO - Nutr Diabetes VL - 3 N2 - BACKGROUND: Alternate day fasting (ADF) with a low-fat (LF) diet improves brachial artery flow-mediated dilation (FMD). Whether these beneficial effects can be reproduced with a high-fat (HF) diet remains unclear. OBJECTIVE: This study compared the effects of ADF-HF to ADF-LF regimens on FMD. The role that adipokines have in mediating this effect was also investigated. METHODS: Thirty-two obese subjects were randomized to an ADF-HF (45% fat) or ADF-LF diet (25% fat), consisting of two phases: (1) a 2-week baseline weight maintenance period and (2) an 8-week ADF weight loss period. Food was provided throughout the study. RESULTS: Body weight was reduced (P<0.0001) in the ADF-HF (4.4±1.0 kg) and ADF-LF group (3.7±0.7 kg). FMD decreased (P<0.05) by ADF-HF relative to baseline (7±1 to 5±2%) and increased (P<0.05) by ADF-LF (5±1 to 7±2%). Blood pressure remained unchanged in both groups. Adiponectin increased (P<0.05) in the ADF-HF (43±7%) and ADF-LF group (51±7%). Leptin and resistin decreased (P<0.05) in the ADF-HF (32±5%; 23±5%) and ADF-LF group (30±3%; 27±4%). Increases in adiponectin were associated with augmented FMD in the ADF-LF group only (r=0.34, P=0.03). CONCLUSION: Thus, improvements in FMD with ADF may only occur with LF diets and not with HF diets, and adipokines may not have a significant role in mediating this effect. SN - 2044-4052 UR - https://www.unboundmedicine.com/medline/citation/23712283/Benefit_of_a_low_fat_over_high_fat_diet_on_vascular_health_during_alternate_day_fasting_ L2 - https://doi.org/10.1038/nutd.2013.14 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.