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New insights into atopic dermatitis: role of skin barrier and immune dysregulation.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is often associated with the development of food allergy and asthma. New insights into AD reveals an important role for structural abnormalities in the epidermis resulting in a leaky epithelial barrier as well as chronic immune activation that contribute to the pathophysiology of this common skin disease. Patients with AD have a predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus (HSV). Measures directed at healing and protecting the skin barrier and controlling the immune activation are needed for effective management of AD. Early intervention may improve outcomes for AD as well as reduce the systemic allergen sensitization that may lead to associated allergic diseases in other organs.

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  • Authors+Show Affiliations

    Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA. leungd@njhealth.org

    Source

    MeSH

    Child, Preschool
    Dermatitis, Atopic
    Herpes Simplex
    Humans
    Infant
    Simplexvirus
    Skin Physiological Phenomena
    Staphylococcal Skin Infections
    Staphylococcus aureus

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23712284

    Citation

    Leung, Donald Y M.. "New Insights Into Atopic Dermatitis: Role of Skin Barrier and Immune Dysregulation." Allergology International : Official Journal of the Japanese Society of Allergology, vol. 62, no. 2, 2013, pp. 151-61.
    Leung DY. New insights into atopic dermatitis: role of skin barrier and immune dysregulation. Allergol Int. 2013;62(2):151-61.
    Leung, D. Y. (2013). New insights into atopic dermatitis: role of skin barrier and immune dysregulation. Allergology International : Official Journal of the Japanese Society of Allergology, 62(2), pp. 151-61. doi:10.2332/allergolint.13-RAI-0564.
    Leung DY. New Insights Into Atopic Dermatitis: Role of Skin Barrier and Immune Dysregulation. Allergol Int. 2013;62(2):151-61. PubMed PMID: 23712284.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - New insights into atopic dermatitis: role of skin barrier and immune dysregulation. A1 - Leung,Donald Y M, PY - 2013/03/27/received PY - 2013/5/29/entrez PY - 2013/5/29/pubmed PY - 2013/10/18/medline SP - 151 EP - 61 JF - Allergology international : official journal of the Japanese Society of Allergology JO - Allergol Int VL - 62 IS - 2 N2 - Atopic dermatitis (AD) is a chronic inflammatory skin disease that is often associated with the development of food allergy and asthma. New insights into AD reveals an important role for structural abnormalities in the epidermis resulting in a leaky epithelial barrier as well as chronic immune activation that contribute to the pathophysiology of this common skin disease. Patients with AD have a predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus (HSV). Measures directed at healing and protecting the skin barrier and controlling the immune activation are needed for effective management of AD. Early intervention may improve outcomes for AD as well as reduce the systemic allergen sensitization that may lead to associated allergic diseases in other organs. SN - 1440-1592 UR - https://www.unboundmedicine.com/medline/citation/23712284/New_insights_into_atopic_dermatitis:_role_of_skin_barrier_and_immune_dysregulation_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S1323-8930(15)30123-4 DB - PRIME DP - Unbound Medicine ER -